Health Happening
The "No-Brainers" for Physical and Mental Health:
Adequate CoQ10 maintains good health and prevents / reduces the risk for numerous chronic degenerative and metabolic diseases
Supported by a large body of data, the following health problems are associated with CoQ10 deficiency, where CoQ10 supplementation has been found to be beneficial:
CoQ10 has a recognized beneficial role in any neurodegenerative disease characterized by impaired mitochondrial function and/or excessive oxidative damage. Beal MF., 2002; Beal MF.2003; Beal MF. 2004;
Brain cells that suffer continued oxidative stress will eventually die. Oxidative stress causes inflammation, and CoQ10 is a player in reducing the inflammatory marker C-Reactive Protein (CRP) in animals
Wang XL et al, Stocker R. Cosupplementation with vitamin E and coenzyme Q10 reduces circulating markers of inflammation in baboons. Am J Clin Nutr. September 2004;80(3):649-55.
High dose CoQ10 supplementation has been found protective against neuronal toxins in animal models, particularly in Parkinson's and Huntington's diseases, and also ALS. Also, note that sufficient CoQ10 supports a healthy blood flow from the heart, which provides needed nutrients for the brain.
Huntington's Disease. Beal MF, 2001; Ferrante RJ et al, 2002
These results were confirmed by scientists in Germanygiving 360mg doses for 4 weeks to 28 Parkinson's patients.
|
Blood Glucose(mmol/l) |
<=5.5 (n=60) |
5.6 -6.9 (n=63) |
>=7.0 (n=69) |
|
Ubiquinol Ratio (%) Male |
93±6 |
43±25 |
24±11 |
Lim, S. C., et al. Abstract of 2005 American Diabetes Association
Two dramatic case studies published in 1994 confirm CoQ10's role in reducing/removing cancer tumors
A more recent study indicated that breast cancer is associated with a decrease of plasma CoQ10 levels - and the worse the cancer, the greater the decrease in CoQ10. Joliet P et al, 1998
COQ10 improves renal function - Dr. Ram B. Singh of the Heart Research Laboratory and Center for Nutrition in Moradabad, India, reported on a new indication for CoQ10 therapy, in a patient with acute glomerulonephritis, renal failure and high levels of lipid peroxides. He administered 180 mg per day of CoQ10, with a resultant lowering of lipid peroxides and significant improvement in renal function. Singh RB and Singh MM, 1999
In a follow-up study of 11 patients with chronic renal failure (serum creatinine levels were 5 mg/dL or above) who were on intermittent dialysis, Dr. Singh again administered CoQ10 at a dosage of 180 mg per day. After 4 weeks of treatment, the patients experienced significant reductions in serum creatinine and blood urea and significant increases in creatinine clearance and urine output, and fewer subjects required dialysis. Singh, R.B. et al, 2000
CoQ10 is dramatically effective in treating periodontal disease - a common malady of aging. In an early study 8 patients received CoQ10 at 25 mg. twice a day, versus a placebo group. Results showed a reduction in pocket depth with photographic evidence of improved gingival health. Wilkinson, E.G. et al, 1976. In a more recent study, CoQ10 was used topically with significant improvement. Hanioka T et al, 1994
Alleva R et al, Oxidation of LDL and their subfractions: kinetic aspects and CoQ10 content. Molecular Aspects of Medicine, 1997.
Beal, M.F. CoQ10 as a possible treatment for neurodegenerative diseases. Free Radic Res 2002; Kieburtz K (The Huntington Study group), A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 2001;
Beal MF. Coenzyme Q10 as a possible treatment for neurodegenerative diseases. Free Rad Res 2002, 36:455-460;
Beal MF, Shults CW. Effects of Coenzyme Q10 in Huntington's disease and early Parkinson's disease. Biofactors. 2003;18:153-6.
Burke BE et al, Randomized, double-blind, placebo-controlled trial of CoQ10 in isolated systolic hypertension. S Med J Nov. 2001.
Ferrante RJ et al,Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J Neurosci 2002
Greenberg S, Frishman WH. Co-enzyme Q10: a new drug for cardiovascular disease. J Clin Pharmacol 1990;
Hanioka T et al, Effect of topical application of CoQ10 on adult periodontitis. Mol Aspects Med 1994;15(Suppl):s241-s248.
Hodgson, J.M et al, CoQ10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr 2002.
Hojerova J, Coenzyme Q10—its importance, properties and use in nutrition and cosmetics. Ceska Slov Farm 2000;49(3):119-123;
Hoppe U et al, Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors. 1999;9(2-4):371-8; Passi S et al. Lipophilic antioxidants in human sebum and aging. Free Radic Res. April 2002;36(4):471-7
Jolliet, P. et al. Plasma CoQ10 concentrations in breast cancer: prognosis and therapeutic consequences. Int J Clin Pharmacol Ther 1998;36(9):506-509
Langsjoen HA et al, Usefulness of coenzyme Q10 in clinical cardiology: a long-term study. Mol Aspects Med 1994;
Langsjoen PH, Langsjoen AM. Overview of the use of coenzyme Q10 in cardiovascular disease. Biofactors 1999.
Littarru GP, Energy and Defense. C.E.S.I., Rome, 1995;
Lockwood K et al, Partial and complete regression of breast cancer in patients in relation to dosage of CoQ10. Biochem Biophys Res Comm 1994, 199: 3, 1504-1508
Mohr D et al, Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta 1992;
Overvad K et al, Coenzyme Q10 in health and disease. Eur J Clin Nutr 1999;
Rusciani L et al, Low plasma coenzyme Q10 levels as an independent prognostic factor for melanoma progression. J Am Acad Dermatol. Feb 2006;54(2):234-41;
Shultz C.W et al (Parkinson Study Group), Effects of CoQ10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002 Oct.;59(10):1541-50;
Shultz C.W, CoQ10 in neurodegenerative diseases. Curr Med Chem 2003 Oct.;10(19):1917-2
Sinatra ST,The Coenzyme Q10 Phenomenon. Keats Publishing, New Canaan, CT, 1998; Pepping J. Coenyzme Q10. American Journal of Health-System Pharmacy 1999;
Singh, R.B. and Singh, M.M. Effects of CoQ10 in new indications with antioxidant vitamin deficiency. J Nutr Environ Med 1999; 9:223-228
Singh, R.B., Khanna, H.K., and Niaz M.A. Randomized, double-blind placebo-controlled trial of CoQ10 in chronic renal failure: Discovery of a new role. J Nutr Environ Med 2000; 10:281-288
Soja AM, Mortensen SA, Treatment of congestive heart failure with coenzyme Q10 illuminated by meta-analyses of clinical trials. Mol aspects Med 1997;
Wilkinson, E.G. et al, Bioenergetics in clinical medicine VI. Adjunctive treatment of periodontal disease with CoQ10. Res Comm Chem Pathol Pharmacol Aug. 1976; 14(4): 715-719.
