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Delivery route choices for progesterone: Oral

Delivery route choices for progesterone: Oral

NOT a good route for any Steroid hormones

80-90% of oral PROGESTERONE is destroyed in GI tract and liver (so-called “first pass”liver metabolism).   Even when micronized and in oil, or with fatty foods (it does not dissolve in water). PROGESTERONE does not have any natural reason to be in the GI tract, which is not an efficient transport route for any steroid hormone. Swallowed hormones encounter absorbing foods, but PROGESTERONE is not affected by stomach acid. “Survivors”must later be broken down by the liver, and since only 10-20% reaches target cells a dose 5 times higher than utilized is needed.

Simon JA, Robinson DE, Andrews MC, Hildebrand JR 3rd, Rocci MLJr, Blake RE, Hodgen GD. The absorption of oral micronized PROGESTERONE : the effect of food, dose proportionality, and comparison with intramuscular PROGESTERONE . Fertil Steril 1993;60:26- 33.[PubMed]

When processing PROGESTERONE , the liver creates >30 different metabolites.   These can have several undesirable side-effects. Notably 5a-reduced metabolites are known to cause neuropsychological side effects. Arafat et al addressed the sedative and hypnotic effects that may be mediated through these metabolites. The bioidentical PROGESTERONE Prometrium®can have several unpleasant side-effects.

KhalilNahoul, LouisDehennin, MichelJondet, MarcRoger. Profiles of plasma estrogens, PROGESTERONE and their metabolites after oral or vaginal administration of ESTRADIOL or PROGESTERONE . Volume 16, Issue 3 , Pages 185-202, May 1993 [Maturitas]

Arafat ES, Hargrove JT, Maxson WS, Desiderio DM, Wentz AC, Andersen RN.Sedative and hypnotic effects of oral administration of micronized PROGESTERONE may be mediated through its metabolites. Am J Obstet Gynecol. 1988 Nov;159(5):1203-9. [PubMed]



Attend to Diet, Lifestyle & Emotional State

N E W  S T A R T S

C-Reactive Protein - Reliable Inflammation Marker
hot flame


Chronic low-level inflammation (CLII) involved in almost all health problems

How to treat CLII

Pulsed Electromagnetic Field Therapy (PEMFT)


       "The medical kit of the future"

The Body Electric

General electrotherapy health benefits.   Used systemically and/or locally at specific problem areas of the body, its effective application has many benefits:

Detoxification Wellness / Healthy aging Pain relief 
Relief from insomnia Immune system restoral Anti-Inflammatory
Maximizes cellular energy production Accelerated tissue /bone
/scar healing
Stress Reduction
Muscle relaxation / rehabilitation Increased blood oxygen
/ circulation

There are several reasonably affordable electrotherapy devices available for personal use. The following electrotherapies are those that have received a significant amount of positive feedback:

Cranial Electrotherapy Stimulation (CES) applies specific frequency patterns to the head area, with the following benefits:

Balances neurotransmitters Relieves pain Treats depression
Substance abuse withdrawal Relieves insomnia Relieve stress / anxiety
Anti-Inflammatory Fibromyalgia +++