Inflammation caused by oxidan/antioxidant imbalance
Stress, Toxins, Damaged Fats, Microbes
And NOT Enough
Inflammation occurs as a result of Oxidant
major reason damage occurs to body tissue is because too many
highly reactive, oxidant ions/molecules
introduced into or being produced in the body have overwhelmed the body’s
ROS (Reactive Oxygen Species),
(Reactive Nitrogen Species)
and other reactive species are
likely to take part in chemical reactions with your body’s proteins, lipids,
carbohydrates and DNA.
For more detailed information on
Reactive Oxygen Species (ROS), see:
Paradox - Meet Dr.
ROS in the body
come from various sources – some
are listed on this page, but for more detailed information:
Where do ROS in the
body come from?
are produced in the body during
oxidative metabolism produces
metabolism is part of the design to extract energy by
controlled oxidation of substrates, at the same time preventing uncontrolled
good analogy is “To use fire for warmth, but not to get burnt”.
in oxidized Lipids / Trans Fats
In fried, cooked,
cured, aged, or processed foods, chiefly meats, eggs and dairy -
E.g. powdered eggs/milk, scrambled eggs. Dietary oxidized cholesterol is equally
distributed to both HDL and LDL in the body.
University of California Study,
published Feb. 1, 2003.
Cholesterol produced by
the body or consumed in food is oxidized in the body - in its
antioxidant role when it comes into contact
with free radicals. (lipid peroxidation
induced by ROS/RNS seems to be involved not
only in cardiovascular disease, but also in cancer, rheumatoid arthritis, and
other degenerative health problems, including accelerated aging).
are easily oxidized by
In food before consumption -
E.g. during the usual high-temperature commercial process of
extracting vegetable oils from seeds, or in high-temperature processed foods.
E.g. fried foods. Dietary
fats are essential to well-being, but need to be consumed undamaged, in
balance, together with fat-protective
such as vitamins A, D, E. and K;
In the body after consumption – when
antioxidants are deficient; particularly
damaging to cell membranes;
2005 study of 700 nurses - found that
those consuming the most trans fats had a significantly higher risk of
Increase both LDL and Lp(a) -
One study showed significant increases in Lp(a) levels of subjects
consuming diets high in trans fats, but not in those consuming high levels of
saturated fats [J
Lipid Res 1992 Oct;33(10):1493-501]. Nutritionist/author Dr. Mary
Enig maintains that saturated fats actually LOWER Lp(a) levels. (Lp(a) is a
specific type of LDL cholesterol, implicated in, and an accurate marker for CVD)
Lp(a) - The "Repair Man"
Produced by White Blood Cells when body
reacts to an adverse factor
A wound, fever,
nervous imbalance (stress), microbial infection or toxin precipitates an
inflammatory response - in which
radicals, ROS, RNS or other
reactive oxidants are released by
immune system white blood cells (E.g. macrophages).
today’s main oxidation-causing stressor)
Histamine is produced as a result of
Erratic Stress –
Accumulating histamine leads to inflammation and plaque formation. (Bruce H.
Lipton’s histamine theory is that erratic stress induces mast cells on blood
vessel endothelium to emit histamine, which causes cells to multiply).
Having a Type-A personality is linked
to an increased risk of CHD –
characteristics include time urgency and
Trauma / Infective Microbes
Physical damage or presence of
infectious agents, such as bacteria, viruses, protozoa, initiates an
inflammatory process that leads to ROS production by phagocytes -
E.g. infectious bacteria Chlamydia pneumoniae
and the Herpes simplex virus have been
proposed as initial inflammatory infectious agents in atherosclerosis.
are released in the synthesis of prostaglandins and leukotrienes -
local “messenger” molecules released from
unsaturated fatty acids, produced in response to trauma.
Induce inflammatory response leading to damaging
RNS - E.g. cigarette smoking
by-products, exhaust fumes, household chemicals, chlorine,
fluoride, heavy metals,
pesticides/herbicides, GMOs, food additives: E.g. dyes, aspartame, sucralose,
MSG, nitrites (used to cure meat such as bacon, bologna, corned beef, sausages
and hot dogs);
Suwa T, Hogg JC,
Quinlan KB, Ohgami A, Vincent R, van Eeden SF. Particulate air pollution induces
progression of atherosclerosis.
J Am Coll Cardiol.
Pope CA, III,
Burnett RT, Thurston GD, Thun MJ, Calle EE, Krewski D, et al. Cardiovascular
mortality and long-term exposure to particulate air pollution: epidemiological
evidence of general pathophysiological pathways of disease.
Produced by hyperglycemia
(chronically high blood sugar
Hyperglycemia induces an inflammatory
reaction in endothelial cells
(lining interior surface of blood vessels),
which can cause an increase in the production of
ROS (reactive oxidants, including free radicals)
Ceriello P et al, High Glucose Induces Antioxidant Enzymes in Human Endothelial
Cells in Culture, Diabetes Vol 45 April 1996
the formation of oxidized LDL – an important modulating factor in atherosclerosis and