How does MELATONIN exert its effect to aid sleep?
MELATONIN exerts its biological effects primarily by two methods:
1. Via activation of MELATONIN receptors
2. In its role as a powerful antioxidant;
MELATONIN has 3 cell-signaling actions:
✔ Endocrine – secreted by pineal gland into bloodstream
✔ Autocrine – MELATONIN binds to receptors of same cell which secreted it
✔ Paracrine – secreted by tissues/cells to act on local target cells
MELATONIN is involved in the regulation of seasonal and circadian fluctuations of other hormones/neurotransmitters:
MELATONIN promotes or inhibits synthesis/secretion of other hormones/neurotransmitters
LEPTIN is downregulated by MELATONIN, except in the presence of INSULIN, which increases LEPTIN; LEPTIN is secreted by adipocytes and is called the appetite suppressant hormone, informing the brain about the body's overall adipose tissue, which role determines energy homeostasis in the body.
With INSULIN, MELATONIN increases LEPTIN ▲ , suppressing appetite▼ during sleep, so you stay asleep instead of being hungry all night. In a feedback loop: LEPTIN tells your brain you are not hungry, such that you stay asleep and make more MELATONIN
GnRH -Down-regulates GnRH mRNA Ãª production in hypothalamic GnHR-secreting neurons –a link to sexual development and puberty.
Reciprocal with CORTISOL – which rises in the morning to its highest levels(ready for you to face the day),as MELATONIN declines (so you can wake up);
Other hormones involved
Gonadal steroids, pituitary gonadotrophins, thyroxine, and the adrenal hormones
Spiegel K, Leproult R, Van Cauter E. [Impact of sleep debt on physiological rhythms]
[Article in French]. Rev Neurol (Paris). 2003 Nov;159(11 Suppl):6S11-20.
Attend to Diet, Lifestyle and Emotional State
"The medical kit of the future"
General electrotherapy health benefits. Used systemically and/or locally at specific problem areas of the body, its effective application has many benefits:
|Detoxification||Wellness / Healthy aging||Pain relief|
|Relief from insomnia||Immune system restoral||Anti-Inflammatory|
|Maximizes cellular energy production||Accelerated tissue /bone /scar healing||Stress Reduction|
|Muscle relaxation / rehabilitation||Increased blood oxygen / circulation||+++|
There are several reasonably affordable electrotherapy devices available for personal use. The following electrotherapies are those that have received a significant amount of positive feedback:
* Cranial Electrotherapy Stimulation (CES) applies specific frequency patterns to the head area, with the following benefits:
|Balances brain neuro-transmitters||Relieves pain||Treats depression|
|Substance abuse withdrawal||Relieves insomnia||Relieve stress / anxiety|