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GSE Hypothyroidism

What is Hypothyroidism?

Underactivity of thyroid tissue → underproduction of thyroid hormones to maintain body's normal metabolism

Present in Cretinism, Hashimoto's thyroiditis;


Severely stunted physical growth and mental retardation due to untreated thyroid hormone deficiency (congenital hypothyroidism)  in babies or children born to women lacking iodine.

–   Sufficiency of maternal iodine prevents cretinism

–   Babies with congenital hypothyroidism can be treated at birth with supplemental iodine.

Pituitary TSH levels rise.    Due to the negative feedback effect of low T3 and T4 thyroid hormones;


What Causes Hypothyroidism?

Hypothyroidism occurs as a consequence of several possibilities:

–   Insufficient iodine for thyroid hormone production.    Most common worldwide cause;

Why are we Iodine deficient?

–   Thyroiditis.   Inflammation of thyroid cells resulting from a source of damage to thyroid tissue;

✔ Hashimoto's thyroiditis.   Most common problem causing  hypothyroidism in N. America.

✔ Other forms of thyroiditis having hypothyroid phases:

Postpartum (second phase);





Acute infectious.


–   Inborn errors of thyroid hormone synthesis.  Causes congenital hypothyroidism;

–   Pituitary tumors (very rare).   Cause low TSH levels and thereby reduce the production of T3 and T4. This is called secondary hypothyroidism.

Symptoms of Hypothyroidism

May include:

✔ Feeling constantly fatigued

✔ Aching muscles / Vague aches and pains

✔ Cold hands and feet

✔ Weight gain without eating more

✔ Coarse, dry, thinning hair

✔ PMS /Heavy menstrual periods / menstrual cramps

✔ Dry skin

✔ Forgetfulness

✔ Slow heartbeat

✔ Loss of libido

✔ Mental sluggishness/”Fuzzy headed”

✔ Constipation

✔ Depression

✔ Pain in thyroid gland (at front of neck)

✔ Low basal temperature

✔ Infertility /anovulatory cycles / repeated miscarriage

✔ Slowed knee-jerk reflexes

With hypothyroidism, the ability to convert tyrosine to DOPAMINE, NOREPINEPHRINE and EPINEPHRINE is impaired.    This can cause a ripple effect of symptoms, including cognitive dysfunction.

Hypothyroidism can be mistaken for an hormonal imbalance related to an excess of estrogen

Supposed hypothyroidism could actually be Estrogen Dominance

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