Biooxidative Therapy -

- Pathogen Killer / Toxin Eliminator / Anti-cancer

Oxidants are used by immune system (IS) to “Clean House”

Certain activated IS white blood cells (WBCs / leukocytes) produce strong oxidants** to kill pathogens at infection sites, and oxidize (Eliminate) toxins and abnormal cells

For Example:

✔ Phagocytes produce Hydrogen Peroxide H₂O₂ , hydroxyl radical OH^•, and ozone O₃ to kill bacteria and viruses.

**Oxidants are atoms or molecules which take electrons from other molecules–in contrast to reductants which donate electrons to oxidants.

Biooxidative therapy lends the immune system a helping hand

Biooxidative therapyprovides active oxidants to supplement the I.S. attack forces - similarly dealing with microbial infection (i.e. pathogenic bacteria, viruses, fungi, protozoa), Oxidizing toxins and eliminating abnormal cells

The following therapies (at appropriate doses) provide or produce physiological oxidants (mainly reactive oxygen species (ROS):

✔ Chlorine dioxide therapy (CDT using MMS)

✔ Ozone Therapy

✔ Hydrogen peroxide Therapy

✔ Iodine

✔ Aerobic Oxygen Therapy

✔ Hyperbaric oxygen -100% oxygen breathed in a hyperbaric chamber at high pressure

✔ Photodynamic Therapy (PDT) – produces singlet oxygen

✔ Sodium chlorite Therapy

✔ Singlet oxygen Therapy

✔ Others - include zinc peroxide, UV light, benzoyl peroxide, permanganate, various quinones (e.g. Pau D'Arco contains active quinone compounds, benzoquinone, rhodizonic acid),various glyoxals (e.g. glyoxal, methyl glyoxal), anodes, artemisinin, methylene blue, allicin

ROS can damage cell membranes

Phospholipids and lipoproteins provide integrity to cell membranes - without which the cell is unable to survive

Reactive Oxygen Species (ROS), such as Singlet oxygen¹O₂^* and hydroxyl radical (OH^• ) can oxidize unsaturated fatty acids comprising the phospholipid layer of bacterial and body cell membranes - referred to as lipid peroxidation, such oxidation forms hydroperoxides, which can cause irreparable damage to membranes not protected by antioxidant systems. There is also a synergistic effect with cellular-formed H₂O₂.

Effects include:

✔  Increased membrane rigidity

✔ Decreased activity of membrane-bound enzymes (E.g. sodium/potassiumpumps)

✔ Altered activity of membrane receptors

✔ Altered permeability

Reactions involving radicals occur in chain reactions. Note in diagram above that a hydrogen is abstracted from the fatty acid by hydroxyl radical, leaving a carbon-centered radical as part of the fatty acid. That radical then reacts with oxygen to yield the peroxy radical, which can then react with other fatty acids or proteins.

R. Bowen, Free Radicals and Reactive Oxygen, Colorado State University. Link

ROS can also directly attack membrane proteins and induce lipid-lipid, lipid-protein and protein-protein crosslinking - all affecting membrane function.

How do oxidants eliminate pathogens, toxins and abnormal cells?

Oxygenation effect of biooxidative therapy oxidants stimulates immune system (IS) function – allowing the IS to be more effective at doing its job of removing “undesireables”from the body

Anaerobic bacteria, viruses, fungi and damaged /abnormal cells have weak or non-existent antioxidant protection systems in their membranes and thus fall prey to oxidants - and are destroyed or inactivated.

–    Bacteria - singlet oxygen ( ¹O₂^* ) and hydroxyl radical^• (OH^• ) (produced by biooxidative therapies) are known to disrupt the bacterial cell envelope by oxidizing its structural phospholipids and lipoproteins and forming hydroperoxides, which cause irreparable damage to membranes not protected by antioxidant systems. Lipid peroxidation products include alkoxyl and peroxyl radicals, singlet oxygen, ozonides, carbonides, carbonyls, alkanes and alkenes.

–    Fungi (E.g.Candida albicans, athlete's foot, molds, mildews, yeasts)- The mechanism of their destruction is still under discussion, but certain oxidants are purported to inhibit their cell growth at certain stages.

–   Viruses –   oxidants damages the viral capsid and disrupts its reproductive cycle by interrupting the virus-to-cell contact with peroxidation. The weak enzyme coatings on cells which make them vulnerable to invasion by viruses also make them susceptible to oxidation and elimination.

–    Toxins – oxidants oxidize toxic chemicalsfor elimination from the body.

–   Cancer Cells

✔ Oxidants are antineoplastic – i.e. inhibit the growth of rapidly dividing cells

✔ Due to insufficient catalase (CAT) and peroxidase (GPx) antioxidant enzymes in their cell membranes, cancer cells are incapable of effectively inactivating cell-membrane destroying peroxides resulting from biooxidative therapy

✔  The oxygenation effect of biooxidative therapy deters cells from becoming cancerous and boosts immune system to deal with abnormal /cancerous cells

 ✔  Following biooxidative treatment, lactate levels decrease providing evidence that cancer cell metabolism has indeed been inhibited - due to an increased rate of anaerobic glycolysis, malignant cells produce more lactate than normal cells.

Antioxidants control oxidant activity to protect healthy cells

Oxidant activity and presence in the body is controlled by various means:

–    Life-essential metabolic and immune system oxidants are produced only where and when they are needed

–    Oxidantspreferentially neutralize one another - thus keeping their numbers down and preventing tissue damage

–    Antioxidantsprotect healthy cells fromoxidantdamage -as the “burning”/ oxidation process takes place throughout the body, antioxidants prevent over-oxidation, by providing a cooling or regulating system to maintain the metabolic “temperature”at a constant level.

✔ Normal, healthy cells have in-house antioxidant enzyme systems (supported by specific dietary trace minerals) to protect the unsaturated fatty acids in cellular membranes from damaging peroxidation–these enzyme systems: superoxide dismutase (SOD), catalaseS(CAT), reductase and glutathione peroxidase (GPx)) that protect healthy lipid membranes from oxidation, require a sufficiency of their needed support minerals.

✔ Fat-soluble dietary antioxidant vitamins A, D, K, E and CoQ-10 protect fatty acids in the cell membrane

✔ Water-soluble dietary antioxidantvitamin B'sandCprotect against oxidative damage in watery areas - such as blood, lymph and the cell cytosol

Antioxidant “Damage Control”

HOWEVER, To prevent interference with the oxidative nature ofH₂O₂ therapy

you should not take antioxidants within 2 hours of a bio-oxidativetreatment.