1-2-3 Cancer Treatment Plan
(1) Cancer Treatment CORE - "Cancer NOT Allowed!"
Clodronate - Cancer treatment to prevent bone metasasis
Clodronate - Adjuvant treatment to prevent bone metasases
What is Clodronate and what does it do?
Clodronate is a member of a class of drugs called bisphosphonates, which are
used to treat the bone-thinning disease osteoporosis - It has been around for 20 years, and is a drug
that actually heals, rather than just treats symptoms.
Studies from
Europe show it can:
Reverse bone loss;
Significantly increases lumbar bone density.
Especially when mixed with calcium;
But most importantly:
Clodronate is an effective adjunct to any therapy you are using for the purpose
of preventing bone metastases. A major benefit
for those with breast cancer, where the majority of deaths occur after the
cancer has metastasized to the bones.
It has minimal side
effects and does not kill cancer cells
FDA issued an
approvability letter in 2005 for clodronate
as a breast cancer adjuvant treatment - although, despite its approvability
letter, it is not officially FDA-approved.
Clodronate is not
commercially available in America. Can be
bought online from Canada
Some studies of Clodronate's effectiveness
Clodronate ought to be seriously considered as adjuvant treatment for Stage II
and III breast patients. Given some of the favorable trial results
below, its safe nature and relatively inexpensive cost (under $200 per month
from Canada), in addition to its benefit in reducing bone loss in breast cancer
patients simultaneously receiving anti-estrogen therapy.Newer/future
generation bisphosphonates may have even more potent anti-cancer potential than
Clodronate.
2006 - a large randomized double-blinded placebo controlled multi-center
study of over one
thousand patients over 5 years confirmed reduced skeletal metastasis as well as
possibly favorable survival in breast cancer patients (esp those with Stage II
or III disease rather than Stage I) receiving clodronate as adjuvant over the
initial 2 years.
1993 -Paterson
et al. Noted reduced bone-related morbidity in treated patients and
recommended that Clodronate be further investigated for potentially reducing
bone metastasis as an adjuvant treatment for those who are at risk.
1988 - breast cancer patients with multiple bone metastasis treated with
clodronate experienced fewer fractures and less hypercalcemia, with a higher
survival rate and no side effects. [Biomed. Pharmacother. (France), 42/2
(111-1160];
1987 - two studies showed that oral clodronate successfully reduced a
mean serum calcium concentration in 22 our of 25 patients with various types of
malignant tumors, and that clodronate is a valuable clinical tool in the
management of patients with malignancy-associated hypercalcemia. [Acta. med.
Scand. (Sweden), 221/5 (489-494)];
1985 - clodronate given to patients with episodes of hypercalcemia and
osteolysis due to carcinoma reduced serum calcium in 14 of 17 episodes and bone
resorption in all patients. [Br. J. Cancer (England), 51/5 (665-669)];
1984 - published in both France and the US, this study concluded that
"Clodronate is very effective against osteoclasts," and "Clodronate may be a
useful adjuvant in managing metastatic bone disease." [Presse Med. 13/8,
479-482); New England Journal of Medicine, 308/25 (1499-1501)];
You should not use
clodronate with any of the following conditions:
If you suffer from severe
renal insufficiency (a kidney disorder requiring dialysis);
If you are pregnant or breast-feeding
Hypersensitivity to Clodronate or to other bisphosphonates.
Severe inflammation of the gastrointestinal tract.
More information at:
https://www.ndrugs.com/?s=clodronate
How to take Clodronate
Standard Dosage for treating cancer is 800 mg of clodronate taken orally twice daily.
According to the
Life Extension Foundation, although twice
this dosage has been used safely.
Take on empty stomach, preferably an hour before eating -
otherwise reduces dose into bloodstream.
Breast cancer patients might want to consider a 3
- 5 year regimen on clodronate therapy
Monitor calcium levels and kidney function.
Blood tests to measure serum calcium levels and kidney function should be done
10 days after initiating clodronate therapy and every one to two months
thereafter.
In a small minority of
patients. Clodronate will cause too much calcium to be pulled from the blood
to the bone.
Where to obtain clodronate?
2025 update: Finding where to buy it may be a challenge
Clodronate is available with a doctor's prescription. Brand names include
Bonefos®, Ostac®, Clasteon®
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