From the www.lowdosenaltrexone.org website
Bernard Bihari, MD, as well as other physicians and researchers, have described beneficial effects of LDN on a variety of diseases:
Cancers• Bladder Cancer• Breast Cancer • Carcinoid • Colon & Rectal Cancer • Glioblastoma • Liver Cancer • Lung Cancer (Non-Small Cell) • Lymphocytic Leukemia (chronic) • Lymphoma (Hodgkin's and Non-Hodgkin's) • Malignant Melanoma • Multiple Myeloma • Neuroblastoma • Ovarian Cancer • Pancreatic Cancer • Prostate Cancer (untreated) • Renal Cell Carcinoma • Throat Cancer • Uterine Cancer Other Diseases• Common Colds (URI's) • Emphysema (COPD) • HIV/AIDS Syndromes• Chronic Fatigue Syndrome (CFS)• Fibromyalgia |
Autoimmune neuro-degenerative:• Amyotrophic Lateral Sclerosis (ALS/(Lou Gehrig's Disease)• Alzheimer's Disease • Autism Spectrum Disorders (incl. autism disorder, Asperger syndrome) • Multiple Sclerosis (MS) • Parkinson's Disease • Primary Lateral Sclerosis (PLS) • Transverse Myelitis Other Autoimmune Diseases:• Ankylosing Spondylitis • Behcet's Disease • Celiac Disease • CREST syndrome • Crohn's Disease (one of two types of idiopathic inflammatory bowel disease "IBD") • Dermatomyositis • Endometriosis • Hashimoto's Thyroiditis • Irritable Bowel Syndrome (IBS) • Myasthenia Gravis (MG) • Pemphigoid • Psoriasis • Rheumatoid Arthritis • Sarcoidosis • Scleroderma • Sjogren's Syndrome • Stiff Person Syndrome (SPS) • Systemic Lupus (SLE) • Ulcerative Colitis (one of two types of idiopathic IBD) • Wegener's Granulomatosis |
In addition to the above list, LDN Research Trust in the U.K. mentions other health conditions for which LDN may be of benefit:
| Conditions where LDN could be of benefit | |
|---|---|
| Acute disseminated encephalomyelitis | Acute hemorrhagic leukoencephalitis |
| Addison's Disease | Agammaglobulinemia |
| Alopecia areata | Amyotrophic Lateral Sclerosis (ALS) |
| Anti-GBM/TBM Nephritis | Antiphospholipid syndrome |
| Antisynthetase syndrome | Asthma |
| Atopic allergy | Atopic dermatitis |
| Autoimmune aplastic anemia | Autoimmune cardiomyopathy |
| Autoimmune enteropathy | Autoimmune hemolytic anemia |
| Autoimmune hepatitis | Autoimmune inner ear disease |
| Autoimmune lymphoproliferative syndrome | Autoimmune pancreatitis |
| Autoimmune peripheral neuropathy | Autoimmune polyendocrine syndrome |
| Autoimmune PROGESTERONE dermatitis | Autoimmune thrombocytopenic purpura |
| Autoimmune urticaria | Autoimmune uveitis |
| Balo disease/Balo concentric sclerosis | Bechets Syndrome |
| Berger's disease | Bickerstaff's encephalitis |
| Blau syndrome | Bullous pemphigoid |
| Cancers | Castleman's disease |
| Chronic inflammatory demyelinating polyneuropathy | Chronic recurrent multifocal osteomyelitis |
| Churg-Strauss syndrome | Cicatricial pemphigoid |
| Cogan syndrome | Cold agglutinin disease |
| Complement component 2 deficiency | Cranial arteritis |
| Crohns Disease (one of two types of idiopathic inflammatory bowel disease "IBD") |
Cushing's Syndrome |
| Cutaneous leukocytoclastic angiitis | Dego's disease |
| Dercum's disease | Dermatitis herpetiformis |
| Diabetes mellitus type 1 | Diffuse cutaneous systemic sclerosis |
| Discoid lupus erythematosus | Dressler's syndrome |
| Eczema | Enthesitis-related arthritis |
| Eosinophilic fasciitis | Eosinophilic gastroenteritis |
| Epidermolysis bullosa acquisita | Erythema nodosum |
| Essential mixed cryoglobulinemia | Evan's syndrome |
| Fibrodysplasia ossificans progressiva | Fibrosing aveolitis |
| Gastritis | Gastrointestinal pemphigoid |
| Giant cell arteritis | Glomerulonephritis |
| Goodpasture's syndrome | Graves' disease |
| Guillain-Barré syndrome (GBS) | Haemolytic anaemia |
| Hailey -Hailey Disease | Hashimoto's encephalitis |
| Henoch-Schonlein purpura | Herpes gestationis |
| Hypogammaglobulinemia | Idiopathic Inflammatory Demyelinating Diseases |
| Idiopathic pulmonary fibrosis | Idiopathic thrombocytopenic purpura (See Autoimmune thrombocytopenic purpura) |
| IgA nephropathy | Inclusion body myositis |
| Inflammatory demyelinating polyneuopathy | Interstitial cystitis |
| Juvenile idiopathic arthritis | Juvenile rheumatoid arthritis |
| Kawasaki's Disease | Lambert-Eaton myasthenic syndrome |
| Leukocytoclastic vasculitis | Lichen planus |
| Lichen sclerosus | Linear IgA disease (LAD) |
| Lou Gehrig's disease (Also Amyotrophic lateral sclerosis) | Lupoid hepatitis |
| Lupus erythematosus | Majeed syndrome |
| Ménière's disease | Microscopic polyangiitis |
| Miller-Fisher syndrome | Mixed Connective Tissue Disease |
| Morphea | Mucha-Habermann disease |
| Myalgic Encephalomyelitis (ME) | Myositis |
| Neuromyelitis optica (Also Devic's Disease) | Neuromyotonia |
| Occular cicatricial pemphigoid | Opsoclonus myoclonus syndrome |
| Ord thyroiditis | PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcus) |
| Palindromic rheumatism | Paraneoplastic cerebellar degeneration |
| Paroxysmal nocturnal hemoglobinuria (PNH) | Parry Romberg syndrome |
| Pars planitis | Parsonnage-Turner syndrome |
| Pemphigus | Pemphigus vulgaris |
| Perivenous encephalomyelitis | Pernicious anaemia |
| POEMS syndrome | Polyarteritis nodosa |
| Polymyalgia rheumatica | Polymyositis |
| Primary biliary cirrhosis | Primary sclerosing cholangitis |
| Progressive inflammatory neuropathy | Psoriatic arthritis |
| Pure red cell aplasia | Pyoderma gangrenosum |
| Rasmussen's encephalitis | Raynaud phenomenon |
| Reiter's syndrome | Relapsing polychondritis |
| Restless leg syndrome | Retroperitoneal fibrosis |
| Rheumatoid fever | Schmidt syndrome |
| Schnitzler syndrome | Scleritis |
| Spondyloarthropathy | Still's disease |
| Subacute bacterial endocarditis (SBE) | Susac's syndrome |
| Sweet's syndrome | Sydenham chorea |
| Sympathetic ophthalmia | Takayasu's arteritis |
| Temporal arteritis (also known as ""giant cell arteritis"") | Tolosa-Hunt syndrome |
| Undifferentiated connective tissue disease | Undifferentiated spondyloarthropathy |
| Vasculitis | Vitiligo |
Clinical Studies on Safety and Benefits of LDN for Autoimmune Diseases
A couple of examples follow, but a complete list of past and current research is at the lowdosenaltrexone.org website.
- LDN for Multiple Sclerosis. Dr. Maira Gironi, an Italian neurological researcher, treated 40 patients affected with Primary Progressive MS (PPMS) with LDN for six months,concluding that LDN was not only safe and well-tolerated, but halted the progression of the disease in all but one patient. Results published in the journal Multiple Sclerosis .
- LDN for Crohn's Disease. In a pilot study involving 17 Crohn's disease patients, Low-Dose Naltrexone Therapy Improves Active Crohn's Disease, an impressive two-thirds of the patients in her pilot study went into remission, and 89% responded to LDN treatment to some degree. Smith J. et al, Apr. 2007, American Journal of Gastroenterology
