Estrogen Transport and Availability
ESTRADIOL (E2) is transported in serum, reversibly bound to sex hormone-binding globulin (SHBG) and, with less affinity, to albumin
The bioavailability of estrogens is modulated by their binding to the sex hormone-binding carrier SHBG
✔ 40% of ESTRADIOL (E2) is bound with high affinity to SHBG
✔ 59% remainder is loosely attached to albumin - both the free and the albumin-bound E2 are bioavailable to various tissues.
✔ ~2% of E2 circulates as a free steroid
Exogenous oral estrogensstimulate increased SHBG production(in the liver cells), whereas androgens suppress SHBG levels(making E2 more bioavailable, since there is less SHBG to bind to).
– Potency of different estrogens is reflected in their ability to bind to SHBG and to stimulate its hepatic synthesis – E.g.Unconjugated equilin (one of the estrogens isolated from horse urine E.g. in Premarin), ESTRONE (E1), and ESTRADIOL (E2) bind with high but different affinities to SHBG. In a comparative study, 0.625 mg conjugated equine estrogens (CEE) increased plasma SHBG by 100% over baseline after 3 months of treatment; 1 mg of oral E2 increased plasma SHBG by 45% and 50 mcg of transdermal E2 increased it by 12%.
Nachtigall LE, Raju U, Banerjee S, Wan L, Levitz M; Serum ESTRADIOL-binding profiles in postmenopausal women undergoing three common estrogen replacement therapies: associations with sex hormone-binding globulin, ESTRADIOL, and estrone levels. Menopause. 2000 Jul-Aug;7(4):243-50.
Attend to Diet, Lifestyle and Emotional State
"The medical kit of the future"
General electrotherapy health benefits. Used systemically and/or locally at specific problem areas of the body, its effective application has many benefits:
|Detoxification||Wellness / Healthy aging||Pain relief|
|Relief from insomnia||Immune system restoral||Anti-Inflammatory|
|Maximizes cellular energy production||Accelerated tissue /bone /scar healing||Stress Reduction|
|Muscle relaxation / rehabilitation||Increased blood oxygen / circulation||+++|
There are several reasonably affordable electrotherapy devices available for personal use. The following electrotherapies are those that have received a significant amount of positive feedback:
* Cranial Electrotherapy Stimulation (CES) applies specific frequency patterns to the head area, with the following benefits:
|Balances brain neuro-transmitters||Relieves pain||Treats depression|
|Substance abuse withdrawal||Relieves insomnia||Relieve stress / anxiety|