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ANDROGENS - TESTOSTERONE - Production in Men

TESTOSTERONE

TESTOSTERONE Production /Secretion in Men

Source of TESTOSTERONE production/secretion :

✔  >95% of circulating TESTOSTERONE secretedby the Lehdig cells of the testes (6-8mg/day) ✔  A small amount produced by adrenal cortex ;

TESTOSTERONE production decreases steadily with age (called Andropause) with a concurrent increase in estrogen levels;

- TESTOSTERONE and estrogen are antagonists - and one particular estrogen, ESTRADIOL, is known to turn on the BCL2 cancer gene, increasing the risk of prostate cancer, when there is an inadequate amount of PROGESTERONE to counteract estrogen'seffect by stimulating the P53 cancer protection gene.

- TESTOSTERONE production decreases 1-2% /yr from age 30 to 70in the U.S

Research by National Institutes of Health

Testes secrete higher levels of TESTOSTERONEin the morning and lower levels in the evening - interestingly this seems to be an intrinsic circadian rhythm, since it is not accompanied by changes in Luteinizing Hormone (LH).

TESTOSTERONE production control

- GnRHfrom hypothalamus stimulates pituitary secretion of Luteinizing Hormone (LH) - which stimulates secretion of TESTOSTERONE from testes;

Hypothalamus

GnRH

Pituitary

LH

Testes

TESTOSTERONE

-By negative feedback, elevated levels of TESTOSTERONE suppress the release of hypothalamic GnRH - ESTRADIOL also suppresses GnRH;

- TESTOSTERONE production is also inhibited by: the inhibition of LH output,by circulating non-SHBG-bound TESTOSTERONE, and especially by DHT (to provide negative feedback control of its own production, which is stimulated by LH); although, even in men, the major hormone involved in LH feedback is ESTRADIOL, not TESTOSTERONE; (SHBG is Sex Hormone Binding Globulin)

TESTOSTERONE is synthesized via two pathways:

-Δ4 pathway - From ANDROSTENEDIONE (via 17-βhydroxysteroid dehydrogenase enzyme) (preferred pathway)

or

-Δ5 pathway - From ANDROSTENEDIOL (itself synthesized from DHEA)

ANDROGENS - Links

Androgens Related Links:

ABOUT ANDROGENS

About Androgens

–“Predominately Male Hormones

SPECIFIC ANDROGENS

ANDROSTENEDIONE

DHEA

TESTOSTERONE

- Production/Secretion in the body

In Men

In Women

- Metabolism

-Functions:

In Men

In Women

- Circulating levels

- Effects / Symptoms of HIGH TESTOSTERONE

In Men

In Women

- Effects / Symptoms of LOW TESTOSTERONE

In Men

In Women

DHT

- Problems Associated with High or Low DHT Levels

(E.g. Acne, PCOS, Hirsutism, BPH, Prostate Cancer)

In Men

In Women

Androgen Dominance (AD)

About Androgen Dominance

-AD-Related Helath Problems
Acne

PCOS

Hirsutism

Congenital Adrenal Hyperplasia (CAH)
Male Pattern Baldness
Female Pattern Baldness
Benign Prostate Hyperplasia (BPH)
Hormones Links

HORMONES

Please link to updated site:

Hormones –“Feel Good, Look Good”

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