P450_SCC (Cytochrome P450 cholesterol side-chain cleavage enzyme)

At the inner membrane, a series of enzymatic reactions occurs:

Enzyme P450SCC Converts:

Cholesterol ➔  PREGNENOLONE (in mitochondria)

Production/Activity of P450_SCC regulated by:

•   LH

P450_SCC inhibitors include:

•    Estrogens

•   Drugs: Aminoglutethimide, 3-methoxybenzidine, cyanoketone, azastine, and danazol.

P450SCC pathway directly affected by:

•   Lead;

•   Vitamin A deficiency;

•   Drugs: Ketoconazole, Mibolerone, Aminoglutethimide, Taxol, Cis-platinum,