Heal Yourself at Home
DIY SOLUTIONS FOR YOUR HEALTH
Hormone menubar

HORMONES

GSE

ESTROGENS:

Estrogen transport and availability

Estrogen Transport and Availability

ESTRADIOL (E2) is transported in serum, reversibly bound to sex hormone-binding globulin (SHBG) and, with less affinity, to albumin

Sex hormone-binding carriers

The bioavailability of estrogens is modulated by their binding to the sex hormone-binding carrier SHBG

✔ 40% of ESTRADIOL (E2) is bound with high affinity to SHBG

✔ 59% remainder is loosely attached to albumin - both the free and the albumin-bound E2 are bioavailable to various tissues.

✔ ~2% of E2 circulates as a free steroid

Exogenous oral estrogensstimulate increased SHBG production(in the liver cells), whereas androgens suppress SHBG levels(making E2 more bioavailable, since there is less SHBG to bind to).

–   Potency of different estrogens is reflected in their ability to bind to SHBG and to stimulate its hepatic synthesis – E.g.Unconjugated equilin (one of the estrogens isolated from horse urine E.g. in Premarin), ESTRONE (E1), and ESTRADIOL (E2) bind with high but different affinities to SHBG. In a comparative study, 0.625 mg conjugated equine estrogens (CEE) increased plasma SHBG by 100% over baseline after 3 months of treatment; 1 mg of oral E2 increased plasma SHBG by 45% and 50 mcg of transdermal E2 increased it by 12%.

Nachtigall LE, Raju U, Banerjee S, Wan L, Levitz M; Serum ESTRADIOL-binding profiles in postmenopausal women undergoing three common estrogen replacement therapies: associations with sex hormone-binding globulin, ESTRADIOL, and estrone levels. Menopause. 2000 Jul-Aug;7(4):243-50.

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Pulsed Electromagnetic Field Therapy (PEMFT)

   Electrotherapy

       "The medical kit of the future"

The Body Electric

General electrotherapy health benefits.   Used systemically and/or locally at specific problem areas of the body, its effective application has many benefits:

Detoxification Wellness / Healthy aging Pain relief 
Relief from insomnia Immune system restoral Anti-Inflammatory
Maximizes cellular energy production Accelerated tissue /bone /scar healing Stress Reduction
Muscle relaxation / rehabilitation Increased blood oxygen / circulation +++

There are several reasonably affordable electrotherapy devices available for personal use. The following electrotherapies are those that have received a significant amount of positive feedback:

*  Cranial Electrotherapy Stimulation (CES) applies specific frequency patterns to the head area, with the following benefits:

Balances brain neuro-transmitters Relieves pain  Treats depression
Substance abuse withdrawal Relieves insomnia Relieve stress / anxiety
 Anti-Inflammatory Fibromyalgia +++