Hormone menubar
GSE
MELATONIN Health Benefits
MELATONIN protects the GI tract and pancreas
MELATONIN
is
produced by enterochromaffin cells of the GI mucosa and discharged into the gut
lumen. Where, produced in amounts many times greater than the
pineal gland,
MELATONIN
has several
surprising roles protecting the GI tract from damage and preventing forms of
gastritis.
- Although
MELATONIN produced in the GI tract has a direct effect on GI
tissues, its major influence on GI organs seems to occur indirectly via the
brain-gut axis. Since the GI tract
source of
MELATONIN
also contributes
to circulatory levels. Mechanisms affecting GI organs include peripheral
receptors, sensory afferent (vagal or sympathetic) pathways and the central
nervous system (CNS) acting on these organs via autonomic means.
-
MELATONIN protects gastrointestinal esophageal mucosa
and against various types of injury
Konturek SJ, Zayachkivska O, Havryluk XO, Brzozowski T, Sliwowski Z, Pawlik M,
Konturek PC, Cze?nikiewicz-Guzik M, Gzhegotsky MR, Pawlik WW.Protective
influence of MELATONIN against acute
esophageal lesions involves prostaglandins, nitric oxide and sensory nerves. J
Physiol Pharmacol. 2007 Jun;58(2):361-77.[ PubMed ]
-
MELATONIN seems to control the lower esophageal
sphincter (LES). MELATONIN
has been used successfully as an alternative to
Proton pump inhibitors (PPIs), whose main action is a significant and
long-lasting reduction of gastric acid production. Transient lower esophageal
sphincter relaxation (TLESR) is a major mechanism of reflux in patients with
GERD.
Nitric oxide has an important role in TLESR .
MELATONIN inhibits nitric oxide biosynthesis , providing an
explanation of
the regression of GERD symptoms when using
MELATONIN and other nutrients
- MELATONIN controls gastrointestinal motility, havingan inhibitory action on gastric acid secretion
Jaworek J, Brzozowski T, Konturek SJ.
MELATONIN as an organoprotector in the
stomach and the pancreas. J Pineal Res. 2005;38:73-83. [ PubMed ]
Thor PJ, Krolczyk G, Gil K, Zurowski
D, Nowak L. MELATONIN and serotonin effects
on gastrointestinal motility. J Physiol Pharmacol. 2007;58 Suppl 6:97-103.
[ PubMed ]
-
MELATONIN protects duodenal
(1st part of small intestine)
epithelium against gastric H+
By stimulating
HCO3 - secretion from enterocytes.
Konturek PC, Konturek SJ, Hahn EG.
Duodenal alkaline secretion: its mechanisms and role in mucosal protection
against gastric acid. Dig Liver Dis. 2004;36:505-512. [ PubMed ]
-
Low levels of
MELATONIN can lead to ulcers, gastroesophageal reflux
disease (GERD) and sleep disorders. Commonly, patients with GERD also have a sleep
disorder.
de Souza Pereira R. Regression of an
esophageal ulcer using a dietary supplement containing
MELATONIN . J Pineal Res. 2006;40:355-356.
[ PubMed ]
Pereira Rde S. Regression of
gastroesophageal reflux disease symptoms using dietary supplementation with
MELATONIN , vitamins and aminoacids:
comparison with omeprazole. J Pineal Res. 2006;41:195-200. [ PubMed ]
- Stress / anxiety disorders.
May cause
tryptophan depletion, and as a consequence, low
MELATONIN levels, since
MELATONIN
is a metabolite of this amino acid found in
certain protein foods.
Zimmermann RC, McDougle CJ,
Schumacher M, Olcese J, Mason JW, Heninger GR, Price LH. Effects of acute
tryptophan depletion on nocturnal
MELATONIN secretion in
humans. J Clin Endocrinol Metab. 1993;76:1160-1164.
[ PubMed ]
-
MELATONIN appears to
be implicated in stimulation of pancreatic enzyme secretion after eating.
Mediated by MELATONIN -induced
release of cholecystokinin, acting through entero-gastro-pancreatic reflexes.
Jaworek
J ,
Brzozowski T ,
Konturek SJ .
MELATONIN
as an organoprotector in the stomach and the pancreas .
J Pineal Res.
2005 Mar;38(2):73-83.
-
MELATONIN's GI tract/ pancreas protective/healing
mechanisms.
Increasing
MELATONIN levels should be considered for its
substantial role in prevention of gastric and pancreatic damage and in
accelerating healing of gastric ulcers.
• Damage-protective
mechanisms of pancreas and GI tract. MELATONIN
prevents various forms of gastritis and pancreatitis, via:
• Activation of specific MT2-receptors
• Scavenges
reactive oxygen species (ROS)
- MELATONIN counteracts the increase in the ROS- induced
lipid peroxidation and is partly responsible for preserving the activity of key
anti-oxidizing enzymes such as superoxide dismutase(SOD)
- Accelerates the healing
of chronic gastric ulcerations
• By stimulating the microcirculation
• Interacting withinflammation-controlling prostaglandins, nitric oxide released from vascular
endothelium, and/or sensory nerves and with their neuropeptides.