Hormone menubar
GSE
PROGESTERONE MENUBAR
Delivery route choices for PROGESTERONE: Topical /Epithelial delivery
Delivery route choices for PROGESTERONE: Topical / Epithelial
delivery
(i.e. via skin u sing hormonal cream/gel)
NOT for LONG-TERM USE - with prolonged use
PROGESTERONE can build up in fatty tissues,
where its constant release can result in an overdose
Using topical PROGESTERONE for systemic supplementation
Delivered transdermally,
PROGESTERONE
enters
the blood stream fully bio-available (i.e. not bound to protein
in serum). PROGESTERONE is absorbed through
the epithelial tissue of the skin and into the bloodstream without passing
through the liver. PROGESTERONE
is very apparent in saliva testing (a serum test will show little or no change,
since blood tests do not accurately reflect body's
PROGESTERONE status. See:
Testing for
Hormones );
Dermal fatigue from long-term skin application.
Used in the short-term a problem, identified as "dermal fatigue", has become apparent
with its long-term use
after a few weeks of applying cream to skin, the skin tissue fat cells
become saturated with PROGESTERONE (or
any other steroid hormone used), which results in disruptions to adrenal hormones,
such as DHEA ,
CORTISOL and
TESTOSTERONE . This not only stops the
effectiveness of the hormone, it may even make symptoms worse .
Users of transdermal
PROGESTERONE
cream long-term Those with excessively high
PROGESTERONE levels from using transdermal
supplementation may need to go off the cream for up to two years, to allow the excess
PROGESTERONE to leave their body.
Some topical PROGESTERONE applications for the benefit of the
skin itself
Good on piles or painful, achy or itchy areas.
Excellent for burns
Anti-aging on the face.
The cream can also be applied in the vagina or nose to counter dryness.
Topical PROGESTERONE application details
How often
Take at least three to seven days off every month
- 3 days for those women who experience a severe recurrence
of symptoms during the break; taking a break prevents one's body from developing
a resistance or tolerance to the
PROGESTERONE
.
Transdermal
PROGESTERONE
cream is better applied in split doses. To keep levels consistent; Divide into at least two doses if you are
using a high dose of
PROGESTERONE
Application areas
Neck, face, arms,
chest, legs, stomach, vagina, scrotum
Scrotal
Route (for delivery to the prostate gland in
men)
Special note for
scrotal
application (a good application area when used against
prostate cancer for delivery
to the prostate gland). Simply rubbing the
PROGESTERONE cream into the
scrotal area may allow
sufficient absorption of PROGESTERONE
- however, this author suggests using a small amount of the membrane
penetrant DMSO to carry the
PROGESTERONE
cream through the scrotal membrane to enhance absorption, DMSO must
be applied on clean, dry skin with clean hands. Application area must be allowed
to dry completely after application before being allowed to touch other material.
Do not attempt to use DMSO
without first getting to know how to use and handle it:
DMSO - Medicine Carrier / Cell membrane
Alternatively,
a World Intellectual
Property Organization patent (WO2005079317 )
describes the successful absorption of
PROGESTERONE through the scrotal
membranes using certain substances (polyethylene glycols or peptide/fatty acid complexes)
to
enhance absorption
"Permeation rate enhancers allow for rapid
absorption of the PROGESTERONE composition
across the scrotal sac, after which the lipophilic
PROGESTERONE hormone is stored in adipose
cells. After the PROGESTERONE hormone
reaches a saturation level in the adipose cells, it diffuses into the circulatory
system for eventual uptake by the prostate gland PROGESTERONE to the prostate gland."
Rub the
PROGESTERONE
cream into the skin
Skin comprises 95% kerotinocytes with many
PROGESTERONE
receptor
sites.
The skin must
be clean. Cleared of cosmetics
etc. cream is better absorbed when applied immediately after drying off after bath
or shower;
Rotate among three or four different skin sites
on different days. The larger the area of skin the dose is
spread on, the greater the absorption; areas typically used are neck, chest,
inner arms, inner thighs, and stomach
