Benefits of MELATONIN Supplementation
Benefits of MELATONIN
- Study Supported
read about the many health benefits of MELATONIN:
MELATONIN Health Benefits
Supplementing with MELATONIN is appropriate
in certain situations
– but be aware that chronic use
of supplemental MELATONIN
in younger people can result in
the pineal gland becoming lazy
To synchronize perturbed sleep and circadian rhythms
Prevent ischemic damage
Against cardiovascular disease
Learning, memory and Alzheimer's
Migraines / Headaches
Protection from radiation
For older people
( > 60 yrs)
supplementation can be useful, since their pineal gland is not producing enough
To synchronize perturbed sleep and circadian rhythms – sustained desynchonisation of the
“Biological Clock” has a profound impact on health and wellbeing, including
suppressed immunity and increased risk of cancer. Also, frequently accompanying
these disturbances are neuropsychiatric disorders, such as depression,
schizophrenia and Alzheimer's. Desynchronisation occurs while the body's clocks
struggle to adapt to an abruptly shifted external light/dark cycle. E.g.
travel – (Jet Lag) – E.g. Transcontinental
flight personnel and frequent overseas fliers. Supplement
MELATONIN on the day of the flight and
continue for five days thereafter.
MELATONIN supplements may simulate the MELATONIN
production at different times that does not occur during regular sleeping hours
for people who work night shifts.
Straif, Kurt; Baan, Robert; Grosse, Yann; Secretan, BéAtrice; Ghissassi, Fatiha
El; Bouvard, VéRonique; Altieri, Andrea; Benbrahim-Tallaa, Lamia et al (2007).
"Carcinogenicity of shift-work, painting, and fire-fighting". The Lancet
Oncology 8 (12): 1065–6.
Prevent ischemic damage –
in rats, reduces tissue damage due to ischemia in brain and heart;
(ischemia is a restriction in blood supply causing a shortage of oxygen delivery
to target organs/tissues)
Against cardiovascular disease –
Low nighttime MELATONIN has been
reported in patients with coronary heart disease and heart failure. Similarly,
the link between high CORTISOL
and hypertension is well established. Supplementation with
MELATONIN has been shown to increase cardiac
vagal tone, decrease circulating NOREPINEPHRINE, and reduce blood pressure.
Nature's most versatile biological signal?
Learning, memory and Alzheimer's -
first published evidence that
MELATONIN may be useful in Alzheimer’s
disease demonstrated that this neurotransmitter/hormone prevents neuronal death
caused by exposure to the amyloid beta protein, a neurotoxic substance that
accumulates in the brains of patients with the disorder.
isoproterenol-induced tau hyperphosphorylation by
in the rat.Sheng Li Xue Bao. 2005 Feb
MELATONIN also inhibits the aggregation of the amyloid beta protein into
neurotoxic microaggregates which seem to underlie the neurotoxicity of this
protein, causing death of neurons and formation of neurofibrillary tangles, the
other neuropathological landmark of Alzheimer's disease.
prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide.
1997 Mar 1;17(5):1683-90.
that after MELATONIN is administered to ADHD
methylphenidate, the time needed to fall asleep is significantly reduced.
Furthermore, the effects of the MELATONIN
after three months showed no change from its effects after one week of use.
Pian Gi, Cecil V.; Broeren, Joris P. A.; Starreveld, J. Sander; A. Versteegh,
Florens G (2003). "MELATONIN
for treatment of sleeping disorders in children with attention
deficit/hyperactivity disorder: a preliminary open label study”. European
Journal of Pediatrics 162 (7–8): 554–5.
Migraines / Headaches - several clinical studies indicate that
MELATONIN supplementation is an effective
preventative and adjunct
treatment for migraines and cluster headaches.
Treatment and Management of Cluster
The therapeutic potential of MELATONIN in
migraines and other headache types.
Mood disorders -
MELATONIN has been shown to be effective in treating seasonal affective disorder
(SAD) and is being considered for bipolar and other disorders in which circadian
disturbances are involved.
Is Internal Timing Key to Mental Health?
Depression - research shows that depressed patients have lower levels of
MELATONIN than non-depressed patients,
however, although MELATONIN
supplementation helps correct sleep disorders in depression, it does
not improve clinical symptoms of depression.
MELATONIN: Nature's most versatile biological
FEBS J. 2006 Jul;273(13):2813-38.
levels of CORTISOL are also associated with
McEwen BS.Association of depression with medical illness: does cortisol play a role?
Biol Psychiatry. 2004 Jan 1;55(1):1-9.
A systematic review of unblended clinical trials involving a total
of 643 cancer patients using MELATONIN found
a reduced incidence of death.
MELATONIN in the treatment of cancer: a systematic review of randomized
controlled trials and meta-analysis.
MELATONIN production has been proposed as a
likely factor in the significantly higher cancer rates in night workers and
breast cancer in women.
has been shown to slow tumor progression in a
variety of cancers - and provide subjective improvement in quality
MELATONIN: Nature's most versatile biological signal?
Gallbladder stones –
in the gallbladder,
MELATONIN converts cholesterol to bile, prevents
oxidative stress and increases mobility of gallstones from the gallbladder.
It also decreases the amount of cholesterol produced in the
gallbladder by regulating the cholesterol that passes through the intestinal
wall. In guinea pigs, MELATONIN
administration restored normal function after induced cholecystitis, by reducing
Oxygen Species and the Hypomotility of the Gall Bladder as Targets for the
Treatment of Gallstones with
MELATONIN: A Review. Daytime
MELATONIN concentration in mammalian bile is
2–3 times higher than daytime (very low) blood levels.
physiological levels of
MELATONIN in the bile of mammals
ALS (Amytrophiic Lateral Sclerosis)
In animal models,
MELATONIN has been shown to ameliorate glutamate-induced neuronal
death, presumed due to its antioxidant effects.
In a clinical safety study involving 31 ALS patients, high-dose rectal
MELATONIN (300 mg/day for 2 years) was shown
to be tolerated well.
oxidative damage in ALS by high-dose enteral
studies in experimental animals show that long-term
MELATONIN supplementation in drinking water reduces body weight and abdominal fat, without changes to diet or
being more active (especially in middle-aged rats)
administration to middle-aged male rats suppresses body weight, intraabdominal
adiposity, and plasma leptin and insulin independent of food intake and total
body fat. A proposed mechanism is that
MELATONIN promotes the recruitment and
activity of brown adipose tissue as well as enhances its activity. , which would
raise the basal metabolic rate by stimulating thermogenesis.
Significance and application of
MELATONIN in the regulation of brown adipose tissue metabolism: relation to
Protection from radiation –
human (2nd Ref) studies have shown
MELATONIN to provide more efficient
protection from ionizing radiation than the commonly used drug amifostine.
Its mechanism is thought due to the scavenging of harmful oxidants (E.g. free radicals), considered to be
responsible for ~70% of ionizing damage to body tissues, especially the hydroxyl
radical that attacks DNA, proteins, and cellular membranes.
MELATONIN has the advantage of being broadly protective, readily available for oral
supplementation, and without significant side effects.
medical studies with adult patients show
beneficial results in the treatment of tinnitus with
MELATONIN is associated with a statistically
significant decrease in tinnitus intensity and improved sleep quality in
patients with chronic tinnitus -
is most effective in:
Those without a history of depression
Those who have not undergone prior tinnitus
Those with more severe and bilateral tinnitus
Those with a history of noise exposure.
Hurtuk A, Dome C, Holloman CH, Wolfe K, Welling DB, Dodson EE, Jacob A (July
2011). "MELATONIN: can it stop the ringing?".
Ann. Otol. Rhinol. Laryngol. 120 (7): 433–40.
The impact of
MELATONIN on sleep was greatest among patients with the worst sleep
quality, but its impact on tinnitus was not associated with the severity of the
Megwalu UC, Finnell JE, Piccirillo JF (February 2006). "The effects of
MELATONIN on tinnitus and sleep".
Otolaryngol Head Neck Surg 134 (2): 210–3.
MELATONIN has been
shown to be useful in the treatment of subjective tinnitus -
with high THI scores and/or difficulty sleeping are most likely to benefit from
SI, Silverstein H, Rowan PT, Olds MJ (March 1998). "Effect of
MELATONIN on tinnitus". Laryngoscope
108 (3): 305–10.
One publication explores the possible mechanisms
MELATONIN works against tinnitus:
Its modulatory effect on central nervous system -
resulting in a protective mechanism against an
exaggerated sympathetic drive (sympathetic nervous system is responsible for
regulating homeostatic conditions in the body);
Its capacity to induce a more steady hemodynamic
condition - through a multifactorial and multi-organ activity, resulting in more
regular blood flow in the inner ear;
A possible action on the skeletal muscle tending
to a reduction of the muscular tone - which
could relieve tinnitus of muscular origin deriving from contraction of tensor
tympani muscles (located in the upper auditory canal) responsible for dampening
Its possible reported anti-depressive effect -
which could indirectly act on tinnitus;
A direct regulation of inner ear immunity -
as proposed in literature when melatonin was
reported to be present in the inner ear.
Retrieved December 6,
2011. Exploring the reasons why MELATONIN can improve tinnitus, August
Studies site a typical
dose for positive effect on tinnitus as 3 mg MELATONIN / day –
usually taken in the evening