Health Happening
The "No-Brainers" for Physical and Mental Health:
CALCITRIOL (active form of D) is a steroid-like hormone that interacts with its nuclear VDR in target tissues - including the small intestine (to increase calcium absorption), osteoblasts in bone (to increase bone calcium resorption) and in the renal tubular cells in the kidneys (to increase their calcium resorption).
CALCITRIOL induces its own destruction - In order to rein in its own potent calcium metabolism actions, by enhancing expression of an enzyme (25-hydroxyvitamin D-24-hydroxylase; CYP24), which leads to its excretion in bile (as calcitroic acid);
CALCITRIOL regulates cell growth and maturation - by its influence on almost 3,000 genes -since most of the body's tissues and cells possess a VDR and CALCITRIOL
