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Splenda®(Sucralose) - Toxic organochlorine in a yellow packet

Splenda®(Sucralose) - Toxic organochlorine in a yellow packet

splenda is toxic


Although, using natural sugar to excess has its own set of health problems, natural sugar used in moderation is still a healthier sweetener choice than sucralose

”Made from sugar so it tastes like sugar”

Sucralose is NOT a sugar, despite its sugar-like name and deceptive marketing slogan - it is, in fact, a chlorinated artificial sweetener with detrimental health effects to match aspartame

Sucralose® (trade name Splenda or E.U. additive code E955) is the #1 artificial sweetener in the U.S. - generally used as a sugar substitute

•   Sucralose is a non-nutritive sweetener (NNS) - a white crystalline powder, this supposedly no-calorie sweetener is made from a patented process that begins with sucrose

•  ~ 600 times sweeter than table sugar -~twice as sweet as saccharin and four times sweeter than aspartame

•  Found in > 4,500 food and beverage products - such as baked goods (stable to 450⁰F), non-alcoholic beverages, chewing gum, frozen dairy desserts, fruit juices, and gelatins

•  Found in medications - nearly 10%of all sucralose is sold to drug companies, and many times not listed on label.

•  Splenda® also contains 95% dextrose and maltodextrin as fillers

Sucralose is a synthetic chemical made by a patented process by McNeil Nutritionals that does indeed begin with sugar(sucrose, a disaccharide molecule about 50/50 glucose and fructose). Three hydroxyl (OH) groups are replaced with 3 chlorine molecules, producing a fructose + galactose molecule not seen in nature.

sucrose molecule

Image from Splenda-Clinician's Guide @ www.splenda.com

Here is the “Recipe” for making sucralose:

1.Sucrose is tritylated with trityl chloride in the presence of dimethylformamide and 4-methylmorpholine, and the tritylated sucrose is then acetylated with acetic anhydride.

2.The resulting sucrose molecule TRISPA is chlorinated with hydrogen chlorine in the presence of toluene.

3.The resulting 4-PAS is heated in the presence of methyl isobutyl ketone and acetic acid.

4.The resulting 6-PAS is chlorinated with thionyl chloride in the presence of toluene and benzyltriethylammonium chloride.

5.The resulting TOSPA is treated with methanol in the presence of sodium methoxide to produce sucralose.

Ahhhh. . . just the way grandma used to make it!


The end product is a chlorinated hydrocarbon molecule (a.k.a. an organochlorine or chlorocarbon) - i.e. NOT a sugar molecule.

Sucralose was actually discovered by accident by Tate and Lyle scientists working with researchers at QueenElizabethCollege, trying to create new insecticides.    it was discovered by Leslie Hough and a young Indian chemist, Shashikant Phadnis as the duo was trying to test chlorinated sugars as chemical intermediates.

Phadnis was told to test the powder, but thought that Hough had asked him to taste it. He found the compound to be exceptionally sweet. After this revelation, they worked with Tate & Lyle for a year before settling on the final formula.

In 1980 the rights of sucralose were sold to Johnson and Johnson who then created McNeil Nutritionals to be solely responsible for the marketing of Splenda®.    Later in 2004, McNeil Nutritionals and Tate & Lyle restructured their alliance so that McNeil was responsible for marketing and Tate & Lyle for manufacturing the product.

In 1989, sucralose was approved for use in the United States and Diet R.C. Cola was the first product to contain it

Chlorocarbons - “One lump or two?”

"Sucralose" is a cute short name for:


Chlorine in sucralose is not the same safe form as covalent chloride bonds in food Actually, nature contains NO covalent chloride-to-organic compound bonds.

Examples of other synthetic organochlorines (long known for causing organ, genetic and reproductive damage) include:

•  DDT

•  PCB's

•  Agent orange

J & J maintain that sucralose chlorocarbons are not a problem since sucralose is not absorbed -however, the fact is that the final rule of the FDA was that a significant percentage actually is absorbed in the body.

Organochlorines don't breakdown easily in fatty tissue and can build up over time - in his book “Sweet Deception”, Dr. Joseph Mercola details how researchersfound evidence that Splenda is in fact absorbed by your fat and tends to accumulate in high-fat organ tissues (E.g. your brain) over time.

Researcher / biochemist Dr. James Bowen states that ingested chlorocarbon damage continues with the formation of other toxins:"Any chlorocarbons not directly excreted from the body intact can cause immense damage to the processes of human metabolism and, eventually, our internal organs. The liver is a detoxification organ which deals with ingested poisons. Chlorocarbons damage the hepatocytes, the liver's metabolic cells, and destroy them. In test animals, Splenda®produced swollen livers, as do all chlorocarbon poisons, and also calcified the kidneys of test animals in toxicity studies. The brain and nervous system are highly subject to metabolic toxicities and solvency damage by these chemicals. Their high solvency attacks the human nervous system and many other body systems including genetics and the immune function. Thus, chlorocarbon poisoning can cause cancer, birth defects, and immune system destruction. These are well known effects of Dioxin and PCBs which are known deadly chlorocarbons."

Dr. James Bowen, Article:“The Lethal Science Of Splenda - A Poisonous Chlorocarbon”

Ingested sucralose breaks down into products (1,6 dichloro, 1,6-dideoxyfructose,4-chloro-4-deoxygalactose and potentially highly toxic chlorosugar 6-GC) and has been proven in tests to to be able to have the following adverse effects:

• Liver toxicity, Enlarged livers

• Reduced ability for body to detoxify

• Mutagenic activity

• Binding to DNA in your liver and small intestine

•  Low birth and placental weights, maternal and fetal toxicity (aborted pregnancy)

•   Shrunken thymus glands (up to 40% shrinkage)

•   Enlarged kidneys.

•   Abnormal histopathological changes in spleen and thymus

•   Increased cecal weight

•   Reduced growth rate

•   Adverse changes to GI bacteria

•  Abnormal Pelvic Mineralization / Hyperplasia of the pelvis

•   Decreased red blood cell count

•   Bowel inflammation/Crohn's Disease

•  Migraine triggers

•   Increased glycosylation of hemoglobin (HbA1c) for diabetics

Is sucralose absorbed / metabolized or not?

McNeil claims that Splenda® has zero calories since it is not absorbed by the body - because the body has no enzymes to break down /digest this unnatural, glucose-free molecule, however . . .

The FDA's "Final Rule" reported 11% to 27% of sucralose is absorbed in humans:

•  In animal studies, up to 15% of sucralose is absorbed by the digestive system and stored in the body - The bulk of sucralose ingested does not leave the GI tract and is directly excreted in the feces while 11-27% of it is absorbed. The amount that is absorbed from the GI tract is largely removed from the blood stream by the kidneys and excreted in the urine with 20-30% of the absorbed sucralose being metabolized;

•  Significant percentages of absorbed sucralose is metabolized -“Mice (El46) and rats (El37) were found to metabolize less than 10 percent of the absorbed sucralose, while rabbits(El24) (20 to 30 percent), humans (El38 and E145) (20 to 30 percent), and dogs (El33) (30 to 40 percent) metabolize greater quantities of the absorbed sucralose.”

Michael A. Friedman, Lead Deputy Commissioner for the FDA,Food Additives Permitted for Direct Addition to Food for Human Consumption; SucraloseFederal Register: 21 CFR Part 172, Docket No. 87F-0086, April 3, 1998

-   The Japanese Food Sanitation Council reports that up to 40% of ingested sucralose is absorbed - and can concentrate in the liver, kidney, and GI tract

-   The FDA allowed sucralose absorption / metabolism findings of just ONE 8 man study to be generalized to the entire population - women, children, the elderly, and those with any chronic illness were never examined.

Roberts A, Renwick AG, Sims J, Snodin DJ. Sucralose metabolism and pharmacokinetics in man. Food Chem Toxicol. 2000;38 Suppl 2:S31-41. PubMed

It's been tested, right?

Splenda has NEVER been proven safe for HUMAN consumption!

The marketing pitch for Spenda emphasizes that it has undergone rigorous testing, but fail to mention that nearly all tests were on animals (initial studies showing health detrimental results) and only 2 small (almost laughable) studies lasting less than 4 days on humans prior to FDA approval

Initially, the EU Food Commision, Canadian officials and the U.S. FDA did NOT approve Splenda, based on several serious health problems revealed in animals -so McNeil Nutritionals (Sucralose manufacturer, a subsidiary of Johnson and Johnson) continued their research studies, lowering levels of sucralose administered until favorable results were obtained. Of course, the negative research results were not mentioned.

Splenda®/Sucralose was given the broadest approval ever granted by the FDA for any food additive based on the review of of 108 animal studies and only two human studies lasting only a few days - in 1998 it was approved for use in 15 food and beverage categories, with no requirement for warnings or informational labels on products containing sucralose. A year or so later, the FDA approved sucralose as a general-purpose sweetener.

Of those 2 human studies:

•  They had a total of only 36 subjects -of which only 23 took sucralose!

•  The longest study lasted only 4 days! -and was focussed on sucralose in relation to tooth decay, not human tolerance

The animal studies reviewed revealed several problems:

•  Decreased red blood cells at levels above 1,500 mg/kg/day

•  Increased male infertility by interfering with sperm production and vitality - as well as brain lesions at higher doses

•  Enlarged and calcified kidneys - The FDA ruled that these are findings that are common in aged female rats and are not significant

•   Spontaneous abortions in nearly half the rabbit population given sucralose - compared to zero aborted pregnancies in the control group

•  A 23 percent death rate in rabbits - compared to a 6 percent death rate in the control group

A 2008 Duke University study found that FDA-approved food levels of Splenda:

•   REDUCES the amount of good bacteria in your intestines by 50% -- a disturbing finding since these bacteria help maintain your body's overall balance of friendly versus unfriendly microorganisms and support your general health.

•   INCREASES the pH level in your intestines

•  Can prevent absorption of prescription drugs -by affecting a glycoprotein (P-gp) in your body

Abou-Donia MB, El-Masry EM, Abdel-Rahman AA, McLendon RE, Schiffman SS. Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats. J Toxicol Environ Health A. 2008;71(21):1415-29.  Researchgate

“Increasing evidence suggests that artificial sweeteners do not activate the food reward pathways in the same fashion as natural sweeteners - Lack of caloric contribution generally eliminates the postingestive component. Functional magnetic imaging in normal weight men showed that glucose ingestion resulted in a prolonged signal depression in the hypothalamus. This response was not observed with sucralose ingestion.”

Smeets PAM, de Graaf C, Stafleu A, van Osch MJP, van der Grond J. Functional magnetic resonance imaging of human hypothalamic responses to sweet taste and calories. Am J Clin Nutr. 2005;82:1011-1016. PubMed

Dr. Mercola's website lists many anecdotal reports of harmful side-effects

Dr. Mercola's website

The following are common symptoms - usually noticed within a 24-hour period following consumption of Splenda products:

•  Skin- Redness, itching, swelling, blistering, weeping, crusting, rash, eruptions, or hives (itchy bumps or welts).

•  Lungs- Wheezing, tightness, cough, or shortness of breath.

•  Head- Swelling of the face, eyelids, lips, tongue, or throat; headaches and migraines

•  Nose- Stuffy nose, runny nose, sneezing.

•  Eyes- bloodshot, itchy, swollen, or watery.

•  Stomach- Bloating, gas, pain, nausea, vomiting, diarrhea, or bloody diarrhea.

•  Heart- Palpitations or fluttering.

•  Joints - Joint pains or aches.

•  Neurological- Anxiety, dizziness, spaced-out sensation, depression.

And here's the “Kicker”- Artificial sweeteners may actually promote weight gain

Many people have found that it is easier to lose weight by cutting out sweets altogether instead of just replacing the natural sugar with an artificial one

NNS -May not be such a sweet deal

What are my other sweetener choices?

Natural sweeteners in moderation should be preferred to any artificial sweeteners

Natural Sweeteners

DISCLAIMER: The content on this website is intended for informational, and educational purposes only and not as a substitute for the medical advice, treatment or diagnosis of a licensed health professional. The author of this website is a researcher, not a health professional, and shall in no event be held liable to any party for any direct, indirect, special, incidental, punitive or other damages arising from any use of the content of this website. Any references to health benefits of specifically named products on this site are this website author's sole opinion and are not approved or supported by their manufacturers or distributors.

Attend to Diet, Lifestyle and Emotional State


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