MELATONIN stimulates immune system / immunomodulator
Evidence suggests an immuno-enhancing function for MELATONIN - stimulation of natural killer cell activity, cytokine expression and inhibition of immune cell apoptosis have been reported.
- A constant light condition and drug-induced inhibition of MELATONIN synthesis in mice is associated with suppressed humoral an cellular immunological responses
Guerrero JM, Reiter RJ. MELATONIN-immune system relationships. Curr Top Med Chem 2002;2:167-79.
- MELATONIN can interact with cells in lymphoid organs
- There is bidirectional interaction between pineal gland and I.S. Since interleukins and cytokines (interferon gamma) affect MELATONIN synthesis/release
Withyachumnarnkul B, Nonaka KO, Santana C, et al. Interferon-gamma modulates MELATONIN production in rat pineal glands in organ culture. J Interferon Res 1990;10:403-11.
- MELATONIN provides a link between the neuroendocrine and immune systems. May be explored in diseases that present daily rhythmic symptoms, such as rheumatoid arthritis and nocturnal asthma.
- Animal research has shown that inhibition of MELATONIN synthesis weakens cell-mediated immunity (acquired immunity where T lymphocytes have predominant role) and humoral immunity (immune response, mainly against bacterial invasion, mediated by B cells).
MELATONIN increases production of interleukin 2 and 6 (IL-2 and IL-6). MELATONIN receptors are found in lymphatic tissue, which supports the premise that MELATONIN has a direct regulating effect on the immune system. A study evaluating IL-6 during nocturnal sleep,sleep deprivation and different sleep stages concluded that:
“Loss of sleep may serve to decrease nocturnal IL-6 levels, with effects on the integrity of immune system functioning. Alternatively, given the association between sleep stages and IL-6 levels, depressed or aged populations who show increased amounts of REM sleep and a relative loss of slow wave sleep may have elevated nocturnal concentrations of IL-6 with implications for inflammatory disease risk.”
Laura Redwine, Richard L. Hauger, J. Christian Gillin and Michael Irwin. Effects of Sleep and Sleep Deprivation on Interleukin-6, Growth Hormone, Cortisol, and MELATONIN Levels in Humans. Home Archive Oct 2000 85 (10): 3597 JCEM
Chronic low-level inflammation (CLII) involved in almost all health problems
"The medical kit of the future"
General electrotherapy health benefits. Used systemically and/or locally at specific problem areas of the body, its effective application has many benefits:
|Detoxification||Wellness / Healthy aging||Pain relief|
|Relief from insomnia||Immune system restoral||Anti-Inflammatory|
|Maximizes cellular energy production||Accelerated tissue /bone
|Muscle relaxation / rehabilitation||Increased blood oxygen
There are several reasonably affordable electrotherapy devices available for personal use. The following electrotherapies are those that have received a significant amount of positive feedback:
|Pulsed Electromagnetic Field (PEMF) therapy|
|Near Infrared (NIR) class 4 laser therapy|
Cranial Electrotherapy Stimulation (CES) applies specific frequency patterns to the head area, with the following benefits:
|Balances neurotransmitters||Relieves pain||Treats depression|
|Substance abuse withdrawal||Relieves insomnia||Relieve stress / anxiety|