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GSE ESTROGEN DOMINANCE - How to Reduce Estrogen in the Body

Reduce Estrogen Levels in the Body

Reduce estrogenic intake

Inhibit estrogen production

Reduce Xenoestrogen Exposure

Help Liver to better eliminate estrogen

MODERATELY Supplement diet with Plant Estrogens (Phytoestrogens) ( anti-estrogenic effect)

Some drugs inhibit estrogen

Eat your crucifer vegetables!

Several health problems are associated with an estrogen dominance effect –whereby an imbalance of estrogen over PROGESTERONE in women (or TESTOSTERONE in men) is having an overall estrogenic effect. The most well-known repercussion of this is to cause overproliferation of cells in many reproductive cancers and female issues, such as polycystic ovarian syndrome, ovarian fibroids,fibrocystic disease of the breast.

For more detailed information on why we need to reduce estrogen levels to resolve a situation of estrogen dominance:

Why has Estrogen Dominance become so Prevalent

Reduce Estrogenic Intake

Moderate intake of plant estrogens

Eat only moderate amounts of ORGANIC soy and flax

Avoid concentrated soy products - in fast food meals and other processed foods, protein powders, bars, and soymilk. Note that >90% of U.S. soy is genetically modified and showing detrimental effects on our reproductive and immune systems.

HARMFUL INGREDIENTS –Genetically Modified Food

Minimize caffeine consumption

Minimize caffeine in tea, coffee, soft drinks etc. - caffeine is a CNS stimulant linked to higher estrogen levels. Studies have shown that women who consumed > 500 mg of caffeine daily (~4 or 5 cups of coffee, had ~70% more estrogen during the early follicular phase than women who consume < 100 mg of caffeine daily (~ 1 cup of coffee).Fertility and Sterility 2001;76:723-729.

Avoid Estrogen-containing medications

Estrogen-containing medications - includes estrogen-containing drugs (E.g. Hormone Replacement Therapy, Birth Control pills, steroids, ulcer medications (e.g. cimetidine), some antibiotics (E.g. tetracycline, ampicillin), anti-fungal medications and antidepressants.

Inhibit Estrogen Production

Lower production of/Inhibit aromatase enzyme

Increase MELATONIN levels

Avoid boron supplements

Lower production of / Inhibit aromataseenzyme

The aromatase enzyme is required to facilitate the conversion of TESTOSTERONE or ANDROSTENEDIONE to estrogen in the ovaries of reproductive age women, male testes, or adipose tissue from older or obese men or women.

Reducing body fat decreases aromatase production by adipose tissue

Aromatase-inhibiting foods:

✔ Fruits: Berries, citrus fruits, pears, pineapples, grapes, melons, figs, pomegranates, but NOT apples, cherries, dates

✔ Vegetables: Green beans, squashes, onions

✔ Grains: millet, corn, tapioca, rice, flour

PROGESTERONE –inhibits the transcription of the aromatase gene by interaction with the glucocorticoid receptor in adipose tissue in a dose-dependent manner. The absence of PROGESTERONE receptors in adipose fibroblasts enables PROGESTERONE to inhibit glucocorticoid-dependent aromatase induction. It is proposed that it is a suppressor of aromatase induction in adipose tissue in premenopausal women.

Schmidt M, et al, PROGESTERONE inhibits glucocorticoid-dependent aromatase induction in human adipose fibroblasts, J. of Endocrinology, 1998

Resveratrol - is a partial ER agonist (i.e. activates ER receptors), and yet acts as an ER antagonist in the presence of estrogen leading to inhibition of human breast cancer cells.

Zinc – is a natural aromatase inhibitor ;

Pomegranate – ellagitannins (Ellagic acid) found in pomegranates inhibit aromatase; Urolithin B, a metabolite produced from ellagic acid, significantly inhibited cell growth in estrogen-responsive cancers.

Flavones and Isoflavones - have been shown to be aromatase inhibitors;

–   White Button Mushrooms

Grube, Baiba J, White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation. J. of Nutr., 2001;

Chen S et al, Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus)", Cancer Res. ,2006

–   Chrysin + Piperine – chrysin is a non-estrogenic flavone derived from the Passiflora plant (passion flower) and found in honeycomb in small amounts, has not proved to be an effective aromatase inhibitor when taken (orally) alone. A 1999 study [Biochemical Pharmacology, 1999, Vol.58]identified chrysin's poor absorption in the bloodstream. However, pilot studies have found that when chrysin is combined with piperine, reductions in serum ESTRADIOL and increases in total and free TESTOSTERONE result in 30 days. Chrysin may also work as an aromatase inhibitor if taken in combination with citrus bioflavanoids, the way they appear in nature. To be effective alone, chrysin needs to be absorbed topically in a cream, or absorbed through mouth mucosa by sucking a lozenge.

–   Luteolin - most often found in leaves, but also in celery, thyme, green pepper, perilla, chamomile tea, carrots, olive oil, peppermint, rosemary, oregano, dandelion, rinds,barks, clover blossom and ragweed pollen. Also isolated from Salvia tomentosa.

–   Kaempferol – natural flavonoid has been isolated from tea, broccoli, Brussels and apples; extracted from delphinium, witch-hazel and grapefruit, but requires high concentration for anti-aromatase effect not likely achieved except via extraction.

–   Quercetin - inred wine,inhibits aromatase;

–   Soy isoflavones- specifically genistein and daidzen are known to be potent aromatase inhibitors.Soy isoflavones at moderate doses are mildly estrogenic by binding to the ESTRADIOL receptors in the tissues and thus blocking ESTRADIOL (the more potent estrogen hormone). Also, soy isoflavone supplementation was shown to significantly increase sex hormone binding globulin (SHBG, the protein that binds /inactivates estrogen in the blood) in postmenopausal women with low initial SHBG levels, thereby reducing free estrogen.

Dietary Isoflavones Affect SHBG Levels in Postmenopausal Women, Pino AM et al, J. Clin. Endocrinol. Metab. 2000 85: 2797-2800, doi: 10.1210/jc.85.8.2797

However, HIGH soy isoflavone intake will have an estrogenic effect and researchers From the University of Illinois, Virginia Polytechnic and State University and the National Center for Toxicological Research, article in the journal Carcinogenesis found that when patients taking a drug used against estrogen-dependent breast cancer also took genistein, it reduced the effectiveness of the drug. i.e. tumors began to grow again, growing fastest at the highest doses of genistein.

–   Combination of Citrus bioflavonoids + Soy Flavones - Experiments conducted in Italy have shown that combining citrus bioflavonoids with soy flavones creates a more powerful defense against estrogen than taking soy flavones or citrus flavonoids alone.Citrus flavonoids are abundant in the white, spongy layer of citrus peels.

Flaxseed lignans may be anti-aromatase - Flaxseed lignans are found in the fibrous part of flaxseed, and according to Udo Erasmus phD, a leading expert on fats, they contain anti-estrogenic properties.It's unclear whether they work by solely blocking estrogen receptors, or by blocking the aromatase enzyme as well.However, lignans have shown positive results as a natural aid against estrogen-related problems.The best, natural source of flaxseed lignans is ground flaxseed (i.e. flaxmeal).

Stinging nettle (extract) is anti-aromatase:


–   Aphrodisiac effect on men by increasing the level of free TESTOSTERONE in the blood - contain compounds that bind to SHBG, reducing the binding of TESTOSTERONE to SHBG;

–   Blocks binding of growth-stimulating Estrogen to prostate cells – Useful in treating benign prostatic hypertrophy (BPH);

–   Natural aid for women who suffer from Estrogen -related stubborn fat.

Drugs – Aramidex

Increase MELATONIN levels

One of MELATONIN's roles is the reduction of Estrogen production in the body - and probably also reduction of the number of estrogen receptors (ERs). MELATONIN is produced in total darkness (usually during sleep) and is significantly reduced by excessive exposure to light (including late night TV viewing).


Avoid Boron Supplements

Supplementing boron raises estrogen levels – even at the typical supplementation dose level of 3mg, boron can increase estrogen production in the body. High levels of boron also affect the absorption of calcium, magnesium, and phosphorus.

Collins, J. 2000. What's your menopause type? Prima Health, Roseville, Calif.

Reduce Xenoestrogenic Exposures

Note that reducing xenoestrogen levels in the body is a long term process achieved by reducing xenoestrogen exposure

Some examples given here, but for more details, see:

Xenoestrogens –Endocrine Disruptors


Avoid - #3 Vinyl/PVC and #7 OTHER (usually polycarbonate), which are estrogenic.

OK-Non-Estrogen ic plastics - PETE, HDPE, LDPE, Polypropolene and Polystyrene do NOT contain phthalates or use BPA during production (polymerization) or package-forming.

Children / Babies

Use glass baby bottles – not #7 polycarbonate; heating milk in them leaches even more BPA;

Do not use PVC bottle nipples or teethers

Throw out PVC (squeezy) toys

Use powdered baby formula instead of cans – to reduce Biphenol-A exposure; breast-milk is the best choice.


Preferably eat organic meat and produce / wash fruit and vegetables – the feed of non-organically raised animals contain hormone-disrupting toxins including pesticides, herbicides, synthetic or “bio-solid”(recycled human excrement) fertilizers, antibiotics, and drugs to combat disease when so many animals are packed closely together. Produce with the most pesticides reported inA Shopper's Guide to Pesticides in Produceincludestrawberries (contain vinclozolin, a known endocrine disruptor), bell peppers, peaches, apples, apricots, and spinach.Foods with the least amount of pesticides include avocados, corn, onions, sweet potatoes, bananas, green onions, broccoli, and cauliflower.

Trim fat from meat and skin from poultry and fish that tend to store toxins

Use rBGH-free milk and dairy / Eat growth hormone-free meat – Estrogenic growth hormones are commonly injected into and fed to livestock

Moderate coffee/tea drinking - to limit estrogenic caffeine intake;

Home filter your water to remove hormones – such as synthetic estrogens from the urine of women taking HRT and birth control pills that are flushed down the toilet, eventually finding their way back into our water and food supply.

Store/Heat food and liquids in glass or ceramics – heated #3 plastics leach very quickly into food; most food-services use plasticized #3 cling-wrap containing phthalates.

Choose packaged goods in glass or paper containers

Eat mostly fresh foods - cut back on processed and pre-packaged foods in general;


Don't overheat Teflon pan(preferably don't use at all) – if its smoking it's poisoning you;

Eat wild fish – less contaminated than farmed fish; choose an effective Omega-3 supplement uncontaminated by PCBs and mercury;

How-to Supplement Essential Fats


Use parabens-free, natural ingredient, non-toxic cosmetics;

Use natural soap, shampoo, toothpaste, anti-perspirant, lotions, perfumes and other toiletries – check out this site for help choosing personal care products;

Nail polish and remover – acetone is a xenoestrogenic solvent;

Use condoms without spermicide (xenoestrogenic) for birth control – instead of birth control pills;


Use non-toxic, environmentally safe, “green”detergents, fabric softeners, dishwashing detergent, cleaning products –with less chemicals; do away with the fragranced dryer sheets;

✔ Avoid artificial air-fresheners – use essential oils in a diffuser or lightly heated;

✔ Avoid lawn and garden sprays, indoor insect sprays use natural herbicide/pesticide control, such as grapefruit seed extract, hydrogen peroxide,1 Cup salt in 1 gallon of vinegar, or other alternatives;

✔ Minimize exposure to synthetic chemical solvents E.g. methanol, aldehydes, ketones in paints, paint remover, varnishes, glues, cleaning products, carpet, fiberboard, other processed woods;

✔ Don't dry-clean clothes

✔ Replace vinyl shower curtain with fabric one

✔ Don't use vinyl wallpaper

✔ Replace Teflon pots/pans with ceramic, glass or stainless steel cookware

Help Liver Better Eliminate Estrogen

Detoxify the liver

The liver eliminates estrogens through bile and urine - To promote sufficient bile flow and enable the liver to metabolize and clear estrogen effectively, one should cleanse the liver:

–   Use liver cleansing substances

✔  Coffee Enema

✔ Herbs -milk thistle, dandelion root;

✔  SAMe - And other Methyl Donors;

✔ Combination of Chinese Bitters(before breakfast) + Coptis - eliminate estrogens. Coptis is an effective bile stimulator.

–   Daily morning exercises - such as stretching and deep breathing can also help by "activating" the liver.

–   Avoid drugs, alcohol, toxins, which impair liver function - The liver's ability to cleanse the blood of estrogen is compromised when the liver has to work hard to eliminate toxins. The use of anabolic steroids, marijuana, cocaine, caffeine and other drugs or environmental agents can affect hormone levels. Excessive alcohol intake can increase the body's conversion of TESTOSTERONE into estrogen, especially in fat cells. It can also block the liver from effectively breaking down/eliminating excess estrogen.

–   Decreased clearance rate ofestrogensby the liver could be due to organic lesions such as cyrrhosis


Ensure sufficient B-vitamins and Magnesium

B vitamins (B6 in particular) and Magnesium have important roles in estrogen metabolism/clearance by the liver – i.e. a deficiency in either reduces liver's estrogen clearance rate.

Magnesium and B Vitamins for estrogen clearance

Moderately supplement diet with phytoestrogen foods

Phytoestrogens mimic body estrogens - The similarities, at molecular level, of body-produced estrogen with its corresponding plant version, allow them to mildly mimic and sometimes act as antagonists of the hormone

Phytoestrogens, wikipedia


How Much Dietary Phytohormone content is good for You? - An epidemiological study of women in the U.S. found that the dietary intake of phytoestrogens in healthy post-menopausal caucasian women is < 1 mg/day.

de Kleijn MJ, van der Schouw YT, Wilson PW, Adlercreutz H, Mazur W, Grobbee DE, Jacques PF. Intake of dietary phytoestrogens is low in postmenopausal women in the United States: the Framingham study(1-4). J Nutr. 2001 Jun;131(6):1826-32. PubMed

Some plant constituents mildly mimic estrogen by binding to their receptors (ERs) – this function can be utilized to reduce the effect of estrogen . Phytoestrogens are able to “dock”onto the estrogen receptor (ER), but produce a weaker response than estrogen

–    Phytoestrogenic foodsbut should only be consumed in moderate amounts:

✔ Beans, flaxseed and soy

–   Herbs with estrogenic action - the six highest commonly used ER-binding herbs:

✔ Licorice, red clover, thyme, turmeric, hops, and verbena

Some Drugs Inhibit Estrogen by Various Methods

Fulvestrant (Faslodex®) - eliminates the estrogen receptor;

Tamoxifen and toremifene (Fareston) - work by temporarily blocking estrogen receptors on breast cancer cells, preventing estrogen from binding to them.

Eat Your Crucifer Vegetables!

Indole-3-carbinol (I3C) (found substantially in broccoli, cabbage, kale, Brussels sprouts, and other crucifers) - increases the conversion of ESTRADIOL to a “weaker”estrogen (2OHE). The body converts I3C to diindolylmethane (DIM), which then induces certain enzymes in the liver to block the production of the toxic estrogens and step up the production of the beneficial forms. To protect I3C levels, the best way to eat them is lightly steamed or even better, pickled;Helpful for those with "allergies", asthma, chronic fatigue, or MCS.

DIM can be taken as a supplement – for information on its health effects and how to supplement:

DIM - Estrogen blocker with Anti-Cancer Benefits

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