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Cranial Electrotherapy Stimulation (CES)

Essential fatty acids (EFAs)

CHART of Essential Fatty Acid (EFA) Conversions in the body

CHART of body's EFA conversions to eicosanoids: PROSTAGLANDINS, LEUKOTRIENES and THROMBOXANES.

The balanced presence of eicosanoids in cell membranes determines how cells react to local problems

The eicosanoids are produced by omega-6 DGLA and AA, and omega-3 EPA present in cell membranes.  Eicosanoids from omega-6 AA mostly have inflammatory "call-to-action" effects, such as increasing pain, causing blood to clot, raising body temperature, and constricting vessels, and eicosanoids from omega-6 DGLA and omega-3 EPA have anti-inflammatory, "back-to-normal" effects. Excessive or unresolved inflammation can lead to uncontrolled tissue damage and health problems. 

Understand how "First Response" eicosanoids are VITAL FOR HEALTH

Δ6D and Δ5D enzymes Inhibited by:    dietary imbalance of Omega-6 to Omega-3, altered/damaged fats, cholesterol, excessive long-chain SFAs (in meat and dairy), age>30, sugar, stress, drugs, alcohol, toxic chemicals, caffeine, High INSULIN, excessive palmitoleic acids (Eg in coconut oil), lack of required conversion minerals/vitamins (see chart)

OMEGA-6
FAMILY
  OMEGA-3
FAMILY
LA
 (Linoleic Acid
 -  18:2w6)
In nut and seed oils,
animal fats (especially grain-fed),
spirulina,  wheatgerm,
 and legumes
ALA  
(α-Linoleic Acid
 -  18:2w3)
In Flaxseed, Chia seed,
Walnut & Hemp Oil,
 grass-fed animal fats


Converted by
 and
 COMPETING  for
 
 Δ6D enzyme
Requires:
 B6,
Magnesium,

Zinc
GLA (Gamma-linolenic Acid
 -18:3w6)
In Blackcurrant, Borage,
 and Evening primrose oils
  SDA  (18:4w3)
In Blackcurrant
 & other
 wild seed oils
Elongase Enzyme
DGLA (20:3w6):
In Mothers Milk
Most potent anti-inflammatory EFA
Eicosatetraenoic
 Acid

Preferred
 Pathway

blocks
LT4

Blocked by EPA
Converted by
and
 COMPETING for
 Δ5D enzyme

Requires
Vitamin C
, 
B3
, Zinc

 Δ5D
 Prefers
this Pathway



 
AA
(Arachidonic Acid
-
20:4w6 )
In Meat, Dairy, Eggs  
(major structural
component in body;
brain development
in infants)
Most potent
 inflammatory EFA
  EPA
(Eicosapentaenoic
 acid
20:5w3)
EPA (and DHA) 
In:
Fish oil,  grass-fed
 animal and poultry

 land animals' brains,
testes, adrenals,
eyeballs.
 Brown/red algae

COX-1
&
COX-2




COX-1
&
COX-2

5-LOX
(DGLA
derivative:
 15-
hydroxyl
blocks LT-4)
Belch, 2000)

COX-1
&
COX-2



5-LOX
 
Elongase
Docosa
-pentaenoic
Acid
PGG1

PGH1
PGG2

PGH2
    PGG3

PGH3
 

 ↕Δ4D
Prostanoids
Prostaglandins/Thromboxanes
Leuko-
trienes
Prostanoids Leuko-
trienes
DHA
(Docosa-
hexanoic
 acid
 22:6w3)

For brain
 and
 nerve
 function
(major
structural
component
in brain.
 40% of
 brain's
 membrane
phospholipid
 fatty acids)
S1
PGs:

PGA1
PGB1
PGC1
PGD1
PGE1
PGF1α

PGI1
TXA1
TXB1

(PGE1
PGF1α
TXA1
block
 LT4)
S2
PGs:

PGI2
(Prost
-acyclin)

PGD2
PGE2
(via PGE
synthase)

PGF2α
S2
Throm-
boxanes

TXA2
TXB2
S4
LTs

LTA4
LTB4
LTC4
LTD4
LTE4
(LTF4)

Eoxins
EX4
(from
LT4s
via
14,15
-LOX)
  S3
PGs:

PGD3
PGE3
PGF3α
PGI3
TXA3
(TXB3)
S5
LTs:

LTA5
LTB5
LTC5
LTD5
(LTE5)

Note on color-coding used throughout this site:

Enzymes:

"Lime green" for COX 1

"Purple" for COX-2

"Aqua" for LOX enzymes

Eicosanoids:

 Eicosonoids are color-coded according to their usual type of activity.  They are not necessarily differentiated as good and bad.

"Orange"  represents activity altering the status quo, some increasing inflammation.

"Turqoise" represents more of a "calming down" / going-back-to-normal action and/or resolving the inflammation.

"Red" represents eicosonoids having an inflammatory effect

 

Understand how these "First Response" eicosanoids are VITAL FOR HEALTH

COX: Cycloxygenase enzyme     LOX: Lipoxygenase enzyme

References

 Belch JJ, Hill A (Jan 2000). "Evening primrose oil and borage oil in rheumatologic conditions". Am. J. Clin. Nutr. 71 (1 Suppl): 352S-6S. PubMed.


DISCLAIMER: The content on this website is intended for informational, and educational purposes only and not as a substitute for the medical advice, treatment or diagnosis of a licensed health professional. The author of this website is a researcher, not a health professional, and shall in no event be held liable to any party for any direct, indirect, special, incidental, punitive or other damages arising from any use of the content of this website. Any references to health benefits of specifically named products on this site are this website author's sole opinion and are not approved or supported by their manufacturers or distributors.
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Pulsed Electromagnetic Field Therapy (PEMFT)

   Electrotherapy

       "The medical kit of the future"

The Body Electric

General electrotherapy health benefits.   Used systemically and/or locally at specific problem areas of the body, its effective application has many benefits:

Detoxification Wellness / Healthy aging Pain relief 
Relief from insomnia Immune system restoral Anti-Inflammatory
Maximizes cellular energy production Accelerated tissue /bone
/scar healing
Stress Reduction
Muscle relaxation / rehabilitation Increased blood oxygen
/ circulation
+++

There are several reasonably affordable electrotherapy devices available for personal use. The following electrotherapies are those that have received a significant amount of positive feedback:

Cranial Electrotherapy Stimulation (CES) applies specific frequency patterns to the head area, with the following benefits:

Balances neurotransmitters Relieves pain Treats depression
Substance abuse withdrawal Relieves insomnia Relieve stress / anxiety
Anti-Inflammatory Fibromyalgia +++