Breast Cancer Menubar
Breast Cancer
Iron and Aluminum Toxicity in Breast Cancer
Iron and aluminum toxicity in breast cancer
Cancers are dependent on Iron
Iron is needed for DNA replication in rapidly dividing
cells. Several studies, (but not all) have shown that free iron
concentrations in ductal breast tissue has a major role in cancer development and
progression to aggressive/deadly cancers.
Wu T et al. Serum iron, copper and zinc concentrations
and the risk of cancer mortality in US adults. Ann Epidemiol 2004; 14: 195-201.
Cade J et al. Case-control study of breast cancer
in southeast England: Nutritional factors. Epidemiol Community Health 1998; 52:
105-110.
Kalinowski DS, Richardson DR. The evolution of iron
chelators for the treatment of iron overload disease and cancer. Pharmacol Rev 2005;
57: 547-583
The transferrin receptor is over-expressed on the surface
of cancer cells. Transferrin is a serum iron transport which
delivers Fe (III) into cells. Since most cancer drugs target rapidly dividing cells,
transferrin has even been considered as a delivery mechanism for cancer drugs.
Breast cancer nipple fluid found to have~2X aluminum and 5X ferritin
levels than normal
Department of Biomolecular Sciences, Urbino Italy
found that in addition to almost twice as much aluminum, that women with breast
cancer had 5X higher levels of ferritin, an iron transport protein (also
confirmed in other studies).
Ductal nipple fluid.
Extracted via a breast pump in pre- and post-menopausal women
is examined to measure levels of such as iron, ferritin (an iron-binding protein),
CRP (a measure of breast inflammation) and aluminum.
Mannello F, et al. Analysis of aluminum content and iron
homeostasis in nipple aspirate fluids from healthy women and breast cancer-affected
patients. J Appl Toxicol 2011; Feb 21;
MMannello et al and Shpyleva SI et al. Role of ferritin
alterations in human breast cancer cells. Breast Cancer Res Treat 2011; 126: 63-71
In previous studies, iron intake did not necessarily
correlate with breast cancer risk, however, more critical was the release of iron
from its protective proteins. This explains why some
studies found no link between iron intake in the diet and breast cancer incidence.
Lithgow D et al. C-reactive protein in nipple aspirate
fluid: relation to women's health factors. Nurs Res 2006; 65: 418-425.
Kabat GC et al. Dietary iron and heme iron intake
and risk of breast cancer: a prospective cohort study. Cancer Epidemiol Biomarkers
Prev 2007; 16:1306-1308.
Free Bound Free iron levels in breast
ductal tissue can become dangerously high and over time induce malignant tumor formation.
90% of iron absorbed from your diet is normally
bound to protective proteins, such as ferritin and transferrin.
Studies have shown that certain activities can cause too much of the iron to be
released into surrounding tissues, and if this iron exists as free iron, it can
trigger inflammation,lipid peroxidation, and free radical generation. Bound iron
is relatively harmless.
What can cause iron to be displaced and released from
these protective proteins as free iron ?
Excessive alcohol
intake. Women who drink greater than 20 grams of alcohol a day
significantly increase the free iron in their breast tissue and have a higher incidence
of invasive breast cancer—the most deadly form.
Lee DH et al. Dietary iron intake and breast cancer: The
Iowa Women's Health Study. Proc Am Assoc Cancer Res 2004; 45: A2319.
Excessive
estrogen.
Can displace iron from its protective proteins, thus increasing free
iron levels and associated breast cancer risk. This helps explain the link between
high estrogen levels and breast cancer.
Wyllie S, Liehr JG. Release of iron from ferritin storage
by redox cycling of stilbene and steroid estrogen metabolites: a mechanism of induction
of free radical damage by estrogen. Arch Biochem Biophys 1997; 346: 180-186
Aluminum can
displace iron from its protective proteins. BTW,
aluminum toxicity is strongly implicated in autism, ADHD and Alzheimer's.
Aluminum and alcohol can raise the level of harmful
free iron (by displacing the iron from its protective proteins).
Lee DH et al. Dietary iron intake and breast cancer:
The Iowa Women's Health Study. Proc Am Assoc Cancer Res 2004; 45: A2319.
Where is the aluminum coming from?
Vaccine adjuvants - Many
inactivated vaccines contain aluminum salts to boost their immune reaction to the
antigen (your body responds to the antigen by making antibodies against the injected
virus, and boosting immune response allows vaccine manufacturer to use less of the
expensive antigen)
Flarend et al. In vivo absorption of aluminum-containing
vaccine adjuvants using Al-26. Vaccine 1997 15, 1314-1318.
The anthrax
vaccine, hepatitis vaccine and tetanus vaccine contain particularly high amounts
of aluminum. Many vaccines contain aluminum, including:
Hepatitis A and B
DtaP (diphtheria, tetanus, pertussis)
Hib vaccine
Pneumococcal vaccine
Gardasil (HPV vaccine)
The FDA sets the guidelines for what
and how much aluminum is allowed in vaccines. The maximum amount
of allowable elemental aluminum is 850 mcg per vaccine, although, oddly, there is
no distinction made between a small infant or an adult. Dr. David Ayoub, a radiologist,
physician, and specialist on the additives and preservatives used in vaccines, discovered
that the FDA 850 mcg limitation is based on the effectiveness of the adjuvant role
of aluminum and has nothing to do with limitations based on safety! The average
aluminum content per vaccine ranges between 200 to 400 mcg. Some contain less. Many
children end up receiving multiple vaccines at a time and children today are receiving
17 shots that contain aluminum, compared to four vaccines in the 1970s - mid-80s.By the age of
6, American children have been exposed to multiple injected doses of aluminum-containing
vaccines - A recent study by Lucija Tomljenovik and Chris Shaw found that
a newborn receives a dose of aluminum that exceeds FDA safety limits (5mg/kg/day)
for injected aluminum by 20-fold, and at 6 months of age a dose that was 50-fold
higher than FDA safety limits.
Tomljenovic L and Shaw C. 2011 in press.
Underarm antiperspirants?
Aluminum bake ware?
Treatment and prevention of aluminum toxicity
Avoid/minimize exposures:
Avoid cooking with aluminum utensils/pans
Don't
store food in contact with aluminum
Use
aluminum-free baking soda, deodorant, toothpaste
Avoid
aluminum-containing vaccines, or separate multiple aluminum- containing vaccines
by 2-4 weeks
Avoid
drinks in aluminum pouches/cans - especially if they contain citrates/ascorbates
which enhance aluminum absorption
Take
vitamin C and fruit juices on an empty stomach
Minimize
exposure to calcium carbonate-containing medicines -many are contaminated with aluminum
Other tactics to combat aluminum poisoning:
Maintain normal
serum Vitamin D levels Maintain MELATONIN levels .
This powerful antioxidant produced by the body at night in the
dark, is particularly depleted by aluminum exposure;
MELATONIN - The Sleep Hormone
Curcumin Include Foods / Supplement
that drive the methylation process (methionine cycle).
i.e., B6, B12, folic acid, folinic acid, etc Cilantro.
Natural chelation Chelation
Oral calcium
disodium EDTA. Pulls lead and aluminum, but is also contaminated
with aluminum, as are many calcium-containing products. Intravenous EDTA can be
administered by healthcare professional.
Rectal-use Detoxamin.
Has low absorption of the aluminum contaminant, that requires iron-transport system
found mostly in small bowel as opposed to the rectum.
Deferoxamine
(DFO) is a potent chelator for iron and aluminum poisoning.
However, it has potential serious side effects and can only be administered by a
physician.
Iron toxicity involved in other diseases
With the ability of aluminum to displace iron from its protective proteins.
We may not only see a dramatic increase in breast cancer, but also other iron-related
diseases, such as liver degeneration, neurodegenerative disease, diabetes, heart
failure and atherosclerosis. No one is addressing this very real danger.
References
NEW Studies Reveal Alarming Hidden Cause of Breast Cancer, Russell L. Blaylock,
MD, CCN
