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MELATONIN Health Benefits

MELATONIN stimulates immune system / immunomodulator

Evidence suggests an immuno-enhancing function for MELATONIN - stimulation of natural killer cell activity, cytokine expression and inhibition of immune cell apoptosis have been reported.

-   A constant light condition and drug-induced inhibition of MELATONIN synthesis in mice is associated with suppressed humoral an cellular immunological responses

Guerrero JM, Reiter RJ. MELATONIN-immune system relationships. Curr Top Med Chem 2002;2:167-79.

-    MELATONIN can interact with cells in lymphoid organs

-   There is bidirectional interaction between pineal gland and I.S.    Since interleukins and cytokines (interferon gamma) affect MELATONIN synthesis/release

Withyachumnarnkul B, Nonaka KO, Santana C, et al. Interferon-gamma modulates MELATONIN production in rat pineal glands in organ culture. J Interferon Res 1990;10:403-11.

-    MELATONIN provides a link between the neuroendocrine and immune systems.   May be explored in diseases that present daily rhythmic symptoms, such as rheumatoid arthritis and nocturnal asthma.

-   Animal research has shown that inhibition of MELATONIN synthesis weakens cell-mediated immunity (acquired immunity where T lymphocytes have predominant role) and humoral immunity (immune response, mainly against bacterial invasion, mediated by B cells).

Pandi-Perumal SR, Srinivasan V, Maestroni GJ, Cardinali DP, Poeggeler B, Hardeland R. MELATONIN: Nature's most versatile biological signal? FEBS J. 2006 Jul;273(13):2813-38. PubMed

MELATONIN increases production of interleukin 2 and 6 (IL-2 and IL-6). MELATONIN receptors are found in lymphatic tissue, which supports the premise that MELATONIN has a direct regulating effect on the immune system. A study evaluating IL-6 during nocturnal sleep,sleep deprivation and different sleep stages concluded that:

Loss of sleep may serve to decrease nocturnal IL-6 levels, with effects on the integrity of immune system functioning. Alternatively, given the association between sleep stages and IL-6 levels, depressed or aged populations who show increased amounts of REM sleep and a relative loss of slow wave sleep may have elevated nocturnal concentrations of IL-6 with implications for inflammatory disease risk.”

Laura Redwine, Richard L. Hauger, J. Christian Gillin and Michael Irwin. Effects of Sleep and Sleep Deprivation on Interleukin-6, Growth Hormone, Cortisol, and MELATONIN Levels in Humans. Home Archive Oct 2000 85 (10): 3597 JCEM


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N E W  S T A R T S

C-Reactive Protein - Reliable Inflammation Marker
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Chronic low-level inflammation (CLII) involved in almost all health problems

How to treat CLII

Pulsed Electromagnetic Field Therapy (PEMFT)


       "The medical kit of the future"

The Body Electric

General electrotherapy health benefits.   Used systemically and/or locally at specific problem areas of the body, its effective application has many benefits:

Detoxification Wellness / Healthy aging Pain relief 
Relief from insomnia Immune system restoral Anti-Inflammatory
Maximizes cellular energy production Accelerated tissue /bone
/scar healing
Stress Reduction
Muscle relaxation / rehabilitation Increased blood oxygen
/ circulation

There are several reasonably affordable electrotherapy devices available for personal use. The following electrotherapies are those that have received a significant amount of positive feedback:

Cranial Electrotherapy Stimulation (CES) applies specific frequency patterns to the head area, with the following benefits:

Balances neurotransmitters Relieves pain Treats depression
Substance abuse withdrawal Relieves insomnia Relieve stress / anxiety
Anti-Inflammatory Fibromyalgia +++