MELATONIN is a hormone and a neurotransmitter, produced /secreted by the pineal gland (pea-sized gland located in the center of the brain) during darkness under control of the body's master “Biological Clock” (Body's central circadian pacemaker / Suprachiasmatic nucleus (SCN) in the hypothalamus)
- The master biological clock (SCN) generates a circadian and annual rhythm of MELATONIN
• During darkness the SCN stimulates the release of Norepinephrine (NE) (from superior cervical ganglion), which activates MELATONIN secretion. MELATONIN production is inhibited by light.
• MELATONIN peaks in the middle of the night. Then gradually falls during the second half of the night
• MELATONIN is not stored in the pineal gland. Activated by darkness, MELATONIN leaves the pineal cells through simple diffusion into the bloodstream. We cannot rely on yesterday's MELATONIN for today and so need a liberal supply each evening
• MELATONIN production peaks at puberty. Production levels rapidly decline until middle-age, continuing into later years.
MELATONIN can also be produced directly by the retina, lens, GI tract, skin and other tissues/cells (E.g. bone marrow cells, lymphocytes and epithelial cells are not regulated by light/dark). These cells do not directly release MELATONIN into the blood, but act on local target cells (i.e. by paracrine action).
- MELATONIN produced by enterochromaffin cells of the GI mucosa represents the most important extra-pineal source of MELATONIN. The GI tract secretes ~400 times the amount of the pineal gland. This MELATONIN enters circulation, where it has an indirect, but profound, protective effect on the GI tract and organs via the brain-gut axis.
• MELATONIN affects GI motility, is protective of duodenal epithelium and pancreas, prevents GERD and ulcers, and much more
MELATONIN is both lipid and water soluble. Facilitates passage both in the blood and across cell membranes.After release into circulation, it gains access to various fluids, tissues and cellular compartments (E.g. saliva, urine, cerebrospinal fluid, pre-ovulatory follicle, semen, amniotic fluid, milk). MELATONIN is rapidly metabolized (chiefly in the liver) and is excreted in the urine.
Attend to Diet, Lifestyle and Emotional State
"The medical kit of the future"
General electrotherapy health benefits. Used systemically and/or locally at specific problem areas of the body, its effective application has many benefits:
|Detoxification||Wellness / Healthy aging||Pain relief|
|Relief from insomnia||Immune system restoral||Anti-Inflammatory|
|Maximizes cellular energy production||Accelerated tissue /bone
|Muscle relaxation / rehabilitation||Increased blood oxygen
There are several reasonably affordable electrotherapy devices available for personal use. The following electrotherapies are those that have received a significant amount of positive feedback:
|Pulsed Electromagnetic Field (PEMF) therapy|
|Near Infrared (NIR) class 4 laser therapy|
Cranial Electrotherapy Stimulation (CES) applies specific frequency patterns to the head area, with the following benefits:
|Balances neurotransmitters||Relieves pain||Treats depression|
|Substance abuse withdrawal||Relieves insomnia||Relieve stress / anxiety|