The balanced presence of eicosanoids in cell membranes determines how cells react to local problems
The eicosanoids are produced by omega-6 DGLA and AA, and omega-3 EPA present in cell membranes. Eicosanoids from omega-6 AA mostly have inflammatory "call-to-action" effects, such as increasing pain, causing blood to clot, raising body temperature, and constricting vessels, and eicosanoids from omega-6 DGLA and omega-3 EPA have anti-inflammatory, "back-to-normal" effects. Excessive or unresolved inflammation can lead to uncontrolled tissue damage and health problems.
Understand how "First Response" eicosanoids are VITAL FOR HEALTH
Δ6D and Δ5D enzymes Inhibited by: dietary imbalance of Omega-6 to Omega-3, altered/damaged fats, cholesterol, excessive long-chain SFAs (in meat and dairy), age>30, sugar, stress, drugs, alcohol, toxic chemicals, caffeine, High INSULIN, excessive palmitoleic acids (Eg in coconut oil), lack of required conversion minerals/vitamins (see chart)
OMEGA-6
FAMILY |
OMEGA-3
FAMILY |
||||||
LA
(Linoleic Acid - 18:2w6) In nut and seed oils, animal fats (especially grain-fed), spirulina, wheatgerm, and legumes |
ALA
(α-Linoleic Acid - 18:2w3) In Flaxseed, Chia seed, Walnut & Hemp Oil, grass-fed animal fats |
||||||
↓ | Converted by and COMPETING for Δ6D enzyme Requires: B6, Magnesium, Zinc |
↓ | |||||
GLA
(Gamma-linolenic Acid -18:3w6) In Blackcurrant, Borage, and Evening primrose oils |
SDA
(18:4w3) In Blackcurrant & other wild seed oils |
||||||
↓ | Elongase Enzyme | ↓ | |||||
DGLA
(20:3w6): In Mothers Milk Most potent anti-inflammatory EFA |
Eicosatetraenoic Acid |
||||||
↙ Preferred Pathway blocks LT4 |
↓ Blocked by EPA |
Converted by and COMPETING for Δ5D enzyme Requires Vitamin C, B3, Zinc |
↓ Δ5D Prefers this Pathway |
||||
|
AA
(Arachidonic Acid - 20:4w6 ) In Meat, Dairy, Eggs (major structural component in body; brain development in infants) Most potent inflammatory EFA |
EPA (Eicosapentaenoic acid 20:5w3) EPA (and DHA) In: Fish oil, grass-fed animal and poultry land animals' brains, testes, adrenals, eyeballs. Brown/red algae |
|||||
↓
COX-1 & COX-2 |
↓
COX-1 & COX-2 |
↓ 5-LOX (DGLA derivative: 15- hydroxyl blocks LT-4) Belch, 2000) |
↓
COX-1 & COX-2 |
↓ 5-LOX |
↕Elongase Docosa -pentaenoic Acid |
||
PGG1 ↓ PGH1 ↓ |
PGG2 ↓ PGH2 ↓ |
PGG3 ↓ PGH3 ↓ |
↕Δ4D |
||||
Prostanoids Prostaglandins/Thromboxanes |
Leuko- trienes |
Prostanoids | Leuko- trienes |
DHA (Docosa- hexanoic acid 22:6w3) For brain and nerve function (major structural component in brain. 40% of brain's membrane phospholipid fatty acids) |
|||
S1 PGs: PGA1 PGB1 PGC1 PGD1 PGE1 PGF1α PGI1 TXA1 TXB1 (PGE1 PGF1α TXA1 block LT4) |
S2 PGs: PGI2 (Prost -acyclin) PGD2 PGE2 (via PGE synthase) PGF2α |
S2 Throm- boxanes TXA2 TXB2 |
S4 LTs LTA4 LTB4 LTC4 LTD4 LTE4 (LTF4) Eoxins EX4 (from LT4s via 14,15 -LOX) |
S3 PGs: PGD3 PGE3 PGF3α PGI3 TXA3 (TXB3) |
S5 LTs: LTA5 LTB5 LTC5 LTD5 (LTE5) |
Enzymes:
"Lime green" for COX 1
"Purple" for COX-2
"Aqua" for LOX enzymes
Eicosanoids:
Eicosonoids are color-coded according to their usual type of activity. They are not necessarily differentiated as good and bad.
"Orange" represents activity altering the status quo, some increasing inflammation.
"Turqoise" represents more of a "calming down" / going-back-to-normal action and/or resolving the inflammation.
"Red" represents eicosonoids having an inflammatory effect
Understand how these "First Response" eicosanoids are VITAL FOR HEALTH
COX: Cycloxygenase enzyme LOX: Lipoxygenase enzyme
References
Belch JJ, Hill A (Jan 2000). "Evening primrose oil and borage oil in rheumatologic conditions". Am. J. Clin. Nutr. 71 (1 Suppl): 352S-6S. PubMed.
Chronic low-level inflammation (CLII) involved in almost all health problems
"The medical kit of the future"
General electrotherapy health benefits. Used systemically and/or locally at specific problem areas of the body, its effective application has many benefits:
Detoxification | Wellness / Healthy aging | Pain relief |
Relief from insomnia | Immune system restoral | Anti-Inflammatory |
Maximizes cellular energy production | Accelerated tissue /bone /scar healing |
Stress Reduction |
Muscle relaxation / rehabilitation | Increased blood oxygen / circulation |
+++ |
There are several reasonably affordable electrotherapy devices available for personal use. The following electrotherapies are those that have received a significant amount of positive feedback:
Pulsed Electromagnetic Field (PEMF) therapy |
Beck Protocol |
Rife therapy |
Ozone therapy |
Near Infrared (NIR) class 4 laser therapy |
Cranial Electrotherapy Stimulation (CES) applies specific frequency patterns to the head area, with the following benefits:
Balances neurotransmitters | Relieves pain | Treats depression |
Substance abuse withdrawal | Relieves insomnia | Relieve stress / anxiety |
Anti-Inflammatory | Fibromyalgia | +++ |