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GSE MELATONIN Health Benefits

MELATONIN enhances bone mass

Bone health.     Bone resorption is a process by which osteoclasts break down bone and release the minerals. MELATONIN has been shown to inhibit bone resorption and increase bone mass through its ability to down-regulate activation of osteoclasts.

Pandi-Perumal SR, Srinivasan V, Maestroni GJ, Cardinali DP, Poeggeler B, Hardeland R. MELATONIN: Nature's most versatile biological signal? FEBS J. 2006 Jul;273(13):2813-38. PubMed

An adequate amount of ESTRADIOL is also needed for MELATONIN to benefit bone (a salivary ESTRADIOL test may be useful in cases where MELATONIN is low and bone loss is a concern).High CORTISOL levels also contribute to bone loss.

Raff H, Raff JL, Duthie EH, Wilson CR, Sasse EA, Rudman I, Mattson D. Elevated salivary cortisol in the evening in healthy elderly men and women: correlation with bone mineral density. J Gerontol A Biol Sci Med Sci. 1999 Sep;54(9):M479-83. PubMed

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