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DIY SOLUTIONS FOR YOUR HEALTH
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Essential Fatty Acids for producing local hormones

(3) Local “Hormones” (Eicosonoids)

- “First Response Team” (Affects Inflammation/Pain, Muscles, blood pressure, clotting . . .)

 

   EICOSONOIDS produced from EFAs are the cell’s “First Response Team”

   Chart of EFA conversions to prostaglandins and leukotrienes

   EFFECTS of Prostaglandins and leukotrienes

 

EICOSONOIDS produced from EFAs are the Cell’s “First Response Team”

 

      If you are obtaining them - the 20-carbon-length EFAs (i.e. DGLA, AA, EPA) reside in the phospholipid bi-layer of the cell membrane and convert to eicosanoids (eico is Greek for 20).

 

      Eicosanoids are local scouts sent out from the cell to report back what's going on outside in its immediate environment - they enable the cell to take appropriately balanced action in response to any existing trauma or “happenings”.  Eicosanoids are similar to hormones, regulating and coordinating all cellular and body functions, but short-lived and operating only in their immediate locale.

 

      The best known eicosanoids are prostaglandins, leukotrienes, thromboxanes and prostacyclins - Each cell is able to control an appropriately balanced response to what is happening outside, by having a BALANCE of Omega-3 and Omega-6 fatty acids in its membrane, competing equally for enzymes, which convert them to derivatives, and finally to eicosanoids.

 

Reporting prostaglandins PG-1. PG-3 and leukotrienes LK-5 derived from fatty acids DGLA or EPA, work in opposition to eicosanoids PG-2 and LK-4 produced by AA to affect how the cells of a tissue or organ respond.

 

      Together they can:

 

         Increase or decrease inflammation and pain;

         Raise or lower blood pressure;

         Control uterine contractions;

         Dilate/Constrict blood vessels;

         Relax/contract muscles;

         Affect immune response;

         Affect blood clotting;

         Regulate nerve impulses, body temperature and fluid levels.

 

      Phospholipase A2 removes Omega-6 or Omega-3 fatty acids from the cell membrane

 

 

 

 

      Stimulated by physiologic events - the enzyme phospholipase A2 removes the Omega-6 or Omega-3 fatty acids from the cell membrane phospholipid bi-layer;

 

      These fatty acids then compete for other enzymes, which convert them to eicosanoids - E.g. Adequate EPA reduces the amount of enzymes available for conversion of AA to Series 2 Prostaglandins and Series 4 Leukotrienes.

 

CHART of EFA CONVERSIONS TO PROSTAGLANDINS and LEUKOTRIENES

 

OMEGA-6 FAMILY                                                                            OMEGA-3 FAMILY

LA (Linoleic Acid -  18:2w6)

In Nut & Seed oils, Spirulina, wheatgerm and Legumes

 

ALA (α-Linolenic Acid - 18:2w3)

 In Flaxseed, Chia seed, Walnut & Hemp Oil

 

             Converted by and competing for D6D enzyme            

 (Requires B6, Magnesium, Zinc)

 

GLA (Gamma-linolenic Acid – 18:3w6)

In Blackcurrant and Evening Primrose Oil

 

SDA  (18:4w3)

In Blackcurrant and other wild seed oils

 

Elongase

DGLA (20:3w6):

In Mothers Milk

 

Eicosatetraenoic Acid

(Preferred Pathway)                                                                                                        (D5D Prefers this Pathway)

         COX          1 : 1    Converted by and Competing for D5D enzyme                       

(Requires Vitamin C, Niacin (B3), Zinc)

 

POSITIVE

Series 1

Prostaglandins

(PG-1)

 

AA (Arachidonic Acid - 20:4w6 )

In Meat, Dairy,

Eggs

        

 

EPA (20:5w3)

EPA (and DHA) found in:     

Fish Oil. Grass-fed animals/poultry, land  

  animals’ brains, testes, adrenals, eyeballs. Brown/red algae

 

 

 

 

LOX

 

 

COX

 

 

COX

 

 

LOX

 

 

Elongase

    D4D

LOX - Lipoxygenase              enzyme

COX - Cycloxygenase   enzyme

 

INFLAMMATORY

Series 4

Leukotrienes

(LK-4)

 

NEGATIVE

Series 2

Prostaglandins

(PG-2)

 

POSITIVE

Series 3

Prostaglandins

(PG-3)

 

ANTI-INFLAMMATORY

Series 5

Leukotrienes

(LK-5)

 

DHA (22:6w3)

Most

important for brain and nerve function

 

 

From the above chart we can determine that for balanced prostaglandin and leukotriene production our diet needs to include:

 

      Vitamin B6 (Pyridoxine), Magnesium, Zinc, vitamin B3 (Niacin) and vitamin C - needed by the conversion enzymes D6D and D5D.

 

-       Note that arthritics are deficient in all 3 cofactors required for the D6D enzyme - i.e. B6, magnesium and Zinc.

 

 

      A balance of Omega-6 and Omega-3 fatty acids - since their presence affects the body’s production of eicosanoids, such as prostaglandins and leukotrienes, we therefore need to attend to the following:

 

-       Consume LA and/or GLA (or DGLA for baby drinking mother’s milk) - to produce the beneficial PG-1.

 

-       Reduce production of negative PG-2 and inflammatory LK-4, from AA, by either reducing AA consumption or countering its conversion to PG-2 and LK-4:

 

-      Since AA is the precursor to PG-2 and  LK-4, we need to moderate AA intake directly from food or AA derived from LA, GLA or DGLA i.e. a moderate consumption of AA from meat, dairy and eggs should be balanced by a source of EPA.

 

-      Consume ALA, SDA and/or EPA providing EPA to limit/counter the production of PG-2 and LK-4 from AA.

 

-       If not consuming marine-source omega-3 fatty acids - consume a balance of LA and ALA food sources and ensure a sufficiency of conversion enzymes:  Magnesium, Zinc, and Vitamins B3, B6 and C.

 

-       For optimal brain/nerve/reproductive/adrenal function, consume sufficient DHA in marine oil (E.g. Krill Oil) or consume ALA, SDA or EPA sources with sufficient zinc, B3 and C - to enable your body to either have or make DHA for your brain and nerve function.

 

 

EFFECTS of Prostaglandins (Series 1, 2 and 3) and Leukotrienes (Series 4 and 5)

This chart shows some effects of prostaglandins  PG-1, PG-2, PG-3 and leukotrienes LK-4; LK-5, helping us to realize the necessity for Omega-6 DGLA and AA to be present in the cell membrane in delicate balance with Omega-3 EPA.

“Series 1” Prostaglandins

PGE1

“Series 2” Prostaglandins

PGE2

“Series 3”

Prostaglandins

PGE3

Increase vasodilatation

Increase vasoconstriction

(& Series 5 Leukotrienes)

E.g.

Decrease pain

Increase pain

COUNTER INFLAMMATION

ENHANCE IMMUNE SYSTEM

Increase endurance

Decrease endurance

 

 

ENHANCE IMMUNE SYSTEM

 

SUPPRESS IMMUNE SYSTEM

By competing for conversion enzymes COX and LOX these Inhibit:

   Series 2 Prostaglandins

& Series 4 Leukotrienes

Increase oxygen flow

Decrease oxygen flow

 

Decrease cellular proliferation

Increase cellular proliferation

 

Prevent platelet stickiness

Create platelet stickiness (clotting)

 

Dilate airways

Constrict airways

COUNTER INFLAMMATION

INCREASE INFLAMMATION

Relax Muscles

Constrict Muscles

Increase urinary output

Decrease urinary output (fluid retentive)

Regulate Calcium Metabolism

“Series 4”

 Leukotrienes

Improve Insulin Regulation

INCREASE INFLAMMATION

 

EFA (Essential Fatty Acids) Related Links

 EFA Related Links

EFAs (Essential Fatty Acids)

EFAs – FATS of LIFE (Main Page)

        (Omega-3 and Omega-6)

EFAs = HEALTH

Anti-inflammatory EFAs help numerous health problems

EFA Deficiency Symptoms

Omega 6 / Omega 3 Imbalance

EFAs 5 Vital Functions

    -(1)  Cell Membrane Integrity

-(2)  Cellular Energy Production

-(3)  Local "Hormones" - affect pain, inflammatory reactions, muscle relaxation/contraction, immune response, nerve impulses, blood pressure, blood clotting, uterine contractions and more

 

NSAIDS – Unwanted affects on “local” hormones

-(4)  Systems Support

Blood Sugar
Brain / Nerves
Cancer Control
Cardiovascular
Immunity
Inflammation control
Reproduction
Skin
Kidneys/ Water retention

Vision

Growth and Repair

 -(5)  Child development

HOW TO GET EFAs

How to get the fats of life

HOW TO GET THE FATS OF LIFE (EFAs)     (Omega-3 and Omega-6) 

-     Vitamins and Minerals for effective use of EFAs Inhibitors of Conversion Enzymes for Omega-3 ALA and Omega-6 LA Fatty Acids

 

-   Damaged / Altered (Toxic)  Fats

 

-   The BUDWIG PROTOCOL

Enhance EFA delivery

   How to do the BUDWIG PROTOCOL 

(incl. Budwig Recipe)

    Daily Meal Plan for BUDWIG PROTOCOL - For cancer or other serious health conditions

    Eldi Oils in the BUDWIG PROTOCOL 

 

Omega-3 ALA (Alpha Linolenic Acid)

-    ALA Sources

 Flax Seed

 Chia Seed

 Hemp Seed

-   Omega-3 ALA - Omega-3 EPA/DHA

 Inhibitors to ALA Conversion 

-   Enhance Omega-3 ALA conversion to EPA/DHA

 Omega-3 EPA/DHA

-    EPA / DHA Sources

 Neptune Krill Oil (NKO)

(BEST CHOICE)

 Cod Liver Oil

(Low-heat processed)

 Fish

 -   Choosing a Marine Oil Supplement

(Fish oil not recommended) 

 Omega-6 GLA

-    GLA  Sources

 Borage, Blackcurrant and Evening Primrose Oils - For  Omega-6 DGLA

 

 

 

 

DISCLAIMER - The information given at this website is for research purposes only. It is not intended to diagnose or cure any mental or physical condition. It is not intended as a substitute for the advice of a licensed professional. In the event that you use this information for your own health, you are prescribing for yourself, which is your constitutional right as a U.S. citizen under Amendment IX of the U.S. Constitution, and for which the author of this information assumes no responsibility. The author of this information is neither a legal counselor nor a health practitioner and makes no claim in this regard. Any references to health benefits of specifically named products on this site are given as this website author's sole opinion and are not approved or supported in any manner by their manufacturers or distributors. COPYRIGHT 2009-2017