Treatment for Ischaemic CVD:Â Â Prevent /Modulate Inflammation
Prevent /Modulate Inflammation
General Anti-inflammatory Tactics
Follow the NEWSTARTS Plan:
Nutrition
Exercise
Water
The following link describes tactics to modulate chronic
(long-term) low-level inflammation (CLLI)
How to Treat CHRONIC Low-Level Inflammation (CLLI)
Improve the balance of
antioxidants
vs. oxidants to prevent
radical/oxidant
damage to arteries:
ANTIOXIDANT/ROS BALANCE
Supply sufficient
antioxidants
Especially
A, B6 ,
C , D ,
E and K .
antioxidants
have several roles concerning CVD / High blood pressure:
- CONTROL
oxidants.
W hich would otherwise cause chronic arterial damage
and subsequent inflammatory response /atherosclerosis. Vitamins
A , C, D ,
E,
and Beta-carotene
inhibit lipid peroxidation (as they are Incorporated in endothelial
cells, smooth muscle cells, platelets, immune cells)
- REDUCE inflammatory
cytokines
- REDUCE
calcification in the arteries
- REDUCE platelet aggregation (blood clots):
Here are some study references of
antioxidant roles specifically
related to CVD:
Vitamin C
-
Vitamin C.
Dr. Linus Pauling and his research partner Dr. Mattias Rath determined
that CVD is a symptom of a chronic ascorbate
deficiency, common in most humans.This author surmises that many other symptoms,
including bleeding gums, random nosebleeds, slow healing wounds (E.g. in diabetics),
hemorrhages in disease such as Crohn's and ulcerative colitis, are also consequences
of a low-grade C deficiency, causing weakened
connective tissue, but not full-blown scurvy.
Rath-Pauling Therapy - To strengthen
the vascular wall
-
Vitamin C and
Vitamin E.
Work hand-in-hand together supporting and recycling each other
• Halts LDL oxidation
within the fatty portions of LDL - Vitamin
C stops the free radical damage in the watery medium.
Sato, K., et al., Free radical-mediated chain oxidation of
low density lipoprotein and its synergistic inhibition by vitamin E and vitamin
C. 1990.
Vitamin E
- Vitamin
E deficient arterial walls allow oxidative stress.
Causing many harmful changes in the arteries.
Dr. B. Hennig, University of Kentucky, 1989.
- Vitamin
E protected against the artery damage that leads
to plaque and heart disease. There is a significantly lowered
rate of heart disease and amount of heart disease in any
age group proportionally with the length of time that
vitamin E had been taken -length of time
was actually more important than quantity after a minimum daily dose of 400 IU
1974 epidemiological study conducted by biochemist/author
Dr. R. A. Passwater;
Heart Study of 50- 59 Year Olds. Passwater, Richard A.,
Prevention 28 (5) 111- 115 (May 1976)
Heart Study of 60- 69 Year Olds. Passwater, Richard A.
Prevention 28 (4) 107- 113 (Apr. 1976)
Heart Study of 70- 79 Year Olds. Passwater, Richard A.,
Prevention 28 (2) 61- 68 (Feb. 1976)
-
Vitamin E supplements raise HDL cholesterol.
Several researchers, including Dr. William
Hermann of the Methodist Hospital in Houston and Dr. Staurt Hartz of Tufts University.Hermann,
W., Ann. NY Acad. Sci. 462 1982. A 1987 studyfound that 500 IU /day
of vitamin E for 3 months produces a significantly improved HDL level
Cloarec, M. J., et al., Israel J. Med. Sci. 23(8) 869-72,
Aug. 1987
Effect of Vitamin E on CVD
Details
▼Endothelial cell injury;
▼Inflammatory cytokines and chemokines;
▼LDL oxidation;
▼Macrophage uptake of oxLDL;
Protects against lipid oxidation;
Prevents inflammatory reaction;
▼Adhesion molecule expression;
▼Immune/endothelial cell adhesion
Down-regulates expression of adhesion molecules (ICAM-1 and VCAM-I)
Cominacini L et al. Lacidipine inhibits the activation of the transcription factor NF-kappaB and the expression of adhesion molecules induced by pro-oxidant signals on endothelial cells. J Hypertens. 1997 Dec;15(12 Pt 2):1633-40. PubMed
▼Smooth muscle cell proliferation
Through the inhibition of protein kinase
▼Platelet aggregation
▼TXA2 (thromboxane A2
Reduces the stickiness (clotting) of blood - by inhibiting plasma generation of thrombin (blood clotting enzyme)
Violi F et al. Inhibition of cyclooxygenase-independent platelet aggregation by low vitamin E concentration. Atherosclerosis 82:247-252; 1990 PubMed
▲NO production, ▲Arterial dilation
▲PGI2 (prostacyclin)
Dilates vessels -by enhancing release of prostacyclin, a potent vasodilator and inhibitor of platelet adhesion
Beta-Carotene Beta-carotene
discourages LDL oxidation. Involving
~22,000 male physicians; physicians who took 50mg beta-carotene every other day
had about half as many heart attacks, strokes, cardiac arrests, bypass operations
or angioplasties to remove embolisms.
1990 Harvard Physicians' Health Study
Vitamin D Vitamin D - most people are D deficient;your optimal circulating
CALCIDIOL [25(OH)D]. Level should
be between 50-65 ng/ml, but while treating heart disease, 70-90 ng/ml is recommended.
Test your level using acompany such as Lab Corp.
Vitamin D -The Sunshine Vitamin
-
The further from the equator, the higher risk of high blood pressure -
found a 2007 study, in which researchers theorized that UV exposure leads
to the release of endorphins (brain chemicals linked to pain relief and euphoria)
that lower blood pressure by reducing stressful feelings. Researchers also consider
that decreased vitamin D production
results in increased parathyroid hormone production, serving to increase blood pressure.
Rostand SG, Ultraviolet Light May Contribute to
Geographic and Racial Blood Pressure Differences, Univ. of Alabama, Hypertension.
1997;30:150-156.
-
Another study found that vitamin D actually
serves to lower blood pressure - in that
vitamin D is a negative inhibitor of the renin-angiotensin
system
- Several physiological mechanisms that fight heart disease are triggered by
vitamin D production through sunlight exposure::
• An increase in the body's natural anti-inflammatory
cytokines
• The suppression of vascular calcification
• The inhibition of vascular smooth muscle
growth
British Journal of Nutrition October 2005; 94(4): 483-492
-
D sufficiency produces optimal blood pressure
levels
Lack of Light Causes High Blood Pressure?
-
Vitamin D supplementation lowers calcium deposition
in arteries/lowers blood pressure - Scottish researchers found that calcium
levels in the hair inversely vitamin D was administered, the amount of calcium
in the beard went up and this rise continued as long as
vitamin D was consumed. Almost immediately
after stopping supplementation, however, beard calcium fell to pre-supplement levels.vitamin D or UV-B
treatment has been shown to lower blood pressure, restore
INSULIN sensitivity and lower cholesterol.
Vitamin K (two natural forms are
K1 and K2 )- Vitamin
K1 (found in green vegetables)
is known for its role in ensuring blood is able to form clots when necessary - E.g
to prevent excess bleeding with an injury
- Vitamin
K2 together with
vitamin D
prevent arteriosclerosis (hardening of the medium/large arteries)
due to arterial calcification - calcium buildup in the arteries causes
blood vessels to to lose elasticity rendering them unable to contract and dilate
efficiently. This can lead to a restriction of blood flow delivering nutrients and
oxygen to your organs and tissues. Vitamin K2,
in particular, keeps calcium out of the arteries and other soft tissue and puts
it where it belongs E.g. in teeth and bones.
Health Benefits of K
(See: K2 and D protect Blood Vessels from Calcification)
CoQ10 - acts to scavenge oxidant
species
Coenzyme Q10 - Spark and Dampener
Polyphenols (e.g. in 2 glasses red
wine/day) or flavanols(e.g. in cocoa). In sufficiency reduce
white blood cell adhesion to arterial lining and enable lining cells to make vessel
dilating Nitric oxide (NO).
Selenium.
antioxidants
Glutathione Peroxidase (GPx) and Glutathione (GSH).
- Selenium
found protective against CVD
Oster O, Prellwitz W,(1990), Lancet II 175 (1982), Clin.
Chem. 30:1171 (1984)
- Persons
with low- selenium
diets have two-to-three times greater risk of heart disease than those eating
selenium rich
diets
Omega-3 Quality Antarctic krill oil shown to significantly reduce
total cholesterol, LDL and triglycerides, and increase HDL levels
(1-1.5 g/day krill oil for 90 days + Follow-up of 500mg/day (1 softgel) for
90 days). Recommended preventive maintenance dose is 1000 mg/day.
Antarctic Krill Oil
One study showed that fish consumption reduces
Lp(a) levels. Most likely due to its
omega 3 fatty acids
Arterioscler Thromb Vasc Biol 1999 May;19:1250-6 .
In another study with patients consuming large
quantities of walnuts (contain
omega -3 ALA), Lp(a)
levels were found to decrease an average of over 6% - as well as an
almost equal decrease in LDL cholesterol levels
Ann Intern Med 2000 Apr 4;132(7):538-46 .
Magnesium A
magnesium deficiency is closely associated
with CVD
Magnesium against CVD
Reduce Free Radical
Presence
Minimize dietary
free radical
Intake from: - Refined
carbohydrates (fructose, high fructose syrup, refined sugar and flour).
Prevents hyperglycemia
- Processed
foods/Damaged fats. "Grocery store"vegetable oils,
hydrogenated fats and products containing them usually contain altered, toxic fats,
such as trans fats (tFAs) :
• tFAs
raise LDL and triglycerides and lower HDL cholesterol.
tFAs block the liver's
normal conversion of cholesterol to bile, contributing to higher blood cholesterol
levels The net increase in LDL/HDL ratio with
tFAs
is approximately double that due to
saturated fat ,
and Harvard university researchers determined that those who ate
partially hydrated oils
(which contain
tFAs )
had double the risk of heart attack of those who didn't.
• tFAs
increase
C-reactive protein . Indicative of general inflammation and
an accurate marker for CVD presence and extent;
• tFAs
raise blood levels of lipoprotein(a).
A type of cholesterol used to fix arterial damage.
- Oxidized cholesterol in foods
- Too much
meat. Prevents elevated homocysteine levels
Reduce stress
- Antihistamines.
Histamine accumulates as a result of erratic stress leading to inflammation
and plaque formation.Vitamin C is somewhat
antihistaminic. B6 - Treatment of diabetics with antihistamines or B6 lessened
vascular leakage and curbed retinal degeneration, suggesting an antihistaminic role
for B6.
Avoid environmental toxins
Keep iron levels under control.
Over 50's should have their iron levels
checked since elevated levels can raise cholesterol levels and cause major oxidative
damage in the blood vessels, heart and other organs.
Consume anti-microbial /saturated fats to fight
inflammation-causing microbes. Animal fats, coconut oil
Exercise daily. Reduces
inflammation.
Address emotional issues.
E.g. using
Meridan Tapping Technique
(MTT)
Get plenty of restorative sleep
Avoid smoking or excessive drinking
of alcohol
Reduce glycation and AGES
Minimize sugar/fructose/grains intake
L-Arginine. Inhibits in
vitro non-enzymatic glycation and advanced glycosylated endproduct (AGEs) formation
of human serum albumin.
Anti-inflammatory foods / Ideal Heart-healthy Diet
Great anti-inflammatory foods.
Include
eating fish for omega-3 EPA/DHA , turmeric,
dark chocolate , and red wine (contains the anti-aging polyphenol
resveratrol).
Ideal heart-healthy diet :
• Organic
raw, dairy products from pastured cows. E.g. butter, cream, sour
cream, cheese
• Organic, pastured Eggs.
Lightly cooked with yolks intact, or raw in smoothies
• Avocados
• Raw nuts and seeds in moderation
• Some raw foods / Some cooked foods
• Organic, grass-fed meats.
In moderation (too much meat yields an excess of inflammatory eicosanoids
from omega-6 AA fatty acids, and introduces free radicals by elevating
homocysteine levels)
• Minimal sugar / fructose/grains (even
whole grains). Fructose is found in soda and processed foods. While
you have CVD issues, keep even the fructose from fruit to no more than 15g.
• Plenty of pure water
