Heal Yourself At Home
DIY SOLUTIONS FOR YOUR HEALTH
~~~ Please read disclaimer at foot of page. NOTHING for sale on this site ~~~
HOME PAGE
WHY THE HEALTH PROBLEMS
HOW TO RESTORE HEALTH
(1) Clean Body's Cleaning Organs
(2) NEWSTARTS
- - "N" = Nutrition
- - "E" = Exercise
- - "W" = Water
- - "S" = Sunlight
- - "T" = Thoughts
- - "A" = Air (Oxygen)
- - "R" = Rest
- - "T" = Trust in God
- - "S" = Sex
(3) Therapies Chart
HEALTH PROBLEMS
SUPPORTING INFORMATION
- The Human Cell 101
- Cellular Respiration
- Acid /Alkaline Balance
- Oxidant /Antioxidant Balance
- Inflammation Information
- Hormones 101
- Neurotransmitters
- The Body Electric
- Bible References to Health
- Toxic Heavy Metals
- Microbes in Health and Disease
The Human Cell 101 - Simple to understand

The Human Cell 101

How do Substances Cross the Cell Membrane

 

Substances can cross the cell or organelle membrane

 by either a passive or active transport mechanism.

 

 

Passive Transport (By Diffusion)

 – Does not require energy

 

      Simple Diffusion (through membrane lipid bi-layer) a substance moves freely across  the membrane lipid bilayer down a concentration gradient (i.e. diffuses from an area of high concentration to an area of low concentration )

 

-       Generally limited to small, non-polar substances - Molecule dissolves in phospholipid bilayer, diffuses across it, then dissolves in the aqueous solution on the other side. E.g. Lipids; steroids; lipid-soluble molecules; Uncharged molecules, such as O2, N2;; Alcohol; Anaesthetic gases (ether); Pesticides; and non-polar solutes, such as CO2, urea.

 

-       Water (polarized) can also diffuse slowly through the lipid by-layer - Water is a special case, passing through the membrane by osmosis.

            

 

 

 

 

      Facilitated Diffusion (carrier or channel mediated) – Substances are transported down an electrical or chemical concentration gradient via a carrier-protein  or ion-channel spanning the membrane. Solutes, such as charged ions in solution (E.g. Na+, K+ and Cl- as solutes) require a carrier or channel to cross the membrane to avoid coming into contact with the water-hating core of the membrane lipid-bilayer. (A carrier or channel is made of protein molecules with a water hating, lipid loving exterior which “happily” spans the membrane, and a water loving center through which water and small water soluble molecules can pass). Some substances, such as glucose, which are too large to pass directly through the membrane, are able to cross when provided a carrier large enough to accommodate them. Some molecules, such as starch and proteins are just simply too large to cross the cell membrane. 

 

 

 

-       A carrier-protein - binds a selective substance on one side of the membrane, and then following a change of shape, the protein releases the substance on the other side of the membrane. Each carrier protein is designed to respond to only one substance. Used to transport small organic molecules (E.g. glucose, sucrose, amino acids) and some inorganic ions (E.g. K+, Na+).

 

 

-       An ion-channel – is a tiny pore generally used to transport only inorganic ions (E.g. K+, Na+ Cl-, Ca2+), but 1000x faster than by carrier protein (Ions move single file at  108 /second). Most ion-channels are selective of the type of ion they allow to pass.

 

 

 

         “Switch-Operated” GATES for Ion-Channels  - most ion-channels contain a “switch-operated” GATE that may be opened or closed, such that a channel only transports when the gate is opened in response to an external chemical, electrical or mechanical stimulus or by conditions within the cell.

 

There are 4 types of gating mechanisms:

 

(1)    Chemically-gated (also called ligand-gated) – Opened/closed by certain binding molecules  (e.g.  neurotransmitters, hormones).

 

 

 

 

 

 

 

 

(2)    Voltage-gated – opened/closed by a change in the cell membrane voltage - K+ and Na+ ion-channels are voltage-gated. The voltage is mainly determined by the balance of K+ and Na+ ions either side of the membrane. The transferral of ions further changes the cell membrane voltage.

 

(3)    Electromagnetic Gate – Opened/closed by specific-frequency electromagnetic signals produced by the body or received from the external environment. 

 

(4)    Mechanical-Gate –  E.g. Opened / closed by sound waves bending the hair cells of the inner ear leading to the creation of nerve impulses, which the brain translates into sound.

 

 

Active Transport (Using a pump)

-  ATP energy is needed to run a “Switch-Operated” Enzyme Pump to transport through a protein channel against a gradient  

 

 

      Direct Active Transport Mechanism - When there is an electrical or chemical gradient  (called an electrochemical gradient) opposing the movement of an ion or molecule across the membrane, a special transport protein pump is needed to convey the ion or molecule.

 

-       Active transport enables the cell to receive essential nutrients from the extracellular fluid - even when the nutrients are more concentrated inside the cell

 

-       Active transport enables the cell to remove waste products from the inside of the cell -  into the extracellular fluid.

 

-       Active transport also supports the vital imbalance of ions - such as K+, Na+, Ca++ and H+ across the membrane.

 

The most important example of direct active transport

 is the sodium/potassium (Na/K) pump

 

The Na/K pump pumps sodium ions (Na+) out of the cell and potassium ions (K+) into the cell, across the membrane against the electrochemical forces, in order to maintain the cell’s “battery” voltage.

 

      Indirect Active Transport Mechanism (E.g. used to transport glucose) - involves using energy to establish a gradient across the cell membrane, and then utilizing that gradient to transport a molecule against its concentration gradient.   The Na+/glucose indirect active transport mechanism, in particular, uses the Na/K pump as the first step, generating a strong Na+ gradient across the cell membrane. Then the glucose/Na+ symport protein uses that Na+ gradient to transport glucose into the cell. (Symport means binding two molecules at a time and using the gradient of one solute’s concentration to force the other molecule against its gradient). 

 

THE HUMAN CELL LINKS

THE HUMAN CELL

Related Links

THE HUMAN CELL 101

Cell Parts  

Cell Membrane“The Cell’s Castle Guard”

-  How do substances cross cell membrane  

CELULAR RESPIRATION

Cellular Respiration

 

 

DISCLAIMER - The information given at this website is for research purposes only. It is not intended to diagnose or cure any mental or physical condition. It is not intended as a substitute for the advice of a licensed professional. In the event that you use this information for your own health, you are prescribing for yourself, which is your constitutional right as a U.S. citizen under Amendment IX of the U.S. Constitution, and for which the author of this information assumes no responsibility. The author of this information is neither a legal counselor nor a health practitioner and makes no claim in this regard. Any references to health benefits of specifically named products on this site are given as this website author's sole opinion and are not approved or supported in any manner by their manufacturers or distributors. COPYRIGHT 2009-2016