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GSE MELATONIN Health Benefits

MELATONIN Health Benefits

MELATONIN is a powerful antioxidant

MELATONIN helps protect the body from cell damage caused by free radicals:

–    Direct scavenger of OH (hydroxyl radical),O2•-(superoxide radical), and NO (Nitric oxide), ONOO-(Peroxynitrite anion), 1O2 (singlet oxygen), and possibly LOO(peroxyl radical);

–   Neuroprotective - Can easily cross cell membranes and the blood-brain barrier.

Kilic E, Özdemir YG, Bolay H, Kelestimur H, Dalkara I. Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia. J Cerebr Blood Flow Metab 19:511–516, 1999.Medline

Baydas, G., H. Canatan and A. Turkoglu, 2002. Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin induced diabetes mellitus. J. Pineal Res., 32: 225-230.PubMed

–   “Suicidal antioxidant”- unlike other antioxidants (such as vitamin C), MELATONIN can not be renewed (i.e. it does not undergo redox cycling, the ability of a molecule to repeatedly undergo reduction and oxidation to regain antioxidant property).

–   Demonstrated to prevent some carcinogenic damage to DNA - Stops mechanism by which damaged DNA causes cancer.

–   Increases body's "in-house" antioxidant glutathione - and is equally effective to this important antioxidant

–   Debated as equal to vitamin E as a chain-breaking antioxidant against peroxyl radical - produced by lipid peroxidation, which e.g. damages cell membranes altering cellular function. The resulting cell membrane rigidity associated with aging;

–   Scavenges initiating radicals and breakdown products from lipid peroxidation - assured by the fact that it scavenges 1O2, ONOO-and OH, all of which are sufficiently reactive to initiate the peroxidative process. Prevents otherwise harmful changes to membrane fluidity and function.

–    Greatly reduced inflammatory response - where both ONOO- and NO are believed to be the mediators of the inflammation in animals treated with carrageenan

Beckman J.S., Koppenol W.H. Nitric oxide, superoxide, and peroxynitrite: The good, the bad and ugly// Am. J. Physiol.-1996

 

–   Protected against brain injury caused by ROS release in newborn rats

–   May reduce damage caused by some types of Parkinson's disease

–   May play a role in preventing cardiac arrhythmia

–   May increase longevity - shown to increase average life span of mice by 20% in some studies.

–   Protects against sunburn – scientists at University of Zurich found that MELATONIN protects against UV radiation if topically applied before skin exposure;

–   Role in repairing burned skin - In a study in Brain Research Bulletin, MELATONIN levels rose six hours after burn injury, then fell to normal.

–   May prevent cataract formation

–   In small amounts, causes skin cells to proliferate – in large amounts it stops proliferation. People with psoriasis and atopic eczema have peak MELATONIN in the day (instead of at night), and low levels at night; not too surprising in that some scientists consider the skin to be another gland.

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