Dutkiewicz, S. (1996). Usefulness of Cernilton in the treatment of benign
prostatic hyperplasia. International
Urology and Nephrology, 28(1),
49-53. doi:10.1007/bf02550137
Omega-3 fatty acids EPA and DHA. High levels of these active O3 fats
helped inhibit growth of PC cellsOIly fish,
The more fish rich in omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic
acid (DHA) that you eat, the less your risk will be for developing prostate cancer.
In both population and animal studies, there were high levels of EPA and DHA in
red blood cells and helped inhibit growth of prostate cancer cells.[11]
In both population and clinical studies, researchers have found that supplementing
vitamin E can help significantly reduce the risk of prostate cancer. However, it'scrucial to try and consume natural forms of vitamin E, versus synthetic ones. This
is because the synthetic version may keep the natural vitamin E from effectively
entering cell membranes.[8,13]
In a 10-year cancer prevention trial, researchers found that selenium helped reduce
the incidence of prostate, colon, and lung cancer. Although the study was conducted
in 1962, it was extremely exciting because it showed that certain cancers could
potentially be prevented by a simple supplement.[14]
Lycopene is the naturally occurring compound found in foods like tomatoes that gives
them their red coloring. Its popularity as an anticancer treatment happened after
Harvard researchers found that, compared to other carotenes, lycopene was the only
that clearly protected against prostate cancer.[15]
The scientific evidence for vitamin D'seffectiveness against prostate cancer remains
limited and inconsistent. However, a 2000 study found that men who had a vitamin
D deficiency were twice as likely to develop more aggressive forms of prostate cancer.[16]
Especially effective
with prostate problems, including prostate cancer - Works better than MMS1
More frequent ejaculation decreases PC risk - it is theorized
that ejaculation drains the prostate
-
Vasectomies cause prostate not to drain during ejaculation - offering an explanation
for the high rate of PC associated with a vasectomy.
♦
Consume 100 mg ginger extract /kg body weight - equivalent to about 550 mg for a
man weighing 150 pounds. Researchers estimated that 100 grams (~4oz) fresh ginger
eaten daily will offer the same results.
Vitamins
Vitamin K2 (Not K1)
Vitamin K2
K2 - A study published by the European Prospective Investigation into Cancer
and Nutrition (EPIC) has revealed that increased intake of vitamin K2 may reduce
the risk of prostate cancer by 35%. The authors point out that the benefits of K2
were most pronounced for advanced prostate cancer, and, importantly, that vitamin
K1 did not offer any prostate benefits. The findings were based on data from more
than 11,000 men taking part in the EPIC Heidelberg cohort.
http://www.ajcn.org/content/87/4/985.abstract
Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort
of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)1,2,3
Katharina Nimptsch, Sabine Rohrmann and Jakob Linseisen
1 From the Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg,
Germany
Background:Anticarcinogenic activities of vitamin K have been observed in various
cancer cell lines, including prostate cancer cells. Epidemiologic studies linking
dietary intake of vitamin K with the development of prostate cancer have not yet
been conducted.
Objective:We evaluated the association between dietary intake of phylloquinone
(vitamin K1) and menaquinones (vitamin K2) and total and advanced prostate cancer
in the Heidelberg cohort of the European Prospective Investigation into Cancer and
Nutrition.
Design:At baseline, habitual dietary intake was assessed by means of a food-frequency
questionnaire. Dietary intake of phylloquinone and menaquinones (MK-4-14) was estimated
by using previously published HPLC-based food-content data. Multivariate-adjusted
relative risks of total and advanced prostate cancer in relation to intakes of phylloquinone
and menaquinones were calculated in 11 319 men by means of Cox proportional hazards
regression.
Results: During a mean follow-up time of 8.6 y, 268 incident cases of prostate
cancer, including 113 advanced cases, were identified. We observed a nonsignificant
inverse association between total prostate cancer and total menaquinone intake [multivariate
relative risk (highest compared with lowest quartile): 0.65; 95% CI: 0.39, 1.06].
The association was stronger for advanced prostate cancer (0.37; 0.16, 0.88; P for
trend = 0.03). Menaquinones from dairy products had a stronger inverse association
with advanced prostate cancer than did menaquinones from meat. Phylloquinone intake
was unrelated to prostate cancer incidence (1.02; 0.70, 1.48).
Conclusions: Our results suggest an inverse association between the intake of
menaquinones, but not that of phylloquinone, and prostate cancer. Further studies
of dietary vitamin K and prostate cancer are warranted.
Vitamin K2 is found in:
•
Fermented cod liver oil
Zinc -The man's mineral!
♦ The prostate needs 10 times more zinc than any other
organ in the body.
• It
is vital for preventing prostate problems, and for BPH sufferers.(11)
Unfortunately, 90% of us consume diets deficient in zinc (12), because most of the
zinc in our food is lost in processing, or never exists in a substantial amount
due to our nutrient-poor soils.(13)
Irving Bush and associates at Chicago's Cook County Hospital, tested the effect
of zinc on patients with BPH symptoms. All patients reported symptomatic improvements,
and 75% had palpable shrinkage of the prostate.(14)
Zinc not only inhibits the production of 5-alpha-reductase (thereby reducing the
levels of DHT), but it also helps the body excrete excess DHT.(15,16) Zinc has been
shown, in several controlled studies, to actually reverse prostate enlargement.
Any therapy using zinc supplementation must also include adequate intake of Vitamin
B6 -
However, zinc is poorly absorbed by the body on its own. Unless it is combined with
Vitamin B6, zinc cannot be converted into a form that is readily used by the prostate.
Therefore,
When men reach their 40's, PROLACTIN levels tend to increase, which in turn encourages
the production of more 5-alpha-reductase. As we have already established, this enzyme
increases the amount of testosterone that is converted to dihydrotestosterone ...
and so we get prostate enlargement. Scientists believe that zinc is the natural
modulator of prolactin secretion by the pituitary gland. In fact, the combination
of Zinc and Vitamin B6 is so effective in reducing prolactin levels that many researchers
believe that a deficiency in either one might be a main cause of prostate enlargement.
Magnesium
Selenium
Vitamin D
Vitamin D
VITAMIN D AND PROSTATE CANCER MORTALITY
It is not all clear whether vitamin D influences the incidence of prostate cancer
and there is weak evidence that high levels of 25-hydroxyvitam D (25(OH)D) may even
correlate with the incidence of more aggressive forms of the disease, although a
clear monotonic dose-response is lacking. However, vitamin D levels as measured
by 25(OH)D appear to be strongly inversely correlated with progression and mortality
associated with established disease. A study just published from Norway addresses
this issue. This study involved 160 patients of which 97 were on hormone therapy.
During the follow-up which had a mean time of 44 months (range 1.2 to 155), 61 patients
died, the majority from prostate cancer. The vitamin D status was stratified according
to low (< 50 nmol/L), medium (50-80 nmol/L and high (> 80 nmol/L) of 25(OH)D.
The results were analyzed using several models, with the model which included age,
tumor grade (differentiation) and patient functional status at the time of blood
collection giving the strongest correlation between mortality from prostate cancer
and vitamin D status, When those in the medium and high levels were compared to
those with a low level of 25(OH)D, statistically significant risk reductions in
prostate cancer-specific mortality of 67% and 84% respectively were found. When
the analysis was restricted to patients receiving hormone therapy, the association
was even stronger. It was concluded that the serum level of 25(OH)D may be involved
in disease progression and is a potential marker of prognosis in patients with prostate
cancer.
It is possible that the mechanism providing this benefit may involve a transcription
factor called Stat3 which in active in malignant prostate cancer. Dr. William Grant
of the Sunlight, Nutrition and Health Research Center in San Francisco has pointed
out that vitamin D has been found to inhibit the action of Stat3 and increase cancer
cell death and invasion and metastasis. It is also possible that the metabolite
of 25(OH)D, 1,25-dihydroxyvitamin D is involved since it is known that prostate
cancer cells contain the required enzyme to convert 25(OH)D to this metabolite.
Grant points out that making sure that those diagnosed with prostate cancer have
high 25(OH)D levels may be important for this reason.
Ahn J, Peters U, Albanes D et al. Serum vitamin D concentration and prostate cancer
risk: a nested case-control study. J Natl Cancer Inst 2008 June 4;100(11):796-804
Tretli S, Hernes E, Berg JP, Hestvik UE, Robsahm TE. Association between serum 25(OH)D
and death from prostate cancer. Br J Cancer 2009 Feb 10;100(3):450-4
Abdulghani J, Gu L, Dagvadorj A et al. Stat3 promotes metastatic progression of
prostate cancer. Am J Pathol 2008 June 1;172(6):1717-28
Grant WB. Vitamin D may reduce prostate cancer metastasis by several mechanisms
including blocking Stat3. Am J Pathol 2008 November 1;173(5):1589-90
Vitamin E and prostate Cancer
Vitamin E - 400 units (Please note: Only natural vitamin E should
be used, not synthetic. Additionally, mixed tocopherol is more preferable
than alpha-tocopherol, as the gamma tocopherols are particularly useful antioxidants.)
Investigation of the antiproliferative effect
of tocotrienols in PC3 and LNCaP prostate
cancer cells suggests that the transformation of vitamin E to carboxyethyl-hydroxychroman
(CEHC) is mostly a detoxification mechanism,
useful to maintain the malignant properties of prostate cancer cells.[62] However,
various research studies suggest that both δ- and γ-tocotrienol potently suppressed
prostate cancer cell proliferation.[63] In
one study,the antiproliferative effect of γ-tocotrienol act through multiple-signalling
pathways (NF-B, EGF-R and Id family proteins). In addition, the same study demonstrated
the anti-invasion and chemosensitisation effect of γ-tocotrienol against PCa cells.[64]
In another study, δ-tocotrienol was at least equally or more potent than γ-tocotrienol
in prostate cancer cells, and showed that alpha-tocopherol enhanced cancer cell
growth.[65]
???
65. Campbell SE, Rudder B, Phillips RB, et al. (May 2011). "γ-Tocotrienol
induces growth arrest through a novel pathway with TGFβ2 in prostate cancer". Free
Radic. Biol. Med. 50 (10): 1344-54. doi:10.1016/j.freeradbiomed.2011.02.007.PMID 21335085.
" We find that the γ and δ isoforms of tocotrienol are more effective at
inhibiting the growth of prostate cancer cell lines (PC-3 and LNCaP) compared with
the γ and δ forms of tocopherol."
Four years ago there was a study that showed there was a 500 % decrease in prostate
cancer in men who had the highest level of gamma-tocopherol.
Vitamin E appears to protect against prostate cancer, and new research shows
it may do so by interfering with two proteins that are associated with the disease.
Researchers based at the University of Rochester in New York found that adding
vitamin E to prostate cancer cells inhibits the production of androgen receptor
(AR), which is needed in order for the cancer to grow and develop.
The fewer ARs there are in a prostate cancer cell, the less capable the remaining
ARs, no matter how they are activated, are to turn on the genes that stimulate prostate
cancer growth and progression.
Thus, this can be combined with other AR inhibiting strategies to eliminate AR
activity in prostate cancer cells.
In the US, prostate cancer is the second-leading cause of cancer death among
men. Previous research has shown that vitamin E can protect against the development
of prostate cancer, reducing risk from 18% to 12% among male smokers.
However, researchers remained puzzled about how vitamin E, and not other antioxidants,
lowered the risk of prostate cancer.
Now, the authors of the current study, led by, report that vitamin E inhibits
the expression in prostate cancer cells of prostate-specific antigen (PSA), a protein
that is often elevated in the disease and used as a marker for early detection.
The investigators also note in the May 28th issue of the Proceedings of the National
Academy of Sciences that vitamin E can prevent cells from making androgen receptors.
In an interview with Reuters Health, Messing said he suspects the benefits of
vitamin E stem from its interference with AR production. "The only thing we know
of in 2002 that turns on PSA is an activated AR."
Moreover, the researcher added, stopping the production of AR will halt the expression
of all other genes that are activated by AR, which can also influence the development
of prostate cancer.
While PSA serves as a good marker molecule of AR activity, more importantly the
genes responsible for prostate cancer"s growth, invasion and metastases, many of
which depend upon an activated AR to turn them on, will be down-regulated or totally
silenced as well.
All of the currently available treatments that aim to inhibit AR in prostate
cancer cells primarily focus on preventing testosterone from binding to the receptor,
Messing explained, but do not have long-term benefits, and can produce serious side
effects in other parts of the body.
This is the first study to show how an agent can, in fact, specifically inhibit
a prostate cancer cell"s ability to manufacture AR, Messing added, and the vitamin
appears to affect mostly prostate cancer cells.
Vitamin E might work best when administered with other natural treatments that
also appear to protect against prostate cancer, such as vitamin D and selenium.
Proceedings of the National Academy of Sciences May 28, 2002;99:7408-7413
Further evidence of vitamin E"s usefulness in treating prostate cancer. Now,
we actually have a mechanism for how it works.
Sunlight
Beta Sitosterol
Beta sitosterol has been shown to inhibit 5 alpha-reductase, which converts testosterone
to 5 hydroxytestosterone (5HT) RUBBISH!!!!.[ Cabeza M et al. Effect of beta-sitosterol
as inhibitor of 5 alpha-reductase in hamster prostate. Proc West PharmacolSoc 2003,
46:153-55.] - 5HT may be an undesirable metabolite of testosterone. Beta sitosterol
has also been used to treat BPH, where 5HT is believed to play a negative role.[11,12]
Black Cohosh
•
Shown to kill both androgen-responsive and non-responsive human prostate cancer
cells
• 4.12.
Black Cohosh (Actaea racemosa)
• Black
cohosh (Actaea racemosa) is a plant of the buttercup family. Extracts from these
plants are thought to possess analgesic, sedative, and anti-inflammatory properties.
Black cohosh preparations (tinctures or tablets of dried materials) are used to
treat symptoms associated with menopause, such as hot flashes, although the efficacy
has been questioned (11).
The inhibitory effects of black cohosh extracts (Cimicifuga syn. Actaea
racemosa L.) on the proliferation of human breast cancer cells has been reported
recently (12),
and Hostsanka. et al (13)
have examined the plant'seffects on prostate cancer, another androgen hormone-dependent,
epidemiologically important tumor. In that study, the inhibitory effect of an isopropanolic
extract of black cohosh (iCR) on cell growth in androgen-sensitive LNCaP and androgen-insensitive
PC-3 and DU 145 prostate cancer cells was investigated.
• The
authors found that regardless of hormone sensitivity, the growth of prostate cancer
cells was significantly and dose-dependently down regulated by iCR. At a concentration
between 37.1 and 62.7 μg/ml, iCR caused 50% cell growth inhibition in all cell lines
after 72h. Increases in the levels of the apoptosis-related M30 antigen of approximately
1.8-, 5.9-, and 5.3-fold over untreated controls were observed in black cohosh-treated
PC-3, DU 145, and LNCaP cells, respectively, with the induction of apoptosis being
dose- and time-dependent.
• Black
cohosh extract was therefore shown to kill both androgen-responsive and non-responsive
human prostate cancer cells by induction of apoptosis and activation of caspases.
This finding suggested that the cells’ hormone responsive status was not a major
determinant of the response to the iCR, and indicated that the extract may represent
a novel therapeutic approach for the treatment of prostate cancer.
Saw Palmetto
DIM
DIM may reduce
prostate cancer
incidence as it has been shown to stop human cancer cells from growing (by 54-61%)
and provokes the cells to self-destruct (apoptosis).
DIM also improves prostate function.
In two papers published in the Journal of Biological Chemistry (Mar 27, 2003) researchers
reported that DIM significantly halted proliferation of androgen-dependent human
prostate cancer cells. In one of the studies, androgen-dependent prostate cancer
cells treated with DIM grew 70% less than androgen-dependent untreated cells. DIM
also inhibited
dihydrotestosterone
(DHT)
stimulation of DNA synthesis in the androgen-dependent cancer cells. These effects
were not seen in androgen-independent prostate cancer cells.
To determine whether men are at risk for prostate cancer, they are usually tested
for levels of prostate-specific
antigen (PSA),
a growth factor for prostate cancer. In prostate cancer cells, DIM reduced intracellular
and secreted PSA protein levels caused by
DHT.
The researchers determined that DIM'smolecular structure is similar to Casodex,
a synthetic anti-androgen drug.
"As far as we know, this is the first plant-derived chemical discovered that acts
as an anti-androgen," said Leonard Bjeldanes, professor and chair of nutritional
sciences and toxicology at UC Berkeley's College of Natural Resources and principal
investigator of the study. "This is of considerable interest in the development
of therapeutics and preventive agents for prostate cancer."
Flaxseed
• Freshly
Ground Flaxseeds -
two ounces every other day????. I TABLEspoon flax seed is 0.25 oz (7g)
•
Consume ? TABLEspoons ground flaxseed daily with a drink - its phytoestrogen content
has an anti-estrogenic effect at this dose.
•
Freshly Ground Flaxseeds -
two ounces every other day
•
- TESTOSTERONE blocker in prostate cancer patients
- researchers at Duke University found that supplementation with milled flax resulted
in significant decreases in both total and free TESTOSTERONE in prostate cancer
patients. They also found a decrease in PSA levels in men with early stage prostate
cancer.
Mammalian Lignans - copy in AAAHYAH FILES
Role of Mammalian Lignans in the Prevention and Treatment of Prostate Cancer
Mark J. McCann, Chris I. R. Gill, Hugh McGlynn, and Ian R. Rowland
Green Tea
green tea may also have an important anti-androgen effect because it contains
epigallocatechins, which inhibit the 5-alpha-reductase conversion of normal testosterone
into DHT. As previously noted, this anti-androgen mechanism may help to reduce the
risk of BPH, acne, and baldness. As yet, no randomized controlled trials of green
tea for these androgen dependent conditions have been conducted.
Hormone Tests
Serum hormone levels are irrelevant
All steroid hormones are fat-soluble.
Sometimes steroid hormones are protein-bound to make them water-soluble (but
less bioavailable) for circulation through liver and kidneys (where they are excreted
in urine)
Non-protein-bound hormone ( "free"hormone) is the bioavailable form -
being fat-soluble, it is carried in the blood by red blood cells rather than in
serum ( watery, non-cellular portion of the blood).
When the blood circulates through the tissue of the salivary glands, the "free"hormone, whether in red blood cells or in the serum, filters through into the saliva,
whereas the protein-bound form does not. If one wished to know the concentration
of "free"bioavailable hormone in the blood, it is obvious that saliva hormone levels
are more accurate and more relevant than serum hormone levels.
♦
Only salivary measurements of "free"/bioavailable hormones are relevant
- Steroid hormones are fat-soluble and in
this form are "free"and bioavailable - fat-soluble/"free") hormones are carried
in the blood by red blood cells (RBCs) rather than in serum (watery, non-cellular
portion of the blood).
-
Serum levels reflect the not-so-available steroid hormones bound to protein - to
make them water-soluble for circulation through liver and kidneys (where they are
excreted in urine).
- Blood circulates through salivary gland tissue
and the "free"hormone in RBCs (or the small amount in serum) filters through
into the saliva - whereas the protein-bound form does not.
Serum vs. Saliva Holds True for Men Too
For reasons that escape rational thinking, conventional medicine persists in
using serum tests rather than saliva tests. The results have been disastrous. When
using hormone creams or gels, the hormone is absorbed through the skin and into
the blood without first passing through the liver. Thus, they are essentially all
absorbed in the "free"form. When given orally, they pass first through the liver
and 90% of them become protein-bound. For this reason, transdermal dosing is at
least 10 times more efficient than oral dosing. If one uses serum testing to measure
the blood levels achieved by transdermal dosing, the test will fail to measure all
the hormone carried by red blood cells. As a consequence, physicians are apt to
greatly over-dose their patients.
When using saliva testing,
it is found that the transdermal dose of testosterone when treating someone with
testosterone deficiency is only 0.25-0.5 mg in women, and 1-2 mg in men. As the
New Yorker article indicated, the transdermal doses of testosterone ranged from
5 mg to 100 mg a day. The same is observed in estrogen replacement therapy the doses
are generally all greatly excessive. The same hormone that brought good health without
side effects when in normal endogenous levels will bring on very bad side effects
when given in grossly excessive doses.
The problem is not the hormone, per se, the problem is the dosing.
Some physicians have attempted to measure "free"hormones in serum. Regardless
of how well this is done, such tests fail to measure the "free"hormone being carried
by red blood cells.
Magnesium
- Without sufficient magnesium, the body accumulates toxins and acid residues,
degenerates rapidly, and ages prematurely. It goes against a slew of medical science
to ignore magnesium chloride used transdermally in the treatment of any chronic
or acute disorder, especially cancer.
Learn more:
http://www.naturalnews.com/023279_magnesium_cancer_calcium.html#ixzz17kStwGax
Article talks about prostate cancer and calcium ND BALANCING CALCIUM WITH MAGNESIUM
http://www.naturalnews.com/023279_magnesium_cancer_calcium.html
For the cancer patient the transdermal approach combined with oral use offers
the opportunity to take magnesium levels up strongly and quickly.
-
For emergency situations - three applications a day;
-
For urgent situations - two treatments would be indicated though one strong treatment
with an ounce of a natural magnesium chloride solution spread all over the body
like a sun screen is a powerful systemic treatment.
Learn more:
http://www.naturalnews.com/023279_magnesium_cancer_calcium.html#ixzz17kUa5AiB
American Journal of Clinical Nutrition, Vol. 87, No. 4, 985-992, April 2008
© 2008 American Society for Nutrition
Nettle Root (Urtica doica)
Stinging nettle (extract) is anti-aromatase:
- Aphrodisiac effect on men by increasing
the level of free TESTOSTERONE in the blood -contain compounds that bind to SHBG,
reducing the binding of TESTOSTERONE to SHBG;
- Blocks binding of growth-stimulating estrogen to
prostate cells - Useful in treating benign prostatic hypertrophy (BPH);
- Natural aid for women who suffer from estrogen-related
stubborn fat.
• Nettle
root - contains compounds that bind to SHBG; nettle root is also anti-aromatase and
therefore acts against estrogen production.
•
A 30% methanol extract of Urtica dioica roots (10:1) markedly reduced activity of
5AR from rats at concentrations (12mg/mL).
•
However, in studies conducted by Rhodes et al, extract of Urtica roots (Bazoton)
failed to demonstrate 5aR inhibition in the rat anti-androgen assay, the rat androgen
receptor binding assay, and the assay for in vitro inhibition of human prostatic
5 alpha-reductase or a seven-day human clinical trial.
Pomegranate Juice
Pomegranate - ellagitannins (Ellagic acid) found in pomegranates inhibit ▼ aromatase; Urolithin
B, a metabolite produced from ellagic acid, significantly inhibited cell growth
in estrogen-responsive cancers.
Drinking pomegranate juice significantly increases PSA doubling time (PSADT)
- found a 2006 University of California (Los Angeles) study in 2006, for men with
rising PSA after surgical or radiation treatment for prostate cancer.
This study has been continued and patients remaining in the study continue to
show a durable increase in the PSADT as of August 2007. Patients remaining in the
study (active) were compared with those who no longer participate in the study (non-active).
At baseline, the active and non-active patients had similar PSA doubling times.
The mean post treatment PSADT increased in the non-active patients to 51 months,
but for the active patients, it increased to 69 months. The conference abstract
from which this information was derived does not indicate how many of the non-active
patients still drank pomegranate juice. The authors conclude that this research
reaffirms the positive results of the earlier trial by showing that the beneficial
effects of pomegranate juice on PSADTs in this clinical setting can be long-term.
Pantuck AJ, Leppert JT, Zomorodian N et al. Phase II study of pomegranate juice
for men with rising prostate-specific antigen following surgery or radiation for
prostate cancer. Clin Cancer Res 2006 July 1;12(13):4018-26
Pantuck AJ, Zomorodian N, Belldegrun AS. Phase-II Study of pomegranate juice for
men with prostate cancer and increasing PSA. Curr Urol Rep 2006 January;7(1):7
Pantuck AJ, Zomorodian N, Seeram M et al. Long term follow up of pomegranate juice
for men with prostate cancer and rising PSA shows durable improvements in PSA doubling
time. American Society of Clinical Oncology 2008 Genitourinary Cancers Symposium
Abstract 40. 2009
POMEGRANATE JUICE FOR A RISING PSA
For individuals with PSA doubling times greater than 12 months who are on "observation"
only, recent results from the University of California at Los Angeles may be of
considerable interest. In this study participants who had been treated for prostate
cancer with either surgery or radiation had rising post-treatment PSA with a level
greater than 0.2 but less than 5 ng/mL and a Gleason Score of equal to or less than
7. Participants had to have enough PSA data to calculate a doubling time, no hormonal
treatment prior to entering the study and no evidence of metastatic disease. In
what the authors claim is the first clinical trial of pomegranate juice therapy
for patients with recurrent prostate cancer; the protocol consisted of 8 ounces
of pure juice daily until disease progression endpoints were reached. Data from
46 patients were used in the analysis. The study used the brand POM Wonderful which
is widely available, both pure and diluted with other juices, in North American
grocery stores. After 33 months of follow-up, the mean PSA doubling time significantly
increased from 15 months at baseline to 54 months. In addition, 35% of the 46 patients
involved actually achieved a decrease in PSA (apparent arrested progression) during
the intervention and 4 achieved a PSA decline of greater than 50%. The authors point
out that the PSA doubling time is increasingly being seen as an important surrogate
biomarker for prostate cancer mortality, and men with greater doubling times can
expect longer survival. While the mechanism of action of pomegranate juice is unknown,
the authors discuss possibilities such as antioxidant and prostaglandin-inhibitory
actions of the polyphenols present in the juice and the ability of these polyphenols
to promote tumor cell death and inhibit proliferation and invasion.
Pantuck AJ et al., 2006. Phase II study of pomegranate juice for men with rising
prostate-specific antigen following surgery or radiation for prostate cancer. Clin
Cancer Res. 12(13):4018-PROGESTERONE - 5a-reductase and aromatase inhibitor
PROGESTERONE - supplementation / replacement provides a simple, safe, inexpensive
solution to prevent and treat prostate cancer (and BPH) by preventing both DHT and
estrogen production
PROGESTERONE levels decrease around the age of 45, especially after 60 - When
PROGESTERONE levels decrease, the 5-alpha reductase enzyme converts the TESTOSTERONE
to DHT, which unlike TESTOSTERONE is unable to remove the prostate cancer cells
stimulated by ESTRADIOL.
With a family history of prostate cancer men should consider natural progesterone
replacement sometime in their 40s, or even earlier. Males produce about half as
much progesterone as females.
• PROGESTERONE
inhibits 5 alpha-reductase much more effectively than Proscar (Finasteride) or Saw
Palmetto, the typical methods employed.
• PROGESTERONE
is a natural inhibitor of the aromatase enzyme - preventing conversion of androgens
to estrogen - of concern when using 5 alpha-reductase inhibitors, since they are
reported to push testosterone to ESTRADIOL pathway.
• PROGESTERONE
replacement completely reverses metastatic prostatic cancers - Renowned author and
proponent of hormone replacement therapy, Dr. John Lee, has a large number of anecdotal
stories.
Research Studies in Support of PROGESTERONE against
PCa and BPH
• In
1988 a very important study was done at Nanjing Medical College in China where progesterone
reduced the prostate weights of test animals.
• Six
different studies at the University of Milan in Italy, the University of Turku in
Finland, Montreal General Hospital in Quebec, St. George's Hospital in London, the
University of Mainz in Germany and the Roswell Park Memorial Institute in New York
all independently had results that suggest that progesterone is a powerful 5-alpha
reductase inhibitor that stops the conversion of testosterone into DHT in test animals.
• At
Staten Island College in New York and Mt. Sinai Medical School (also in New York
) PROGESTERONE was shown to raise the level of ANDROSTENEDIONE in the prostate gland
itself. Remember that a healthy prostate needs an abundance of androgens such as
testosterone and androstenedione and DHEA to function well as it does in your youth.
• At
the University of Maryland in Baltimore human prostate cells were shown to have
progesterone receptor sites. This was also demonstrated at the Institute of Clinical
Medicine in Rome.
• The
Center for Drug Research in India did four different studies suggesting that progesterone
shrank enlarged rat prostates, progesterone antagonized the stimulating effects
of estrogen, that progesterone stimulates alkaline phosphatase and depressed acid
phosphatase in the prostate and generally is supportive of proper prostate function.
• At
the University of Laval in Quebec progesterone inhibited estrogen from binding to
the prostate and progesterone receptors were clearly demonstrated.
• At
the Institute for Biological Medical Experiments in Buenos Aires it was shown progesterone
shrank prostate weight in test animals as well as reduced 5-alpha reductase activity.
• At
Central Hospital University in Paris PROGESTERONE was shown to inhibit the formation
of DHT as well as binding of it to the prostate. DHT content in the prostate is
the single most causative factor in prostate disease.
• At
the Biochemical Medical Laboratory in France the doctors demonstrated in human BPH
tissue there are more progesterone receptors which show how responsive the prostate
is to this hormone.
• At
the Institute of Clinical Chemistry in Bochum, Germany progesterone in human BPH
tissue reduced the activity of 5-alpha reductase strongly.
Progesterone Supplementation
If a saliva test shows low
PROGESTERONE, then supplemental PROGESTERONE is also indicated - since it
inhibits 5-alpha reductase, the enzyme catalyst for the conversion of TESTOSTERONE
to dihydrotestosterone (DHT), and high DHT levels are correlated with prostate cancer
Topical PROGESTERONE cream enters from the skin
into the fat. Progesterone is released in direct proportion to the concentration
of the cream. A low dose progesterone (E.g. 1.7% concentration) is released
smoothly and gradually from the fat into the blood stream over the course of 12
hours as opposed to a higher concentration (Eg. 10%) which will quickly enter the
blood stream. Since Progesterone has a half life of only 5 minutes in the blood
stream, a high dose cream is not satisfactory. The dose for a man is 6g (1/16 TEAspoon
twice daily 12 hours apart
â— Estrogens, or female hormones
not only suppress the production of testosterone but also have a negative effect
on prostate cancer cells and are sometimes used in cases of hormone resistant cancer
or sometimes as early therapy. Unfortunately, high dose estrogens have been
shown to cause increased blood clotting, leading to clots, heart attacks, strokes
and vascular accidents. DES, diethylstilbestrol, is still used in some patients.
Occasionally it is used in low dose in patients with hormone resistant prostate
cancer with some response."The research showed that drugs that activate one of the
two estrogen receptors, causes cell death. The team used a drug developed to selectively
and specifically activate the beta estrogen receptor in the prostate. "It not only
inhibits the growth of prostate cancer but also kills off cancer cells that are
resistant to conventional treatment such as androgen deprivation therapy;
Prostate Cancer / BPH Treatment
-
Increase TESTOSTERONE to ESTRADIOL RATIO
Hormonal balance refers to levels of hormones relative
to each other
rather than absolute levels of any given
hormone
Overview
♦
In prostate cancer, the key hormonal balance to address is TESTOSTERONE compared
to estrogen - TESTOSTERONE is a potent antagonist of ESTRADIOL (i.e. blocks
effects of ESTRADIOL)
-
The ESTRADIOL level in a 55 year old man is usually a little higher than a woman
of the same age
-
As men age, their TESTOSTERONE concentrations decline but their ESTRADIOL concentrations
increase - resulting in a decrease in the ratio of TESTOSTERONE to ESTRADIOL;
it is also noted that the level of PROGESTERONE (another antagonist to estrogen) also
generally falls; the result is an estrogen dominance over TESTOSTERONE, which
allows the cell-multiplying effects of estrogen to prevail, possibly causing enlarged
breasts, BPH or prostate cancer
-
With BPH or prostate cancer, the T : E ratio needs to be increased - either
by increasing TESTOSTERONE levels and/or by decreasing estrogen levels.
♦
Saliva test your hormone levels - Serum tests can NOT measure the fat-soluble /
"free"/ bioavailable hormone that is carried inside RBCs
♦
Oral vs. Transdermal Hormones
-
Oral hormones must first pass through the liver - where ~90% are bound to protein
for transportation in "watery"serum
-
Transdermal hormones pass into the blood in their "free"/ bioavailable form - i.e.
without being bound to protein
TESTOSTERONE + PROGESTERONE Hormonal Therapy
♦
Treatment strategy
♦
Use Only Bio-identical, Natural Hormones -Altered, synthetic versions of our natural
hormones do not convey the same benefits as the real hormone, and are fraught with
undesirable side effects not experienced by the real hormone.
Mercola will be offering one of
the best low dose creams on the market, Natragest, which we obtain from Biotics
Labs.
(1)
Supplement TESTOSTERONE - Dr. Lee recommended 4-6 mg delivered as a transdermal
cream or a patch, emphasizing that higher doses could "tip the hormonal scales"in the other direction, causing any number of emotional and physical effects. Also,
be aware that the "right"TESTOSTERONE levels vary from person to person.
Test kits enable you to send in a spit sample to accurately check for TESTOSTERONE
deficiency or excess:
Testosterone
Test
(2)
If a saliva test shows low PROGESTERONE, then supplemental PROGESTERONE is also
indicated - since it inhibits 5-alpha reductase, the enzyme catalyst for the
conversion of TESTOSTERONE to dihydrotestosterone (DHT), and high DHT levels are
correlated with prostate cancer
There is also a reasonable likelihood that this will decrease male balding.
Saw Palmetto - 5a-reductase inhibitor
Saw palmetto is
an herbal remedy that comes from a type of palm tree. It'sbeen used in traditional
medicine for centuries to relieve urinary symptoms, including those caused by an
enlarged prostate. Saw palmetto is also the leading herbal treatment for BPH. This
herb brings relief to 1 out of 3 men. It blocks the production of the hormone that
causes the prostate to grow. There is no documented evidence of any side effects
to taking saw
palmetto.
Saw palmetto is used to treat prostate cancer and symptoms of benign prostatic
hyperplasia, including reduction of urinary frequency, increase of urinary flow,
and decrease of nocturia. Saw palmetto may delay the need for prostate surgery.
However, the mechanism of action is unknown.
Saw Palmetto Dosing
The crude saw palmetto berries are usually administered at 1 to 2 g/day; however,
lipophilic extracts standardized to 85% to 95% fatty acids in soft native extract
or 25% fatty acids in a dry extract are more common. Brand-name products include
Permixon , Prostaserene , Prostagutt , Remigeron , Quanterra Prostate , and LG 166/S
. Typical dosages of standardized extracts range from 100 to 400 mg given twice
daily for benign prostatic hypertrophy.
♦
Extracts of saw palmetto berries (Serenoa repens) is a 5a-reductase inhibitor preventing
T from creating excessive amounts of the hormones DHT and ANDROSTENEDIONE ? - which
can otherwise cause cells to multiply in the prostate. Your extract should be 85%
to 95% fatty acids and sterols.
There are many clinical studies on saw palmetto. Saw palmetto was actually one
of the first prostate drugs in the US, marketed by Eli Lilly Company in the early
1870's.
"The mechanism of action of saw palmetto is not fully clear," Dr. Moerck
says. "We are certainly not making any drug claims, but the anecdotal evidence
suggests that there is a reduction in the conversion of testosterone into the dihydrotestosterone,
and therefore, men that take saw palmetto will have slightly higher levels of testosterone
in their body…That's a good thing...
It turns out that if you don't have enough testosterone in your body it can cause
all kinds of problems like gaining weight, breast enlargement in men, and problem
with urinating. So saw palmetto alone, or with pumpkin seed or lycopene is an interesting
proposition … It's something that you should definitely try."
Saw palmetto:
• Increases
DHT breakdown
• Inhibits
DHT production
• Reduces
5 alpha-reductase activity
• Inhibits
DHT binding to androgen receptor sites
Suggested Dosage Capsule: 400mg capsule a day
Suggested Dosage Liquid Extract: 1 tsp. liquid extract a day
Selenium
• 400
mcg /day
• Some
excellent food sources of selenium include (they are grown in ideal soil conditions):
§ Brazil nuts (which average about 70-90 micrograms per nut)
§ Button mushrooms and shitake mushrooms
§ Eggs
§ Sunflower seeds
§ Mustard seeds
TESTOSTERONE Hormonal Therapy
♦ Use Only Bio-identical, Natural Hormones -Altered,
synthetic versions of our natural hormones do not convey the same benefits as the
real hormone, and are fraught with undesirable side effects not experienced by the
real hormone.
TESTOSTERONE, MALE MENOPAUSE AND HORMONE BALANCE IN MEN
by John R. Lee, M.D.
Medicine'sLack of Understanding about Male Hormone Balance
TESTOSTERONE supplementation is the obvious treatment ????(Not if it turns on
BCl-2 and turns off P-53!!!!) for men with TESTOSTERONE deficiency relative
to their estradiol levels. If the estradiol, progesterone, and testosterone balance
that prevails in younger men (when they do not get prostate cancer) is a healthy
one, why not restore the hormone levels in older men to that same healthy balance?
To achieve this desired goal of a healthy balance between these major sex hormones,
one must learn how to accurately measure their levels.
Sometimes steroid hormones are protein-bound to make them water-soluble (but
less bioavailable) for circulation through liver and kidneys (where they are excreted
in urine)
Non-protein-bound hormone ( "free"hormone) is the bioavailable form -
being fat-soluble, it is carried in the blood by red blood cells rather than in
serum ( watery, non-cellular portion of the blood).
When the blood circulates through the tissue of the salivary glands, the "free"hormone, whether in red blood cells or in the serum, filters through into the saliva,
whereas the protein-bound form does not. If one wished to know the concentration
of "free"bioavailable hormone in the blood, it is obvious that saliva hormone levels
are more accurate and more relevant than serum hormone levels.
Supplement TESTOSTERONE
- Dr. Lee recommended 4-6 mg delivered as a transdermal cream or a patch, emphasizing
that higher doses could "tip the hormonal scales"in the other direction, causing
any number of emotional and physical effects. Also, be aware that the "right"TESTOSTERONE
levels vary from person to person.
Test kits enable you to send in a spit sample to accurately check for TESTOSTERONE
deficiency or excess:
Testosterone
TestFoods
Tomatoes
Some studies suggest that high levels of lycopene in the blood are linked with
a lower risk of prostate cancer and may even help slow the spread of cancerous cells.
•
Lycopene is most effective if taken in natural form — that is, in food rather than
in a supplement — and is particularly potent in cooked tomatoes. You can add tomatoes
or tomato products to many dishes.
Tomato Study -. Harvard researchers discovered that men who ate 5 or more
tomatoes per week had a 40% less risk of developing prostate cancer than those who
did not eat tomatoes. [Alternatives, March 1995; 5: 21]
Prostate cancer and lycopene study
DETROIT, MICHIGAN. Epidemiological studies have shown that a high intake of tomatoes
markedly reduces the risk of prostate cancer. It is believed that this beneficial
effect is due to lycopene, the most common carotenoid in tomatoes. A team of researchers
from Wayne State University, McGill University, University of Maryland, and the
University of Hawaii has just concluded a clinical trial aimed at evaluating the
benefits of lycopene supplementation in prostate cancer patients. The study included
26 men with clinically localized prostate cancer who were scheduled to undergo radical
prostatectomy (removal of the prostate gland). The men were randomized into a control
group and an intervention group. The intervention group received one 15-mg lycopene
capsule with breakfast and dinner for three weeks prior to surgery. Blood samples
were taken before the start of supplementation and three weeks later just before
surgery. The removed tumors and surrounding tissue were examined by pathologists.
The researchers conclude that lycopene supplementation lowers PSA levels; they observed
an average 18 per cent decrease in the lycopene group as compared to a 14 per cent
increase in the control group. The level of the tumor suppressing protein Cx43 in
the malignant part of the tumor was found to be substantially higher in the lycopene
group. It was also apparent that tumors tended to be smaller and more sharply defined
(less encroachment into surrounding healthy tissue) in the lycopene group. No adverse
effects of the lycopene supplementation were reported by the patients or their physicians.
The researchers conclude that lycopene is likely to be beneficial for both prevention
and treatment of prostate cancer, but urge larger trials to confirm this.
Kucuk, Omer, et al. Phase II randomized clinical trial of lycopene supplementation
before radical prostatectomy. Cancer Epidemiology, Biomarkers & Prevention,
Vol. 10, August 2001, pp. 861-68 [72 references]
Garlic and Onions
Sulfur-rich Foods: Foods that are high in sulfur, such as garlic and onions,
assist the liver in eliminating toxins and estrogen from the body and thus can reduce
levels of the hormone. - See more at: http://www.prostate.net/prostate-health/testosterone-hormones-and-prostate-health/what-is-estrogen-estradiol/#sthash.JXAEKMyo.dpuf
BPH Treatments
• Alpha-blockers
for BPH- work by relaxing the smooth muscle around the bladder neck and within the
urethra to reduce obstruction and improve urine flow. E.g. Cardura®(doxazosin),
Flomax®(tamsulosin), Uroxatral (alfuzosin hydrochloride), and RapafloTM (silodosin). Common
side effects include: fatigue; dizziness; drowsiness; drop in blood pressure
(when going from a lying or sitting position to standing); and nasal congestion.
• 5-alpha
reductase inhibitor drugs - used in BPH / enlarged prostate E.g. Proscar®(finasteride) and Avodart (dutasteride). May also shrink prostate, not just stop
growth; Finasteride may prevent /delay the appearance of prostate cancer and
precipitate positive sexual side effects. [Thompson, Ian et al. The Influence of
Finasteride on the Development of Prostate Cancer. The New England Journal of Medicine
2003 349:215-224.]
