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GSE Bio-oxidative Therapies - Oxygenating / Increase Cellular ATP Energy Production

Biooxidative Therapy - Oxygenating

✔ Increase oxygen delivery to cells / Increase ATP energy production

✔ Ensure efficient waste removal from cells

 

The two main uses of Oxygen in the body

1. Efficient cellular energy production "burns” (OXIDIZES) our food-fuel using oxygen - without which the “burn” is incomplete, and instead of forming carbon dioxide, carbon monoxide is formed, which prevents hemoglobin from picking up fresh oxygen. Healthy body cells are "aerobic" and need sufficient oxygen to produce enough energy to function properly.

2. Oxygen is used by the immune system to produce active oxygen molecules which can OXIDIZE and destroy toxins, pathogenic microbes and abnormal (E.g.cancer) cells - which have weak defense systems.

Biooxidative therapy increases oxygen availability to tissues

How do bio-oxidative Therapies increase oxygen levels in tissues?

Biooxidative therapy stimulates Oxygen release from Red blood cells ( RBCs) RBC exposure to Low dose oxidants causes an increase in the their glucose breakdown (glycolysis) rate, which induces an increase in 2,3-DPG enzymes inside RBCs,which catalyze the release of oxygen into surrounding tissues. (Note: Diabetics have depressed 2,3-DPG).

Increased 2,3-DPG (2,3-diphosphoglycerate) causes hemoglobin (Hb), the  main oxygen carrying protein in RBCs, to attach oxygenmore loosely, such that oxyhemoglobin (HbO2) more readily releases it. More oxygen allows cells to generate more energy, often felt as a “rush”or “pick-me-up”.

Hemoglobin in RBCs carries oxygen from the lungs to body tissues preventing the oxygen from reacting with anything until it is delivered. On release, hemoglobin picks up and transports carbon dioxide to the lungs for exhalation.

Germs do not flourish in an oxygenated environmenT

“The microbe is nothing. The terrain is everything”-This quote is ascribed to Claude Bernard (1813-1878), and purportedly quoted by Louis Pasteur (1822-1895) on his deathbed, thereby recanting his still taught germ theory, whichassigns the cause of disease to microbes invadingthe body. In contrast, Bernard and Antoine Bechamp (1816-1908) believed disease was a consequence of an imbalance in the internal terrain of the body. Basically, germs are not the root cause of disease, but rather are a sign of conditions conducive to allowing germs to flourish.

Create an inner “terrain”that is unhospitable to pathogenic microbes - so putting an end to disease-causing oxidative stress.

Oxygen is used up oxidizing toxinS

People are exposed to many unnatural chemicals in our environment, food and water - which overwhelm our undernourished immune system and stay in the body long enough to “gum up the works”. The consequences of toxic-overloadincludes depleted oxygenavailability , leading to clumped blood cells, sluggish circulation, and an internal environment that promotes microbial growth.

–    A downward spiral occurs - as the body ages and fills up with toxins and waste products, their presence reduces oxygen and nutrient supplies which lowers energy production and the ability to oxidize them.

Cells become “sick” in a depleted oxygen environmeNT

It is professionally recognized that many health problems today are caused by a lack of oxygen reaching the body's cells - Nobel Prize winner Dr. Otto Warburg announced this finding back in the 1920's.

–    “Deprive a cell of 35% of its oxygen and it may become cancerous in 48 hours” – Nobel laureate, Dr. Otto Warburg,investigated the metabolism of tumors and the respiration of cells, particularly cancer cells, and was awarded the Nobel prize for physiology in 1931 for his "discovery of the nature and mode of action of the respiratory enzyme in cellular energy production

NobelPrize.org, The Nobel Prize in Physiology or Medicine 1931

Warburg had determined that a cancer cell had partially turned from efficient aerobic respiration to inefficient anaerobic fermentation stating in one of his lectures that “. . . the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar".Warburg observed that mutated cells produce >50% of their energy was generated in the cytosol via inefficient glycolysis ( produces 2 ATP molecules/glucose molecule). Compare this to healthy cells, which produce >90% of their energy in the mitochondria by efficient aerobic respiration (produces~36 ATP molecules / glucose molecule).

PET (Positron Emission Tomography) SCAN

Cancer cells' high glucose consumption allows tumors of a certain size to be detected by a PET scan. This technique utilizes an imaging tool that picks up radio-active glucose injected into a patient. Since cancer cells produce more than half of their energy by glycolysis (break-down of glucose), they consume much more glucose than normal cells, and will therefore accumulate more radio-active material as illustrated in the picture below.

Shown in the left is a Positron Emission Tomography (PET) scan of a 62 year old man with a brain tumour. The irregular bright yellow and orange area in the lower left portion of the brain indicates the location of the tumour, which metabolizes glucose faster than normal cells.

Today, although not accepted as a feature of carcinogenesis, it is accepted that a cancer cell has switched from oxygen respiration to fermentation, and that it is a phenomenon required by rapidly dividing cells (E.g. spermatozoa, proliferating thymocytes, intestinal mucosal cells, renal cells and embrionic stem cells.)

Wojtczak L (1996). The Crabtree effect: a new look at the old problem. Acta Biochim Pol 43,

361–368.

The mechanism for how lack of oxygen is involved in this change is still up for debate. This author holds to the microbial theory of cancer, which explains a cancer cell as one that has been invaded by a “cancer microbe”, which blocks aerobic ATP energy production and eventually alters DNA in the cell nucleus to cause the cell to multiply without control. Certainly, a depleted oxygen environment would beconducive to anaerobic microbial growth and activity.

A significant body of evidence supports the theory that DNA mutations are involved with respiratory damage in cancer cells

“The Warburg effect”

(also called Aerobic Glycolysis)

States that cancer cells rely on glycolysis even when oxygen becomes available. The Warburg Effect is is thought to be due to reprogramming of metabolic genes to allow cancer cells to function more like fetal cells and to enable more glucose to be used for synthesizing macromoles rather than be burned for energy. i.e. glucose is used more for replication than for normal cell metabolism.

“The Crabtree Effect”, attributed to Herbert G. Crabtree in 1926, found that an increase in glucose ▲  decreased oxygen ▼ uptake by tumor cells, which in contrast, induced a slight increase or no effect on respiration of normal cells.

Basicially, once a cell has turned cancerous, it is not lack of oxygen keeping it there, but rather that the cell must adopt a method (i.e. fermentation)that allows increased glucose imports to meet its energy demands for multiplication.

IMPROVES CIRCULATION /INCREASES CELLULAR ENERGY PRODUCTION

Increases circulation / oxygen delivery to body cells by reducing blood clumping- In circulatory disease, a clumping of red blood cells hinders blood flow through the small capillaries, increasing blood viscosity and decreasing oxygen absorption due to reduced surface area. By reducing or eliminating clumping, biooxidative therapy restores their ability to carry oxygen. Oxygenation of the tissues increases as the arterial partial pressure increases and viscosity decreases.

Additionally, biooxidative therapy enhances blood flow by:

✔ Increasing RBC flexibility and plasticity - biooxidative therapy directly changes the electrical charge of the RBC membrane

✔ Inducing production of prostacyclin - a platelet aggregation inhibitor andvasodilator

Increases circulation by oxidizing arterial/venous plaque – biooxidative therapy breaks down plaque inherent in both atherosclerosis and arteriosclerosis(stiffening /hardening joints by fibrosis of the intima and calcification of the tunica media in the vessel wall). Ozone can clear blockages of large and small vessels, allowing for better tissue oxygenation in deficient organs.

–    Shrinks varicose veins and hemorrhoids - veins bring oxygen-depleted blood back to the heart and lungs for re-oxygenation / re-circulation. The returning blood has to travel against gravity in the veins, achieved via muscle contractions and a system of one-way valves. Incompetent valves that allow reversal of flow possibly have a role in varicose veins (which usually occur in the legs), but they are also a result of inelastic veins and poor circulation, allowing vein to become engorged. Biooxidative therapy increases circulation and oxidizes any plaque or fibroses present, allowing varicose veins to shrink to their normal size. Likewise, hemorrhoids succumb to biooxidative therapy

Increases aerobic cellular ATP energy production

–   Increases oxygen delivery to cells

–    Activates the citric acid cycle (aka Krebs or TCA cycle) -by enhancing oxidative decarboxylation of pyruvate, thereby stimulating production of ATP energy molecules. Biooxidative therapy also increases the NADH reducing process and helps to oxidize cytochrome C (“drains”the energy from electrons for ATP energy production by transferriing electrons in the electron transport chain)

Cellular Respiration

References

The Warburg Phenomenon and Other Metabolic Alterations of Cancer Cells

Nutritional Oncology

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