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CoQ10 - Super Antioxidant

Supplementing with CoQ10

There is no RDA or DV for CoQ10

Since it is produced in the body, CoQ10 is not considered essential.     However, like some other nutrients (e.g. taurine, carnitine and choline), it could be called “conditionally essential” because its endogenous production may not be able to keep up with the body's demand. In such situations supplemental CoQ10 is indicated.

CoQ10 supplementation is beneficial for the over 40's and those of any age with depleted CoQ10 levels

Both the production of CoQ10 and its conversion to ubiquinol begin to decline more rapidly around our 40's and 50's;

CoQ10 provides a boost for those of any age with substantially lower CoQ10 levels.   Due to factors mentioned above in “Every cell makes CoQ10, but many are deficient in it, Why?”.

Ubiquinol is the best form of supplemental CoQ10

Ubquinol is the already converted, active form of CoQ10.    To obtain benefit from CoQ10 for production of cellular energy and reduction of signs of aging, your body must first convert ubiquinone (the educed storage form of CoQ10) to its active form ubiquinol. By the age of 40 the body has become much less efficient at converting ubiquinone to ubiquinol, and so it is better to directly supplement with ubiquinol.

Ubiquinol remains in your blood stream much longer than ubiquinone

Ernster L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochem Biophys Acta, 1995.

The bioavailability of ubiquinol has been shown to be higher than that of ubiquinone in both animal and human studies

Miles MV et al, Bioequivalence of coenzyme Q10 from over the counter supplements. Nutr Res 2002; Zaghloul A-a et al. Bioavailability assessment of oral coenzyme Q10 formulations in dogs. Drug develop Ind Pharm 2002.

In a recent trial with human subjects, the superior bioavailability profile of ubiquinol was clearly demonstrated

Hosoe K et al, Study on safety and bioavailability of ubiquinol (Kaneka QH™) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007;47:19-28.

The plasma of a healthy human has more than 90% of CoQ10 as ubiquinol

After a decade of research and development, “Kaneka Nutrients”recently created the first stabilized, bio-identical supplemental form of Ubiquinol (called Kaneka QH™).   Through a biological process that ferments natural CoQ10. Ubiquinol achieves higher elevations of circulating CoQ10 in the bloodstream with a much smaller dose than when using a ubiquinone CoQ10 supplement.

Daily Dose of Ubiquinol

More serious health conditions require greater CoQ10 doses.  Accumulating research indicates that the higher the dosage the greater the benefit and that the only limiting factor on the CoQ10 dosage is the cost, which is not cheap.

✔ Healthy person 20-30.   Shouldn't need to supplement CoQ10 at all, unless they are particularly active or have a condition causing lowered CoQ10 levels - in which case, they can take ubiquinone, since their body can convert it efficiently to ubiquinol;

✔ Healthy person 30-40.    50mg

✔ Healthy person in 40's and 50's  (To prevent heart attack).   100mg

✔ 60's and older / Tired / Taking a statin drug.   100-200mg

✔ Very sick.  Typically 200-300 mg split into 2 or 3 doses; Some examples of amounts used in studies: 390 mg dose used in breast cancer study,  1200 mg dose in Parkinsons disease;

The Kaneka Dosing Study of Kaneka QH ™

The study measured total CoQ10 concentration in human plasma for various dosage levels:Total plasma COQ10 concentration results were as follows:

Placebo (n=19), 90mg/day (n=20), 150mg/day (n=20), 300mg/day (n=19)

Began around 0.5 μg/ml for all participants and increased in a dose dependent manner;

Reached over 7 μg/ml at a dose of 300mg/day (~2.5 μg/ml at 90mg dose and ~3.5μg/ml at 150 mg dose)

Reached a plateau after about 2 weeks intake for all doses

Returned to base levels ~12 days after supplementation was stopped

Best taken with a meal containing fat

Works better when taken with a meal.    Even better if the meal contains fat in which to dissolve the CoQ10, and so provide better absorption.

Safety  

No adverse effects in studies.    Kaneka Q10 has been tested in dozens of safety studies up to clinical doses of 3,000 mgs per day, showing no adverse effects.

Boost your body's own CoQ10 production by supplementing with B6

100 mg Vitamin B6 / day

How is the status of CoQ10 assessed?

In humans, plasma or serum CoQ10 concentrations will serve as a good indicator of status.   The best way to assay CoQ10  by HPLC (high pressure liquid chromatography) by UV or electrochemical detection.

-   Plasma CoQ10 may not always reflect tissue status.   Localized deficiencies of CoQ10 may exist such as in the skeletal muscle or myocardial tissue whilst plasma concentrations may show “normal” values. If biopsy material is available, tissue CoQ10 analysis can yield more useful information

Steele PE et al, Clinical laboratory monitoring of coenzyme Q10 use in neurologic and muscular diseases. Am J Clin Pathol. 2004;121 Suppl:S113-20.

How are the body's CoQ10 levels affected by CoQ10 supplementation?

Normal serum/plasma CoQ10 concentrations.   In healthy people, usually range from 0.5 - 1.0 µg per mL. Total body CoQ10 is estimated at 1.5-2g.

After oral CoQ10 supplementation.   Plasma/serum concentrations reach a maximum after ~6 hours. The time to deplete to half-maximum concentration is ~34 hours. With the ingestion of high doses of CoQ10, plasma CoQ10 levels have been found to plateau after a dose of 2400 mg a day.

Shults CW et al, Pilot trial of high dosages of coenzyme Q10 in patients with Parkinson's disease. Exp Neurol. 2004;

CoQ10 in Skin Care

Mix ubiquinol into cream/lotion at 0.5% concentration.    After first dissolving it in a small amount of oil for a smooth texture to your finished product.

References

http://kenayag.com.pl/dok/Kan.pdf

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