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Mg against Cardiovascular Diseas

Mg against Cardiovascular Disease

- Mg is the best heart medicine to prevent hypertension, stroke, angina, arrhythmia, heart attack, blood clots, etc.

Magnesium is required for healthy heart function

Mg deficiency is closely associated withCVD

A high calcium to magnesium ratio “Spells”CVD

Benefits of Mg in specific CVD problems

Transdermal delivery of magnesium chloride boosts Mg levels

to provide immediate cardiovascular benefits

(Used regularly, can sustain /supply beneficial Mg levels to your heart and circulatory system)

Transdermal Magnesium Chloride

“Magnesium deficiency appears to have caused eight million sudden coronary deaths in America during the period 1940-1994.”

- Paul Mason

Mg deficiency is closely associated with CVD

Harrison, Tinsley R. Principles of Internal Medicine. 1994, 13th edition, McGraw-Hill, pp. 1106-15 and pp. 2434-35

As magnesium intake fell during the 100 years since 1900, death from heart disease skyrocketed – adequate Mg levels are essential for proper heart function anda magnesium deficiency can cause the heart muscle to spasm or cramp and stop beating (i.e cardiac arrest).

Lower magnesium concentrations have been found in heart attack patients

Shechter, Michael, et al. The rationale of magnesium supplementation in acute myocardial infarction: a review of the literature. Archives of Internal Medicine, Vol. 152, November 1992, pp. 2189-96

A U.S. study of >10,000 people found that 79% were consuming less than the US RDA of Mg – further, 26% of the study participants were actually taking magnesium supplements and demonstrated lower levels of C-Reactive protein (a measure of inflammatory activity in the body and an accurate predictor of heart disease).

Source: US Study, reported in the July 2006 issue of the journalNutrition Research.

Appropriate magnesium supplementation can eliminate CVD related problems via several mechanisms:

–   Most importantly, magnesium prevents calcification of the heart tissues

–   Magnesium is required for muscle relaxation – Mg deficiency can result in symptoms of tachycardia, fibrillation, arterial constrictions, angina, even instant death.

–   Keeps blood flowing smoothly – by reducing platelet aggrevation/stickiness, Mg helps prevent the formation of blood clots.

Bo S, Pisu E. Role of dietary magnesium in cardiovascular disease prevention, insulin sensitivity and diabetes. Curr Opin Lipidol. 2008 Feb;19(1):50-6.

–   Magnesium dilates the heart arteries - both the epicardial and resistance coronary arteries. Mg produces vasodilation by both direct and indirect action –indirectly by sympathetic blockade and inhibition of catecholamine release.

–   Mg lowers LDL cholesterol levels/prevents atherosclerosis – Mg +ATP complex regulates cholesterol synthesis (by deactivating the rate-limiting enzyme HMG-CoA reductase required for its production). Mg also lowers inflammation, decreases oxidative stress, reduces homocysteine levels and diminishes endothelial dysfunction—all factors underlying CVD. Mg can raise HDL cholesterol, whilst lowering LDL cholesterol, since it is a cofactor of the enzyme LCAT which transfers part of one molecule to another resulting in the conversion of LDL to HDL. “The Magnesium Factor”by Mildred S. Seelig, Andrea Rosanoff (Note that adequate magnesium levels do not prevent the synthesis of cholesterol needed for healthy production of steroid hormones and vitamin D, since deactivated HMG-CoA reductase can be reactivated by other enzymes, some of which require magnesium for proper function).

–   Mg is essential for endocrine stability /function.

–   Mg is protective against metabolic syndrome and diabetes - major factors that threaten heart and vascular health.

A high calcium to magnesium ratio “Spells”CVD

Calcium must be balanced with Mg, (and also Vitamins A, D and K –all part of the calcium “team”) otherwise calcium causes calcification and arterial restriction.

High calcium levels (unbalanced by magnesium) constrict the heart arteries and increase the risk of heart attacks

–   Calcium deposits in the walls of the arteries contribute to the development of arteriosclerosis - arteries become hard and rigid, which restricts blood flow causing high blood pressure. Additionally, inelastic blood vessels can easily rupture, causing strokes.

–   Cardiovascular calcification lesions can lead to the development of CVD – including myocardial ischaemia, myocardial infarction, impaired myocardial function, congestive heart failure, cardiac valve insufficiency, and cardiac arrhythmias. There is a strong association between increased cardiac calcification and risk of death.

Countries consuming the highest calcium to magnesium ratios (high calcium and low magnesium levels) have the highest incidence of cardiovascular disease

–   Topping the list is Australia, then the U.S. and Scandinavian countries - in contrast, Japan with its low cardiac death rate cites a daily Mg intake as high as 560 mg, mainly from Mg in sea vegetables and single-cell algae, such as chlorella and spirulina, and also a variety of ocean-related food sources, including Nigari (magnesium chloride crystals that remain after sodium chloride is removed and water is evaporated from seawater) added to drinking water, miso soups, steamed vegetables, etc. and used as coagulants in the production of tofu. Additionally, the Japanese have one of the lowest intakes of calcium from dairy products.

–    Fatal heart attacks are more common in areas where the water supply is deficient in magnesium - and the average intake through the diet is often significantly less than the 200-400 milligrams required daily.

Eisenberg, Mark J. Magnesium deficiency and sudden death. American Heart Journal, Vol. 124, No. 2, August 1992, pp. 544-49

–   Studies show low incidence of high blood pressure and heart disease where Mg levels in drinking waterand food are high – Greenland natives, the Bantu of southern Africa, the Bedouin of the middle east and Aborigines of Australia were studied, but when these people moved to urban areas and began eatinga modern diet, they developed high blood pressure and heartdisease at similar rates to those in industrialized western countries.

Altura, B.M., B.T. "Magnesium in Cardiovascular Biology."Scientific American, Science & Medicine, May/June 1995:28-37.

Those who die from heart attacks have very low magnesium and high calcium levels in their heart muscles - CHD patients treated with high dose Mg survived better than those treated with other drugs. Intravenous Mg could save your life when administered during or shortly after a heart attack. (see below)

Study by Northwestern University School of Medicine, Chicago determined that insufficient dietary Mg increases your chances of developing coronary artery disease - in a study of 2,977 men and women, researchers used CT scans of the chest to assess coronary artery calcium levels. Beginning measurements were taken when the study participants were 18- to 30-years old—and again 15 years later. Results concluded that dietary Mg intake was inversely related to coronary artery calcium levels. Coronary artery calcium is considered an indicator of atherosclerosis, in which plaque build-up blocks arteries.

The ratio of calcium to magnesium is vital for cell membranes and the blood-brain barrier.

Benefits of Mg in specific CVD problems

Arrhythmias

Heart Attack

HBP

Angina

Congestive Heart Failure

Stroke

Mg prevents Arrhythmias

(heart palpitations/”flutters”/racing heart)

Numerous double-blind studies have shown Mg to be beneficial for many types of arrhythmias - including atrial fibrillation, ventricular premature contractions, ventricular tachycardia, and severe ventricular arrhythmias. Arrhythmias usually clear up on 500 milligrams of magnesium once or twice daily or faster if given intravenously.

Ott, Peter and Fenster, Paul. Should magnesium be part of the routine therapy for acute myocardial infarction? American Heart Journal, Vol. 124, No. 4, October 1992, pp. 1113-18

Dubey, Anjani and Solomon, Richard. Magnesium, myocardial ischaemia and arrhythmias: the role of magnesium in myocardial infarction. Drugs, Vol. 37, 1989, pp. 1-7.

England, Michael R., et al. Magnesium administration and dysrhythmias after cardiac surgery. Journal of the American Medical Association, Vol. 268, No. 17, November 4, 1992, pp. 2395-2402

Yusuf, Salim, et al. Intravenous magnesium in acute myocardial infarction. Circulation, Vol. 87, No. 6, June 1993, pp. 2043-46

Woods, Kent L. and Fletcher, Susan. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). The Lancet, Vol. 343, April 2, 1994, pp. 816-19

Mg depleted diet of postmenopausal women led to an increased occurrence of abnormal heart rhythms (supraventricular ectopy).

Klevay LM, Milne DB. Low dietary magnesium increases supraventricular ectopy. Am J Clin Nutr. 2002 Mar;75(3):550-4.

Mg protects against death from heart attack

Magnesium is significant protective factor against death from acute myocardial infarction – a Mg deficiency can cause the heart muscle to spasm or cramp and stop beating.

Am J Epidemiol 1996;143:456–62.

Intravenous Mg saves lives after heart attack

A 1995 study found that the in-hospital death rate of those receiving IV magnesium was a quarter of those who received only standard treatment - An 8 year follow-up study of these same patients revealed an enduring effect of magnesium treatment. Nearly twice as many patients in the standard treatment group had died compared to those who received magnesium, and there were considerably more cases of heart failure and impaired heart function in the placebo group. In addition to increasing survival after heart attack, IV magnesium smoothes out arrhythmias and improves outcomes in patients undergoing angioplasty with stent placement.

Manz, M., et al. Behandlung von herzrhythmusstorungen mit magnesium. Deutsche Medi Wochenschrifte, Vol. 115, No. 10, March 9, 1990, pp. 386-90

Iseri, Lloyd T., et al. Magnesium therapy of cardiac arrhythmias in critical-care medicine. Magnesium, Vol. 8, 1989, pp. 299-306

An analysis of seven major clinical studies shows that intravenous magnesium reduced the risk of death by 55% after acute heart attack - results were published in the prestigious "British Medical Journal" and the widely read journal "Drugs".

Teo KK et al., "Effects of intravenous magnesium in suspected acute myocardial infarction: overview of randomized trials."Brit Med J, vol. 303, pp. 1499-1503, 1991.

Teo KK, Yusuf S, "Role of magnesium in reducing mortality in acute myocardial infarction. A review of the evidence."Drugs, vol. 46, pp. 347-359, 1993.

Mg prevents high blood pressure (HBP)

Daily oral supplement of 625 mg of magnesium significantly reduced blood pressure – study involved 21 people

Montoyama, T., Sano, H., Fukuzaki, H. "Oral magnesium supplements in patients with essential hypertension."Hypertension, 1989;13(3):227-32

–   Daily oral Mg supplement of 411 - 548mg magnesium reduced bothsystolic and diastolic blood pressure - in a double-blind, placebo-controlled study

Itoh, K., Kawasaki, T., Nakamura, M. "The effects of highoral magnesium supplementation on blood pressure, serum lipids andrelated variables in apparently healthy Japanese subjects."British Journal of Nutrition, 1997;78(5):737-50.

–   70-80% of borderline hypertensive patients have significantly depressed blood-ionized magnesium levels - found Drs. Burtonand Bella Altura, two of the leading researchers in the field of magnesium

Altura, B.M., B.T. "Magnesium in Cardiovascular Biology."Scientific American, Science & Medicine, May/June 1995:28-37.

Mg prevents angina pain

Mg Prevents angina paindue to either coronary artery muscle spasms or atherosclerosis

61% of mitral valve prolapse (MVP) patients shown to have low Mg levels compared to 5% of control group –study involved patients with strongly symptomatic MVP, who after 5 weeks of Mg supplementation had a 50% on reduction of symptoms of chest pain, palpitation, anxiety, low energy, faintness, and difficulty breathing.

(MVP is a disorder where the mitral valve of the heart fails to completely close off one of the chambers in the heart during contraction).

Mg is a life-saver for those with Congestive Heart Failure (CHF)

(Weakened heart muscle is not pumping enough blood to meet the body's needs)

Controlled/double blind study findings suggest a powerful role for Mg supplementation as an adjuvant therapy to improve survival and lessen symptoms for CHF patients - 79 patients received either Mg supplements or placebo, along with optimal cardiovascular medication, for one year. For the first month, the Mg group received 390 mg elemental Mg, and 195 mg during the following 11 months. At on year, only 52% of the placebo group was still alive, compared with 76% of the Mg group.

Stepura OB, Martynow AI. Magnesium orotate in severe congestive heart failure (MACH). Int J Cardiol. 2008 Feb 15

CHF patients admitted to hospital had higher baseline CRP levels/lower serum Mg levels than non-CHF patients administering Mg to CHF patients increased their intracellular Mg levels and decreased CRP levels, suggesting an improvement in prognosis for these CHF patients. (C-Reactive Protein (CRP) is a reliable indicator of CVD presence)

Almoznino-Sarafian D, Berman S, Mor A, et al. Magnesium and C-reactive protein in heart failure: an anti-inflammatory effect of magnesium administration? Eur J Nutr. 2007 Jun;46(4):230-7.

IV cocktail including magnesium chloride has shown effective results with CHF – according to John R. Gaby, former President of the American Holistic Medical Association, in "Alternative Medicine: The Definitive Guide"

Stroke

Mg can help heal the damage in the brain caused by a stroke - in his book “Transdermal Magnesium Therapy”, Dr. Mark Sircus states that magnesium may reduce ischemic injury by increasing regional blood flow, antagonizing voltage-sensitive calcium channels, and blocking the N-methyl-D-aspartate (NDMA) receptor. As a non-competitive NMDA receptor blocker, magnesium inhibits the release of excitatory neurotransmitters at the presynaptic level and blocks voltage-gated calcium channels. Magnesium simultaneously exerts vascular effects, including increased vasodilation and cardiac output, and prevents cerebral vasospasm. Dr. Sircus points out that transdermally applied magnesium chloride offers advantages over other neuroprotective agents (such as intravenously administered magnesium sulfate) for preventing strokes. These advantages include lower cost, ease of use, and lack of side effects, asserting that a gallon and a half of low cost magnesium chloride “would do more to prevent strokes safely without side effects, than any other single medicine”, but also that when “used transdermally after a stroke will reduce disability”. Magnesium chloride administeredimmediately following a stroke (or heartattack) dramatically improves your chances of a full recovery.

98 stroke patients admitted to the emergency Room of three hospitals in New York exhibited early and significant magnesium-ion deficits - the stroke patients also demonstrated a high calcium to magnesium ratio, which are signs of increased vascular tone and cerebral vessel spasm.

Altura BT et al., "Low levels of serum ionized magnesium are foundin patients early after stroke which result in rapid elevation incytosolic free calcium and spasm in cerebral vascular musclecells."Neurosci Lett, vol. 230, no. 1, pp. 37-40, 1997.

Higher Mg levels in drinking water used by Taiwan residents, lowered the incidence of stroke - all deaths due to stroke among Taiwan residents (17,133 cases) from 1989 through 1993 were compared with deaths from other causes (17,133 controls).

Source: Yang CY, "Calcium and magnesium in drinking water and risk of death from cerebrovascular disease."Stroke, vol. 18, no. 8, pp. 411-414, 1998.

Magnesium Links

MAGNESIUM*

Related Links

MAGNESIUM

Mg - Missing Miracle Mineral

MAGNESIUMDEFICIENCY

Why are we Mg-Deficient?

- Signs of Magnesium Deficiency

-Magnesium Deficiency Questionaire

MAGNESIUM FUNCTIONS

Mg Functions in the Body

- Mg - Activates Vitamin D

-Mg - Alkalizing Agent

- Mg - Anti-Inflammatory

- Mg –Detoxifies Cells of Toxic Metals/Other toxins

- Mg –Regulates Calcium
Prevents soft tissue calcification

- Mg –Over 300 Enzymes

- Mg –Cell “Battery”/ATP Production

- Mg –Cell Membrane Integrity

- Mg –Antioxidant Glutathione synthesis

- Mg –Hormonal balance

- Mg –Cellular and food metabolism

- Mg –Muscle Relaxant

Mg effects on cardiac system

Mg in skeletal muscle contractions

- Mg –Calms Nerves

MAGNESIUM'S MANY HEALTH BENEFITS

The Many Health Benefits of Mg

- Mg - For Bones

-Mg –Against Cancer

- Mg –Against CVD

–    Mg –Against Dental Problems

- Mg –For Mental Well-Being

-Mg –Against Diabetes

- Mg –Against Estrogen Dominance

–    Mg - Fights Infection /Immune System booster

- Mg –Dissolves Kidney Stones(calcium oxalate)

- Mg –Prevents /Alleviates Migraine

- Mg - Against Neurological/Neuromuscular Conditions

- Mg - Against Pain

- Mg - For Skin and Hair

- Mg - For Surgery

MAGNESIUM SUPPLEMENTATION

How to supplement MAGNESIUM

- Transdermal Magnesium Chloride

How to Make Magnesium Chloride Oil

Some Mg. Chloride Chemistry

-Oral Mg Supplementation

- Nebulizing/Vaporizing MgCl2

–    How much MAGNESIUM should I Supplement?

FOOD SOURCES OF MAGNESIUM

Mg Food Sources

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