Antioxidants - Fighters against free radical damage
GSE
CoQ10 - Super Antioxidant
Supplementing with CoQ10
There is no RDA or DV for CoQ10
Since it is produced in the body, CoQ10 is not
considered essential. However, like
some other nutrients (e.g. taurine, carnitine and choline), it could be called
"conditionally essential" because its endogenous production may not be able to
keep up with the body's demand. In such situations supplemental CoQ10 is
indicated.
CoQ10 supplementation is beneficial for the over 40's
and those of any age with depleted CoQ10 levels
Both the production of CoQ10 and its conversion
to ubiquinol begin to decline more rapidly around our 40's and 50's ;
CoQ10 provides a
boost for those of any age with substantially lower CoQ10 levels.
Due to factors mentioned above in "Every cell makes CoQ10, but many
are deficient in it, Why?".
Ubiquinol is the best form of supplemental CoQ10
Ubquinol is the already converted, active form of
CoQ10. To obtain benefit from CoQ10 for production of cellular energy
and reduction of signs of aging, your body must first convert ubiquinone (the
educed storage form of CoQ10) to its active form ubiquinol. By the age of 40 the
body has become much less efficient at converting ubiquinone to ubiquinol, and
so it is better to directly supplement with ubiquinol.
Ubiquinol remains in your blood stream much
longer than ubiquinone
Ernster
L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone
function. Biochem Biophys Acta, 1995.
The bioavailability of ubiquinol has been
shown to be higher than that of ubiquinone in both animal and human studies
Miles MV et al, Bioequivalence of
coenzyme Q10 from over the counter supplements. Nutr Res 2002; Zaghloul A-a et
al. Bioavailability assessment of oral coenzyme Q10 formulations in dogs. Drug
develop Ind Pharm 2002.
In a recent trial with human subjects, the
superior bioavailability profile of ubiquinol was clearly demonstrated
Hosoe K
et al, Study on safety and bioavailability of ubiquinol (Kaneka QH™) after
single and 4-week multiple oral administration to healthy volunteers. Regul
Toxicol Pharmacol. 2007;47:19-28.
The plasma of a healthy human has more than 90%
of CoQ10 as ubiquinol
After a decade of research and development, "Kaneka Nutrients"recently
created the first stabilized, bio-identical supplemental form of Ubiquinol
(called Kaneka QH™).
Through a biological process that ferments natural CoQ10.
Ubiquinol achieves higher elevations of circulating CoQ10 in the bloodstream
with a much smaller dose than when using a ubiquinone CoQ10 supplement.
Daily Dose of Ubiquinol
More serious health conditions require greater
CoQ10 doses . Accumulating
research indicates that the higher the dosage the greater the benefit and that
the only limiting factor on the CoQ10 dosage is the cost, which is not cheap.
• Healthy person 20-30.
Shouldn't need to supplement CoQ10 at all, unless they are particularly active
or have a condition causing lowered CoQ10 levels - in which case, they can take
ubiquinone, since their body can convert it efficiently to ubiquinol;
• Healthy person 30-40.
50mg
• Healthy person in 40's and 50's
(To prevent heart attack). 100mg
• 60's and older / Tired / Taking a
statin drug.
100-200mg
• Very sick. Typically
200-300 mg split into 2 or 3 doses; Some examples of amounts used in studies: 390 mg dose used in breast
cancer study, 1200 mg dose in
Parkinsons disease;
The Kaneka Dosing
Study of Kaneka QH ™
The study measured
total CoQ10 concentration in human plasma for various dosage levels:Total plasma
COQ10 concentration results were as follows:
Placebo (n=19),
90mg/day (n=20), 150mg/day (n=20), 300mg/day (n=19)
Began around 0.5 μg/ml for all participants and increased in a dose
dependent manner;
Reached over 7 μg/ml at a dose of 300mg/day (~2.5 μg/ml at 90mg
dose and ~3.5μg/ml at 150 mg dose)
Reached a plateau after about 2 weeks intake for all
doses
Returned to base levels ~12 days after supplementation was stopped
Best taken with a meal containing fat
Works better when taken with a meal.
Even better if the meal contains
fat in which to dissolve the CoQ10, and so provide better absorption.
Safety
No adverse effects in studies.
Kaneka Q10 has been tested in dozens of
safety studies up to clinical doses of 3,000 mgs per day, showing no adverse
effects.
Boost your body's own CoQ10 production by supplementing with B6
100 mg Vitamin B6 / day
How is the status of CoQ10 assessed?
In humans, plasma or serum CoQ10 concentrations
will serve as a good indicator of status . The best way to assay CoQ10 by HPLC (high pressure liquid
chromatography) by UV or electrochemical detection.
- Plasma CoQ10 may not
always reflect tissue status. Localized
deficiencies of CoQ10 may exist such as in the skeletal muscle or myocardial
tissue whilst plasma concentrations may show "normal" values. If biopsy material
is available, tissue CoQ10 analysis can yield more useful information
Steele PE et al, Clinical laboratory
monitoring of coenzyme Q10 use in neurologic and muscular diseases. Am J Clin
Pathol. 2004;121 Suppl:S113-20.
How are the body's CoQ10 levels affected by CoQ10 supplementation?
Normal serum/plasma CoQ10 concentrations.
In healthy
people, usually range from 0.5 - 1.0 µg per mL. Total body CoQ10 is estimated at
1.5-2g.
After oral CoQ10 supplementation.
Plasma/serum
concentrations reach a maximum after ~6 hours. The time to deplete to
half-maximum concentration is ~34 hours. With the ingestion of high doses of
CoQ10, plasma CoQ10 levels have been found to plateau after a dose of 2400 mg a
day.
Shults CW et al, Pilot trial of high dosages of coenzyme Q10 in patients with
Parkinson's disease. Exp Neurol. 2004;
CoQ10 in Skin Care
Mix ubiquinol into cream/lotion at 0.5% concentration.
After first dissolving it in a small amount of oil for
a smooth texture to your finished product.
Refe rences
http://kenayag.com.pl/dok/Kan.pdf