GSE
Bio-oxidative Therapies - Oxygenating / Increase Cellular ATP Energy Production
Oxygenating aspect of biooxidative therapy
• Increase
oxygen
delivery to cells / Increase
ATP
energy production
• Ensure efficient waste removal from
cells
The two main uses of Oxygen in the body
1.
Efficient
cellular energy production "burns"
(OXIDIZES)
our food- fuel using
oxygen. Without which the
"burn" is incomplete, and instead of forming carbon
di mon
oxygen.
Healthy body cells are "aerobic "
and need sufficient oxygen to produce enough energy to
function properly.
2.
Oxygen is used by the immune system to produce
active oxygen molecules. These can
OXIDIZE and destroy toxins, pathogenic microbes
and abnormal (E.g.cancer)cells, which have weak defense systems.
Biooxidative therapy increases oxygen availability
to tissues
Biooxidative therapy stimulates oxygen release from Red
blood cells ( RBCs) - RBC
exposure to
Low dose oxidants oxygen
into surrounding tissues. (Note:
Diabetics have depressed
2,3- DPG ) .
Increased 2,3- DPG
(2,3- diphosphoglycerate) causes hemoglobin (Hb), the main
oxygen carrying protein in RBCs, to attach oxygen more loosely, such
that oxyhemoglobin (HbO2 ) more readily releases it. More
oxygen allows cells to
generate more energy, often felt as a "rush"or "pick- me- up".
Hemoglobin in
RBCs carries oxygen from the lungs to body tissues preventing the
oxygen from reacting with anything until it is delivered. On
release, hemoglobin picks up and transports carbon dioxide to the
lungs for exhalation.
Germs do not flourish in an oxygenated environment
"The microbe is nothing. The terrain is everything".
This quote is ascribed to Claude Bernard (1813- 1878), and
purportedly quoted by Louis Pasteur (1822- 1895) on his deathbed, thereby
recanting his still taught germ theory, which assigns the cause of disease to microbes invading the body. In contrast, Bernard and Antoine Bechamp (1816- 1908) believed
disease was a consequence of an imbalance in the internal terrain of the body.
Basically, germs are not the root cause of disease, but rather are a sign of
conditions conducive to allowing germs to flourish.
Create an inner "terrain" that is
unhospitable to pathogenic microbes. So putting an end
to disease- causing oxidative stress.
Oxygen is used up oxidizing toxins
People are exposed to many unnatural
chemicals in our environment, food and water. These overwhelm our undernourished immune system
and stay in the body long enough to "gum up the works". The consequences of
toxic- overload includes depleted oxygen availability , leading to clumped blood cells, sluggish circulation, and an
internal environment that promotes microbial growth.
- A downward spiral occurs. As the body ages and fills up with toxins and waste
products, their presence reduces oxygen and nutrient supplies which lowers
energy production and the ability to
oxidize
them.
Cells become "sick" in a depleted oxygen environment
It is professionally recognized that many health problems today are
caused by a lack of oxygen reaching the body's cells. Nobel Prize winner Dr. Otto Warburg
announced this finding back in the 1920's.
- "Deprive a cell of 35% of its
oxygen and it may become cancerous in 48 hours" - Nobel laureate, Dr. Otto Warburg,investigated the metabolism of tumors and the respiration of cells,
particularly cancer cells, and was awarded the Nobel prize for physiology in
1931 for his "discovery of the nature and mode of action of the respiratory
enzyme in cellular energy production.
NobelPrize.org,
The Nobel Prize in Physiology or Medicine 1931
Warburg had
determined that a cancer cell had partially turned from efficient
aerobic respiration to inefficient
anaerobic fermentation stating in one of his
lectures that ". . . the prime cause of cancer is the replacement of the
respiration of oxygen in normal body cells by a
fermentation of
sugar ".Warburg observed that mutated cells produce >50% of their energy was
generated in the cytosol via inefficient glycolysis ( produces 2 ATP molecules/glucose molecule). Compare this to healthy cells, which produce >90%
of their energy in the mitochondria by efficient
aerobic respiration (produces~36 ATP molecules /
glucose molecule).
Cancer cells' high
glucose consumption allows
tumors of a certain size to be detected by a PET scan. This technique
utilizes an imaging tool that picks up
radio- active
glucose injected into a patient. Since cancer cells produce
more than half of their energy by glycolysis (break- down of
glucose ), they consume much more
glucose than normal cells, and will therefore
accumulate more radio- active material as illustrated in the picture
below.
Shown left is a Positron Emission Tomography (PET) scan
of a 62 year old man with a brain tumour. The irregular bright
yellow and orange area in the lower left portion of the brain
indicates the location of the tumour, which metabolizes glucose
faster than normal cells.
Today, although not
accepted as a feature of carcinogenesis oxygen respiration to
fermentation, and that it is a phenomenon required by rapidly dividing cells
(E.g. spermatozoa, proliferating thymocytes, intestinal mucosal cells, renal
cells and embrionic stem cells.) (Wojtczak L (1996). The Crabtree effect: a new
look at the old problem. Acta Biochim Pol 43,361- 368)
The mechanism for how lack of
oxygen is involved in this change is still up for debate. This author holds to the
microbial theory of cancer , which explains a
cancer cell as one that has been invaded by a "cancer microbe",
which blocks aerobic
ATP energy production
and eventually alters DNA in the cell nucleus to cause the cell to multiply
without control . Certainly, a depleted
oxygen environment would beconducive to
anaerobic
microbial growth and activity.
A significant body
of evidence supports the theory that DNA mutations are involved with respiratory
damage in cancer cells
(also called Aerobic Glycolysis)
States that cancer cells rely on glycolysis even when
oxygen becomes available. The
Warburg Effect is is thought to be due to reprogramming of metabolic
genes to allow cancer cells to function more like fetal cells and to
enable more
glucose to be used for synthesizing macromoles
rather than be burned for energy. i.e.
glucose is used more for replication than for normal cell
metabolism
"The Crabtree Effect", attributed to Herbert G. Crabtree in 1926,
found that
an increase in glucose
▲
decreased oxygen ▼
uptake by tumor cells
Basicially, once a cell has turned cancerous, it is not lack of
oxygen keeping it there, but rather that the cell must adopt a
method (i.e. fermentation)that allows increased glucose imports to
meet its energy demands for multiplication.
Improves circulation / Increases cellular energy production
Increases
circulation /
oxygen delivery to body cells by reducing blood clumping.
In circulatory disease, a clumping of red blood cells hinders blood
flow through the small capillaries, increasing blood
viscosity and decreasing oxygen absorption due to reduced surface area. By reducing
or eliminating clumping, biooxidative therapy restores their ability to carry
oxygen . Oxygenation of the tissues increases
as the arterial partial pressure increases and viscosity decreases.
Additionally, biooxidative
therapy enhances blood flow by:
• I ncreasing
RBC flexibility and plasticity - biooxidative therapy directly changes
the electrical charge of the RBC membrane
• Inducing production of prostacyclin - a platelet aggregation inhibitor andvasodilator
Increases circulation by oxidizing
arterial/venous plaque. Biooxidative therapy breaks down plaque inherent in both atherosclerosis and
arteriosclerosis(stiffening
/hardening joints by
fibrosis of the intima and calcification of the tunica media in the
vessel wall). Ozone can clear
blockages of large and small vessels, allowing for better tissue oxygenation in deficient
organs.
- Shrinks varicose
veins and hemorrhoids. Veins bring oxygen- depleted blood back
to the heart and lungs for re- oxygenation / re- circulation. The returning blood
has to travel against gravity in the veins, achieved via muscle contractions and
a system of one- way valves. Incompetent valves that allow reversal of flow
possibly have a role in varicose veins (which usually occur in the legs), but they are also a result of inelastic
veins and poor circulation, allowing vein to become engorged.
Biooxidative therapy increases
circulation and oxidizes any plaque or fibroses present, allowing varicose veins
to shrink to their normal size. Likewise,
hemorrhoids succumb to biooxidative therapy
Increases
aerobic cellular ATP
energy production
- Increases
oxygen delivery to cells
- Activates the citric acid cycle
(aka Krebs or TCA cycle). Enhances
oxidative decarboxylation of pyruvate , thereby stimulating production
of ATP energy molecules. Biooxidative therapy also increases the NADH reducing
process and helps to oxidize cytochrome C ("drains"the energy from electrons for ATP energy production by
transferriing electrons in the electron transport chain)
Cellular Respiration
References
The Warburg Phenomenon and Other
Metabolic Alterations of Cancer Cells
Nutritional Oncology
