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Synthetic Sex Steroids

Synthetic Sex Steroids

- “Frankenstein version of natural hormones”

Follow the money!

The drug industry changes a natural hormone molecule to make it patentable – since, bioidentical hormones are not a patentable product, the drug industry chemically alters the natural homrones to make unnatural, but patentable and multi-billion dollar profitable substances E.g. Provera birth control (medroxyPROGESTERONE acetate), to replace bio-identical PROGESTERONE , Premarin for HRT (conjugated estrogens) to replace bio-identical estrogens .

–   If hormone formulation can't be patented, don't expect your doctor to offer bio-identical hormones -pharmaceutical companies can not patent/make money on a hormone naturally produced in the body, explaining why mainstream medicine commonly offers non-bioidentical forms.

–   Sometimes delivery methods can be patented –and companies may then offer bioidentical hormones in such as transdermal skin patches. E.g. Vivelle, Estraderm, and Climara.

A variety of synthetic steroids and sterols have been contrived - Most synthetic hormones are steroids, but some non-steroidal molecules can interact with the steroid receptors because of their similarity in shape. Some examples of synthetic steroid hormones:

✔ Glucocorticoids: prednisone, dexamethasone, triamcinolone

✔ Mineralocorticoid: fludrocortisone

✔ Vitamin D: dihydrotachysterol

✔ Androgens: Oxandrolone, nandrolone (also known as anabolic steroids)

✔ Estrogens: diethylstilbestrol (DES/prevent miscarriage/banned in 1971); ethinylESTRADIOL (used today in almost all oral combination contraceptives);

✔ Progestins: norethindrone (Aygestin/oral contraceptive), medroxyPROGESTERONE acetate (Provera/HRT)

What's the problem with Synthetic hormones?

Some synthetic steroids have a weaker effect on receptors, and some much stronger than the natural steroids whose receptors they activate

Synthetic hormones cause many serious health problems - The 2002 Women's Health Initiative report showed very clearly that synthetic hormones made by pharmaceutical companies caused many serious health problems in women.

Some of the known side effects are:

✔ Increased risk of abortion and congenital abnormalities if taken by pregnant women

✔ Fluid retention

✔ Epilepsy

✔ Migraine

✔ Asthma

✔ Cardiac and renal dysfunction

✔ Depression

✔ Breast tenderness

✔ Nausea

✔ Insomnia

✔ Cancer

✔ Drop in PROGESTERONE levels

The Woman's Health Initiative (WHI) study demonstrated that a combination of Premarin (synthetic estrogen) and Provera produces:

✔ 26% increase in invasive breast cancer;

✔ 29% increase in heart attack risk or CHD death;

✔ 41% increase in stroke risk

✔ 200% increase in risk of blood clots.

These and other synthetic hormones should be banned, but the Wyeth company, for example, has been accustomed to making annual sales of 1 billion dollars on the sale of Premarin and Prempro, and so it doesn't take a rocket scientist to figure why they're still on the market!

Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J; Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA. 2002 Jul 17;288(3):321-33 PubMed

de Lignières B, de Vathaire F, Fournier S, Urbinelli R, Allaert F, Le MG, Kuttenn F. Combined hormone replacement therapy and risk of breast cancer in a French cohort study of 3175 women. Climacteric. 2002 Dec;5(4):332-40. PubMed

Fournier A, Berrino F, Riboli E, Avenel V, Clavel-Chapelon F. Breast cancer risk in relation to different types of hormone replacement therapy in the E3N-EPIC cohort. Int J Cancer. 2005 Apr 10;114(3):448-54. PubMed

Natural /Bio-identical sex hormones are available

The sex hormones most often supplemented are all available in bio-identical form by prescription

Many bioidentical hormones are also available OTC in the U.S. – however, ESTRADIOL (E2) is still not available

(i) Estrogens: ESTRONE (E1) and ESTRIOL(E3);

(ii) PROGESTERONE (as 2% cream)


(iv) DHEA (in low doses) - an adrenal precursor to TESTOSTERONE)

You can legally purchase a prescription drug for your own personal use without a prescription most people are unaware that U.S. Code 21, Section 331 allows you to legally import around a 2-3 month/50 dose supply of any prescription drug for your own personal use, without a prescription. On request, your local U.S. Customs office will send you a free copy of document CF4790 “Know Before You Go” (page 28 and 29)”.

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