FIRST - Prefer 5-HTP supplementation to MELATONIN 5-HTP is higher up the metabolic pathway for MELATONIN, and allows the body the option of converting to MELATONIN on an as needed basis. Also supplies mood beneficial SEROTONIN along the way.
5-HTP ➔ SEROTONIN ➔ MELATONIN.
MELATONIN supplements are readily available over the counter
Supplemental dosage of MELATONIN - Usually in the 1 - 3 mg range and always take at night before bedtime. Taking MELATONIN during the day can reset your body clock, giving you the equivalent of jet lag, which could make you drowsyand increase your risk of accidents.
MELATONIN supplementation will ONLY produce a sedative effect when MELATONIN levels are low
MELATONIN is most effective for treating insomnia in the elderly - as MELATONIN production tends to decline with age.
Unlike sedatives, MELATONIN induces and maintains sleep without suppressing REM (dream) sleep - as suggested by several studies.
MELATONIN is used by travelers to "reset their clocks" and combat jet-lag - restoring restful sleep patterns after flying across one or more time zones.
MELATONIN Safety Studies - studies of MELATONIN's safety are limited; isolated reports have indicated exacerbating depression, fatigue and coronary artery restriction;
High-dose MELATONIN supplementation can disrupt the normal circadian rhythm - In one study, a daily dosage of 8 mg / day for 4 days resulted in significant alterations in hormone secretions;
Certain people should not take MELATONIN:
Women who are pregnant, trying to conceive or nursing - Large doses of MELATONIN may prevent ovulation. The hormone has not been tested for effects on the fetus. MELATONIN can be found in breast milk and the effect of large doses on nursing babies is unknown.
People with immune system disorders - such as severe allergies, autoimmune diseases (like rheumatoid arthritis) or immune-system cancers (like lymphoma). High doses of MELATONIN may stimulate the immune system and may worsen such conditions.
Children and those under 40 - since children naturally produce high levels of MELATONIN, and production declines most rapidly only after age 40.
People with severe mental illness - high daytime doses have worsened the symptoms of some patients.
Those taking medication should consult with a physician - to check interactions
(Edited from Priorities Vol. 7, No. 4, 1995)