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Neurotransmitters

Neurotransmitters 

About neurotransmitters

 

      Neurotransmitters are chemicals in the body that transmit signals from a nerve cell (neuron) to a target cell across a synapse

 

-       A neurotransmitter is released from a nerve cell  by the arrival of an electrical impulse – the impulse is transferred across the synapse to a target cell when the neurotransmitter binds to a receptor in the membrane on the postsynaptic side of the synapse.

 

-       The receiving target cell can be:

 

         An adjacent nerve cell

         A muscle fiber -  to stimulate movement

         A body organ cell

         Other tissue cell

 

 

      Release of neurotransmitters:

 

-       Usually follows arrival of an action potential at the synapse – whereby the voltage across the cell membrane (membrane potential) of a cell (in this case a presynaptic neuron) rapidly rises and falls.

 

Myelin sheath - consists of Schwann cells that encircle axon like a jelly roll, act as insulators and are separated by gaps of unsheathed axon called Nodes of Ranvier. Instead of a continuous traveling down the axon, the action potential  jumps from node to node (called saltatory conduction), thereby speeding up propagation of impulse.

 

         Follows a graded electrical potential.

 

         Occurs without electrical stimulation as a low level “baseline” release.

 

      Neurotransmitter synthesis – made via just a few biosynthetic steps, from simple precursors, such as amino acids readily available from diet.

 

      Have excitory or inhibitory effect (or both), depending only on the type of receptors they activate – an excitory effect increases the probability that the target cell will fire an action potential.

 

      Types of Neurotransmitters (packaged in neurotransmitter vesicles - membrane enclosed sacks that store and release neurotransmitters into synapse at presynaptic neuron terminal so that they can be detected by receptors on the postsynaptic neuron)

 

 

         Amino acids - E.g. GLUTAMATE (excitatory at >90% of the brain’s synapses), ASPARTATE, GABA (inhibitory at >90% of synapses that do not use GLUTAMATE), glycine

         Monoamines – DOPAMINE, NOREPINEPHRINE

         Peptides – E.g. ß-endorphin (engages with opioid receptors in CNS)

 

Also considered neurotransmitters (shown to be released by presynaptic terminals to produce an action, but are not packaged in vesicles)

 

         Single ions – E.g. zinc

         Gas molecules  E.g. carbon monoxide, NITRIC OXIDE

 

 

      Re-uptake of neurotransmitters - for nerve cells to communicate, neurotransmitters are secreted by one neuron and picked up by receptor proteins on the surface of another neuron. Once the message has been delivered, a neurotransmitter is either destroyed or reabsorbed into the cell that made it and its activity  is over. This process is known as re-uptake.

 

      Most psychoactive drugs exert their effects by altering the actions of some neurotransmitter systems – E.g. Addictive drugs, such as cocaine and amphetamines,  primarily affect the dopamine system. Addictive opiate drugs primarily indirectly regulate dopamine levels.

 

-       Cocaine – blocks reuptake of DOPAMINE back into the presynaptic neuron leaving DOPAMINE in the the synapse for a longer time to bind to receptors on postsynaptic neuron. This elicits a pleasurable emotion, until prolonged exposure causes down-regulation of receptors.

 

-       Prozac  - is a selective SEROTONIN reuptake inhibitor (SSRI), which blocks reuptake of SEROTONIN by the presynaptic cell and potentiates longer effect of SEROTONIN;

 

 

-       Alpha-methyl-p-tyrosine (AMPT) – prevents conversion of tyrosine to the DOPAMINE precursor (L-Dopa);

 

       

Neurotransmitter Related Links

Neurotransmitter

Related Links

ABOUT

About Neurotransmitters

-  Nervous System 101

SPECIFIC

Neurotransmitter Chart

-  NITRIC OXIDE

-  MELATONIN

-  Some Neurotransmitters of Special Mention
DISCLAIMER - The information given at this website is for research purposes only. It is not intended to diagnose or cure any mental or physical condition. It is not intended as a substitute for the advice of a licensed professional. In the event that you use this information for your own health, you are prescribing for yourself, which is your constitutional right as a U.S. citizen under Amendment IX of the U.S. Constitution, and for which the author of this information assumes no responsibility. The author of this information is neither a legal counselor nor a health practitioner and makes no claim in this regard. Any references to health benefits of specifically named products on this site are given as this website author's sole opinion and are not approved or supported in any manner by their manufacturers or distributors. COPYRIGHT 2009-2017