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DIY SOLUTIONS FOR YOUR HEALTH

GSE

GSE
Estrogen Production Site Chart

Estrogen Production Site Chart

Who ?

Estrogen Names

Production Sites

(by aromatase enzyme)

Aromatase produced in response to:

Comments

Reproductive

Age Women

ESTRADIOL

(E2)

(17-beta ESTRADIOL)

(circulating hormone)

Ovaries

(granulosa cells)

FSH

ESTRADIOL functions as a circulating hormone (acting on distant target tissues) - Most abundant and potent natural form of estrogen in non-pregnant females during reproductive years.

ANDROSTENEDIONE from ovarian theca cells or adrenal cortex is principal substrate for production of ESTRADIOL in ovarian granulosa cells.

Men

and Women

ESTRONE

(E1)

/ESTRADIOL

(E2)

(Localized metabolism)

Adipose tissue

(mesenchymal cells)

Bone (chondrocytes, osteoblasts)

Skin Fibroblasts

Gluco-corticoids;

Class 1 Cytokines

ESTRONE (E1) is less abundant than E2 and E3 - but the only one of the 3 present in any quantity in and post-menopausal women ;

Adipose and Skin cell aromatization is the major source for circulating ESTRADIOL in men and post-menopausal women adrenal ANDROSTENEDIONE(a derivative of PROGESTERONE )is converted by aromatase to ESTRONE (E1), which is converted to ESTRADIOL by 17βhydroxysteroid dehydrogenase (17β-HSD) activity.

ESTRONE is a reservoir for ESTRADIOL - ESTRONE is converted to a long-lived storage derivative, calledESTRONEsulfate, which can be converted as needed to the more active ESTRADIOL. ESTRONE is weaker than ESTRADIOL.

Adipose tissue is the greatest peripheral source of aromatase in both males and females contributing to ESTRADIOL production.

ESTRONE acts locally at production sites - Circulating estrogensare escapees from local metabolism from such as adipose tissue, brain and bone; Thus low circulating estrogen levels in postmenopausal women and men have little bearing on concentrations in estrogen-producing tissues. E.g. the estrogen responsible for a breast tumor (has up to 10x circulation levels), brain (cognitive) functions, or bone mineralization is that produced locally at those sites.

Brain;

Vascular endothelium;

Aortic smooth muscle

ESTRADIOL (E2)

(Circulating hormone)

Adrenal Cortex

Secretes small amounts of ESTRADIOL;

Adrenal cortex also supplies ANDROSTENEDIONE for conversion to ESTRONE/ESTRADIOL in extragonadal sites.

Men

ESTRADIOL (E2)

ESTRONE (E1)

(Circulating hormone)

Testes

(Leydig cells, Sertoli cells)

FSH

Responsible for at most 15-20% of total circulating ESTRADIOL;

Lehdig cells convert TESTOSTERONE (produced by testes' Sertoli cells) ➔  ESTRADIOL to direct spermagenesis

http://erc.endocrinology-journals.org/cgi/reprint/6/2/131.pdf

Pregnancy

ESTRIOL

(E3)

Placenta

Retinoids

Only produced in significant amounts by the placenta during pregnancy

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