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Cox enzyme-inhibiting anti-inflammatory drugs

(e.g. Aspirin, motrin, Ibuprofen) produce unwanted side-effects

The COX-1 enzyme is normally present in sites where inflammation occur - and also in the stomach and other areas, where it produces the beneficial Series 3 prostaglandins (PG-3).

 

The COX-2 enzyme is only present in sites of inflammation.

  

Drugs (NSAIDS such as Aspirin, Motrin, Ibuprofen, and Naproxen) block both COX-1 and COX-2 - which inhibits:

 

- The negative Series 2 prostaglandins (PG-2)

 

AND

- The beneficial Series 3 prostaglandins - which for example, protect the stomach lining and maintain kidney function. The loss of such protection explains the unwanted side-effects of drugs such as:

 

Celebrex and Vioxx selectively block only the COX-2 enzyme - which inhibits ONLY:

- The negative Series 2 prostaglandins (PG-2)

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