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GSE Peripheral Neuropathy

Peripheral Neuropathy (PN)

About PN

Peripheral neuropathy (PN) results from damage to peripheral nerves that connect the central nervous system (CNS /Brain and Spinal cord) to the rest of the body for two-way communication – peripheral nerves branch out of the spinal cord to all parts of the body, providing a communication link between the brain and the muscles, skin, internal organs, and blood vessels. Damage to this communication network can cause the equivalent of static on a phone line:

PN –Neuron

–   Damage occurs to axons or myelin surrounding peripheral nerves – the axon is the “fiber-optic cable”of a neuron for transmitting messages from neuron body (soma) to make contact with other cells - usually neighboring neurons but sometimes muscle or gland cells.

–   PN damage can affect any or all of the nerves in:

(1) Somatic Nervous System (Used for voluntary control)

✔ Sensory (afferent) nerves from body - receive and transmit sensations from the parts of the body to the brain, E.g. heat, pain or touch.

Damaged sensory nerves may:

Stop relaying signals - resulting in numbness and pain (most often in hands and feet)


Send incorrect signals transmittingsensations of pain, burning or tingling sensations (sometimes described as “pins and needles”)

✔  Motor (efferent) nerves to muscles send messages from the brain to the muscles to control movement.

Damaged motor nerves may:

Impair movement and can lead to muscle weakness / wasting or even paralysis

(2) Autonomic Nervous System (Used for involuntary control)

✔ Sensory and motor nerves - control involuntary functions. E.g. blood pressure, heart rate, digestion and bladder function;

Damaged autonomic nerves may:

Impair any involuntary function - depending on location of damage.

–   PN commonly starts in the longest nerves - i.e. those going to your toes;

–   PN may affect one to several nerves:

✔  Mononeuropathy - 1 nerve;

✔  Multiple mononeuropathy - 2 or more nerves in different areas;

✔  Polyneuropathy - many nerves.

–   If known, PN is classified according to cause or location - for example:

✔ Diabetic neuropathy

✔ Nutritional neuropathy

✔ Radiculopathy - neuropathy resulting from pressure on/injury to a spinal nerve root (Radix) affecting nerve function. Radicular pain and other symptoms (weakness, numbness, pins and needles, lack of muscle control) may manifest as “referred”pain/symptoms in an extremity. E.g. Impingement in the lower back can result in pain/symptoms in the foot. Radiculopathy may be experienced in such as herniated disk, spinal stenosis (narrowing of spinal canal), sciatica and degenerative disk disease;

✔  Entrapment neuropathy occurs when inflammation of connective tissue puts pressure on a nerve passing through it;

✔  Idiopathic neuropathy - when a cause cannot be identified;

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