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MEALTONIN - The Darkness Hormone - Body's Natural Sleep Aid

MELATONIN “The Darkness Hormone / Natural Sleep aid”

About MELATONIN

MELATONIN is a hormone and a neurotransmitter, produced /secreted by the pineal gland (pea-sized gland located in the center of the brain) during darkness under control of the body's master “Biological Clock” (Body's central circadian pacemaker / Suprachiasmatic nucleus (SCN) in the hypothalamus)

–   The master biological clock (SCN) generates a circadian and annual rhythm of MELATONIN

During , the SCN stimulates the release of Norepinephrine (NE) (from superior cervical ganglion), which activates MELATONIN secretion – MELATONIN production is inhibited by light.

MELATONIN Production

MELATONIN peaks in the middle of the night – and then gradually falls during the second half of the night

MELATONIN activated by , MELATONIN We cannot rely on yesterday's MELATONIN for today and so need a liberal supply each evening

MELATONIN almost negligible in the over 60's

MELATONIN can also be produced directly by the retina, lens, GI tract, skin and other tissues/cells (E.g. bone marrow cells, lymphocytes and epithelial cells are not regulated by light/dark) these cells do not directly release MELATONIN into the blood, but act on local target cells (i.e. by paracrine action).

–    MELATONIN produced by enterochromaffin cells of the GI mucosa represents the most important extra-pineal source of MELATONIN- the GI tract secretes ~400 times the amount of the pineal gland. This MELATONIN enters circulation, where it has an indirect, but profound, protective effect on the GI tract and organs via the brain-gut axis.

MELATONIN affects GI motility, is protective of duodenal epithelium and pancreas, prevents GERD and ulcers, and much more

MELATONIN Production

MELATONIN is both lipid and water soluble – which facilitates passage both in the blood and across cell membranes.After release into circulation, it gains access to various fluids, tissues and cellular compartments (E.g. saliva, urine, cerebrospinal fluid, pre-ovulatory follicle, semen, amniotic fluid, milk). MELATONIN is rapidly metabolized (chiefly in the liver) and is excreted in the urine.

MELATONIN LINKS

MELATONIN

RELATED LINKS

ABOUT

About MELATONIN

- How does it exert its effect?

- Synchronizes body to light/dark cycles

PRODUCTION

- Where produced?

- What affects production?

- Synthesis Pathway

- The Biological Clock

- SAMe –And other methyl donors

- Beta Blockers

- Like leaving the lights on at night

HEALTH BENEFITS

MELATONIN Health Benefits

- MELATONIN induces and improves sleep

- MELATONIN protects GI tract and pancreas

- MELATONIN is anti-proliferative

(i.e. anti-cancer)

- MELATONIN controls depression

- MELATONIN is a powerful antioxidant

- MELATONIN stimulates immune system

- MELATONIN enhances bone mass

BOOST MELATONIN LEVELS

- How to Boost MELATONIN levels

- 5-HTP

- Sunlight –Let there be Light!

SUPPLEMENTATION

Taking a MELATONIN Supplement

- MELATONIN Supplementation Benefits

INSOMNIA

Insomnia

- Different Stages of Sleep