GSE
Peripheral Neuropathy - (3) Support healthy nerves and aid nerve regeneration
PN TREATMENT:(3) Support nerves and aid peripheral nerve regeneration
Malabsorption Problems / Lack of good intestinal bacteria
Malabsorption would obviously lead to nutritional
deficiencies - Malabsorption may occur from a wide variety of
causes:
One
common cause of malabsorption is a lack of beneficial intestinal bacteria needed
to digest food - This can be corrected by taking a quality probiotic supplement
with at least 50 billion CFU and a variety of good bacterial strains for a couple
of months, whilst incorporating dietary probiotics (e.g. quality yogurt) and prebiotics
(food for the good bacteria, such as bananas, garlic, onions, legumes, raw honey)
into your ongoing daily regimen.
Probiotics - "Pro Life "
B Vitamins
B vitamins are required
for healthy nerve function. They may help those who develop
peripheral neuropathy, especially when unassociated with a particular disease, such
as diabetes. Generally, the B-vitamins help convert carbohydrates into energy.
B6, B12 and Folate (form of folic
acid (B9) in body) are cofactors for the methyl donor molecule SAMe.
Regenerates nerves and promotes remyelination of nerve fibers.
Since vitamins B6, B12 and folate are
cofactors for SAMe, their deficiency may cause neurological
and psychiatric disturbances , including depression, dementia, myelopathy
and peripheral neuropathy, and folate deficiency has, in fact, been linked to PN.
Sadun AA. Metabolic optic neuropathies. Semin Ophthalmol.
2002 Mar;17(1):29-32.
SAMe -And Other Methyl Donor Molecules
Folic acid Dosage -
the amount found effective in peripheral neuropathy is 10 mg - 2 to 3 times/day.
Parry, T.E., Folate Deficient Neuropathy. ACTA Hematologica,
1990;84:108.
See below for B6 and B12 dosages
B1 (as Benfotiamine)
- a naturally-occurring, more bio-available form of B1 than conventional
thiamine supplements
Benfotiamine's
superior ability to penetrate cell membranes increases its bioavailability over
conventional thiamine hydrochloride - its unique molecular open-ring structure enabling it to pass directly
through cell membranes into the cell; Study in International Journal of Clinical
Pharmacology Therapy found that the bioavailability of benfotiamine is
3.6 X greater than thiamine hydrochloride;
Benfotiamine
results in the sustained increase of Thiamine Pyrophosphate (TPP) - can produce beneficial effects on general nerve health, neuropathy, retinopathy,
nephropathy, polyneuropathy, peripheral neuropathy, and coronary health for both
diabetics and non-diabetics; German study found that benfotiamine can relieve
neuropathy pain within 3 weeks.
Benfotiamine contains sulfur
Avoid
alcohol - notorious for depleting body's B1 levels
Symptoms
of B1 deficiency - include:
• Loss of appetite
• "Pins and needles" sensations
• Feeling of numbness, especially in the legs
• Muscle tenderness, particularly in the calf
muscles
Daily
Dosage of Benfotiamine - 100 - 600mg w/food
Food sources
of B1/Thiamine
• Excellent sources
of B1 - include Asparagus, Crimini Mushrooms, Spinach, Tuna, Brussels
Sprouts, Flax seeds, Green Peas;
• Good food sources
of B1 - Romaine Lettuce, mustard greens, summer squash, Green Beans,
Sunflower seeds, Cabbage, Tomatoes, Turnip Greens, Broccoli, Kale, Cauliflower,
Black Beans, Oranges, Bell Peppers, Swiss Chard, Navy Beans, Collard Greens, Dried
Peas, Carrots, Pineapple, Lentils, Garlic, Lima Beans, Sesame Seeds, Pinto Beans,
Grapes, Cantaloupe, Kidney Beans
Vitamin B2
Vitamin B6 (Pyridoxine)
Daily
Dosage of B6 - 2-8mg Pyridixine HCl
Do
not take more than 200 mg of B6 - as higher daily doses can actually cause
symptoms of neuropathy.
Vitamin B12/Methylcobalamine (sublingual tablets)
Vitamin
B12 protects the sheathing surrounding nerve cells and may promote regeneration
and growth of nerve cells - a study in the Journal of
Neurological Science postulated that methylcobalamine could increase protein
synthesis and help regenerate nerves . Scientists state that ultra-high
doses of methylcobalamine have been proven in clinical studies to produce nerve
regeneration . Conversely, a B12 deficiency may result in nerve damage.
The
liver can store 3 - 5 years supply of Vitamin B12
Food
sources of B12 - red meat, poultry, eggs, dairy products,
fish
Daily
dose - 2000mcg Methycobalamine twice daily; typical doses range
from 1000 - 5000 mcg; Methylcobalamine is more bioavailable than commonly supplemented
cyanocobalamine;
Vitamin B12 (Cobalamin)
Omega-3
The myelin sheath is primarily composed
of fatty acids
Optimize your essential fat intake -
ensure a good supply of both animal and plant-based
Omega-3 fats for myelin sheath integrity (also
important for controlling extent of inflammatory reaction)
***HIGH
PRIORITY ***
- Take an
omega-3 supplement
Powerful "O3-fix" - incorporates:
- The Dr. Johanna
BUDWIG PROTOCOL".
Fresh flax seed oil, with inherent high
content of Omega-3 Alpha Linolenic acid , is
proportionally blended with cottage cheese to make the
omega-3 water soluble and more easily absorbed by the body's cells.
For MS build up to a daily dose of 4-6
Tbsp. of flax oil . To supercharge the therapy, also add 3 Tbsp.fresh-ground flax seeds and strip down and take the mid-day (10am-2pm)
sun for 30-60 mins each day.
- Omega-3 EPA /
DHA supplements: .
Eg.
Krill Oil : 2 - 500 mg /day (total 1000 mg)
Or: Wild Salmon Oil: Take
2 - 1000mg caps with each of 2 daily meals.
EFAs -The Fats of Life
Flax Seed
The "O3-Fix"
Progesterone
Progesterone has been shown in animal
studies to promote the formation of new myelin sheaths
(Human
Reproduction 2000 Jun;15 Suppl 1:1-13 ,
J Steroid Biochem Mol Biol 1999 Apr-Jun;69:97-107 ,
Mult Scler 1997 Apr;3:105-12 ).
Progesterone promotes regeneration
and myelination of axons (myelin forms around neural axons, allowing nerve impulses
to travel faster); influences growth, differentiation and increases expression of
myelin-specific proteins in oligodendrocytes, and potentiates the formation of new
myelin sheaths by Schwann cells in vivo; antioxidant effect in injured nervous system;
multiple effects on glial (Neuron support) cells;
Progesterone - induced "blocking
factor"directly blocks T-cell activation; reduces the expression of pro-inflammatory
genes and their protein products;
Progesterone
is an essential building block for the stress hormone
CORTISOL . Under stress,
most of the Progesterone produced is converted
into the corticosteroid hormones to deal with the emotional stress or fight or flight
situations;
Adrenal exhaustion from aging /poor nutrition reduces
adrenal Progesteroneproduction. Also reduces anti-inflammatory
CORTISONE .
Progesterone- Pregnancy Hormone
Estrogen Dominance
Sulfur
Sulfur
is a component of B1 (thiamine).
Important for nerve function;
Sulfur is a component
of antioxidants (E.g.
glutathione, N-acetylcysteine (NAC), alpha-lipoic
acid (ALA))
Vitamin C is dependent on
sulfur for absorption.
For protection against potentially nerve-damaging oxidation reactions;
Sulfur
is a component of enzymes - E.g.
Coenzyme-A;
Sulfur
bonds (S- S)
connect proteins in connective tissue and are the basis
for its flexibility -
important in PN affected by connective tissue inflammation or degeneration;
Sulfur has a role in
detoxification - as a heavy
metal detoxifier and especially in liver detoxification; free metal ions or other
toxins may be the root cause of oxidative damage to nerves in PN.
Sulfur
DMSO -
Carrier and Penetrant / Stop Pain & inflammation
MSM -organic Sulfur
L-ARGININE
L-Arginine has potent neuroprotective properties -and
may be a therapeutic tool in ALS and neuropathy
Lee J ,
Ryu H ,
Kowall NW .Motor neuronal protection by
L-arginine prolongs survival of mutant SOD1 (G93A) ALS mice.
Biochem Biophys Res Commun. 2009 Jul 10;384(4):524-9.
PubMed
Eat a wholesome/nourishing diet
Eat lots of organic fruit & vegetables,
organic eggs from pastured hens, and eat organic meats from grass-fed animals/birds -
a raw egg smoothie (E,g, with fruit, yogurt and a banana) is an amazing
pick-me-up for those who are ailing! Just personally ensure that the
eggs come from a wholesome environment, where the chickens spend their day on pasture
and eat organic grains. Alternatively, if you are still worried about the raw eggs,
buy pasteurized eggs (i.e. shells are sterilized), now available in many supermarkets
(E.g. Davidson's eggs)
NIR class 4 laser therapy
NIR Class 4 laser therapy is an effective healing frequency
therapy in the infrared range (~700-1000 nanometers)
obtainable at reasonable cost at clinics throughout the
world, incl. the U.S. Not only stops the pain, but
also affects a cure
• Reduces pain
• Reduces inflammation
• Enhances tissue healing
NIR Class 4 laser therapy
Lion's mane mushroom
(found this, might be worth researching)
Nerve regeneration
using Lion's Mane mushroom(Hericium erinaceus) - contains molecules
known as hericenones and erinacines, two compounds suspected to stimulate nerve
growth factor (NGF).
Other nutrients needed to maintain myelin sheath integrity
Uric acid;
Vitamin D
Essential fatty acids;