PCOS is a multi-organ disease which results in small cysts on the outer layer of the ovaries with a concurrent hormonal imbalance - primariy:
- Imbalance in hormones that help regulate the normal development of eggs in the ovaries during each menstrual cycle - In particular, too many androgens (male hormones) are produced. It is not well understood why or how the changes in the hormone levels occur, but these changes can result in:
• Infrequent or no ovulation - making it more difficult to conceive
• Interference with egg release - androgens play a role in blocking egg release
• Higher than normal risk of miscarriage - associated with poorer egg quality;
- Higher INSULIN levels /INSULIN resistance - in a majority of women with PCOS
Normal vs. PCOS ovaries during the monthly cycle?
- With PCOS - alterations in hormonal pathways cause the ovaries to form a number of follicles on the outer layer (cortex) of the ovary. Follicles (egg-containing sacs within the ovaries) normally release one or more eggs during each menstrual cycle - called ovulation. In PCOS, the eggs in the follicles do not mature and are not released from the ovaries. Instead, they can form very small cysts inside the ovary. The ovarian cortex thickens and the egg has difficulty breaking through. No single follicle becomes dominant and ovulation can't occur.
- Normally - each month the ovaries start to ripen a number of follicles, which are actually cysts, tissue sacs filled with fluid and hormones (mostly estrogen). One or two of these follicles grow stronger than the others and produce and mature an egg. When ovulation is triggered by a surge in luteinizing hormone (LH), the egg in the dominant follicle is released into the fallopian tube en route to the uterus, where either it is fertilized within 24 hours, or it regresses. The now empty egg sac becomes a corpus luteum producing large amounts of Progesterone (and smaller amounts of ESTRADIOL) to support the pregnancy. If implantation in the uterus does not occur within 2 weeks the corpus luteum usually regresses (via a process called luteolysis) and the uterine lining is shed, seen as menstrual bleeding.
Unlike larger ovarian cysts (follicles > ~ 2 cms), PCOS cysts do not cause pain and rupture, but because a woman with PCOS doesn't ovulate, hormonal cycles are disturbed causing high levels of estrogens and androgens (E.g.Testosterone and DHEA), yielding symptoms of estrogen and androgen excess.
Minimum criteria for PCOS diagnosis
NIH concensus, from 1990 conference:
- Menstrual irregularity - due to infrequent or no ovulation (i.e. oligo- or anovulation); menstruation may be more or less frequent, and may range from very light to very heavy
- Evidence of hyperandrogenism - E.g. hirsutism, acne, male pattern balding, high serum androgen; PCOS is the cause of > 70% of cases of androgen excess/secondary hirsutism
- Exclusion of other disorders - such as congenital adrenal hyperplasia (CAH), androgen-secreting tumors, or hyperPROLACTINemia
Chronic low-level inflammation (CLII) involved in almost all health problems
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