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MEALTONIN - The Darkness Hormone - Body's Natural Sleep Aid

MELATONIN “The Darkness Hormone / Natural Sleep aid”

About MELATONIN

 

      MELATONIN is a hormone and a neurotransmitter, produced /secreted by the pineal gland (pea-sized gland located in the center of the brain) during darkness under control of the body’s master “Biological Clock” (Body’s central circadian pacemaker / Suprachiasmatic nucleus (SCN) in the hypothalamus)

 

-       The master biological clock (SCN) generates a circadian and annual rhythm of MELATONIN

 

         During  darkness, the SCN stimulates the release of Norepinephrine (NE) (from superior cervical ganglion), which activates MELATONIN secretion – MELATONIN production is inhibited by light.

 

         MELATONIN Production

 

         MELATONIN peaks in the middle of the night – and then gradually falls during the second half of the night

 

         MELATONIN is not stored in the pineal gland – activated by darkness, MELATONIN leaves the pineal cells through simple diffusion into the bloodstream. We cannot rely on yesterday’s MELATONIN for today and so need a liberal supply each evening

 

         MELATONIN production peaks at puberty - then levels rapidly decline until middle-age, continuing the decline until almost negligible in the over 60’s

 

  

      MELATONIN can also be produced directly by the retina, lens, GI tract, skin and other tissues/cells (E.g. bone marrow cells, lymphocytes and epithelial cells are not regulated by light/dark) these cells do not directly release MELATONIN into the blood, but act on local target cells (i.e. by paracrine action).

 

-       MELATONIN produced by enterochromaffin cells of the GI mucosa represents the most important extra-pineal source of MELATONIN  - the GI tract secretes ~400 times the amount of the pineal gland. This MELATONIN enters circulation, where it has an indirect, but profound, protective effect on the GI tract and organs via the brain-gut axis.

 

         MELATONIN affects GI motility, is protective of duodenal epithelium and pancreas, prevents GERD and ulcers, and much more

 

MELATONIN Production

 

      MELATONIN is both lipid and water soluble – which facilitates passage both in the blood and across cell membranes.  After release into circulation, it gains access to various fluids, tissues and cellular compartments (E.g. saliva, urine, cerebrospinal fluid, pre-ovulatory follicle, semen, amniotic fluid, milk). MELATONIN is rapidly metabolized (chiefly in the liver) and is excreted in the urine.

 

 

MELATONIN LINKS

 

MELATONIN

RELATED LINKS

ABOUT

About MELATONIN

How does it exert its effect?

Synchronizes body to light/dark cycles

PRODUCTION

Where produced?

What affects production?

Synthesis Pathway

The Biological Clock

SAMe – And other methyl donors

Beta Blockers

 - Like leaving the lights on at night

HEALTH BENEFITS

MELATONIN Health Benefits

MELATONIN induces and improves sleep

MELATONIN protects GI tract and pancreas

MELATONIN is anti-proliferative

                         (i.e. anti-cancer)

MELATONIN controls depression

MELATONIN is a powerful antioxidant

MELATONIN stimulates immune system

-  MELATONIN enhances bone mass

BOOST MELATONIN LEVELS

How to Boost MELATONIN levels

  5-HTP

Sunlight – Let there be Light!

SUPPLEMENTATION

Taking a MELATONIN Supplement

  MELATONIN Supplementation Benefits

INSOMNIA

Insomnia

-    Different Stages of Sleep