In men and postmenopausal women, extragonadal sites are the major source for the LOW circulating ESTRADIOL, which is NOT a good indicator of tissue levels and is NOT the body's main driver of estrogenic activity. In fact, estrogen circulation levels actually reflect estrogen which has escaped from metabolism at extragonadal sites of production.
For example, the estrogen responsible for breast cancer development, maintenance of bone mineralization and cognitive function is not circulating estrogen, but rather that which is produced locally at these specific sites within the breast, bone and brain, respectively.
- Circulating, blood ESTRADIOL levels are actually higher in men than postmenopausal women -
• In males, concentration is ~2-3 ng/dl compared to postmenopausal women at ~1.5ng/dl. - ESTRADIOL production rate in blood is also significantly higher (25-40 μg/24 h) in men. Male levels of estrogen tend to increase with age (at the expense of TESTOSTERONE) due to increased aromatase activity
• Premenopausal women have an ESTRADIOL concentration of ~5.5.ng/dl in days 2-4 of menstrual cycle.
Circulating levels of pituitary and steroid hormones in postmenopausal women compared with levels in postmenopausal women studied during first week of the menstrual cycle (Days 2-4)
(To convert: pg/ml->Ng/dl, divide by 10)
Chronic low-level inflammation (CLII) involved in almost all health problems
"The medical kit of the future"
General electrotherapy health benefits. Used systemically and/or locally at specific problem areas of the body, its effective application has many benefits:
|Detoxification||Wellness / Healthy aging||Pain relief|
|Relief from insomnia||Immune system restoral||Anti-Inflammatory|
|Maximizes cellular energy production||Accelerated tissue /bone
|Muscle relaxation / rehabilitation||Increased blood oxygen
There are several reasonably affordable electrotherapy devices available for personal use. The following electrotherapies are those that have received a significant amount of positive feedback:
|Pulsed Electromagnetic Field (PEMF) therapy|
|Near Infrared (NIR) class 4 laser therapy|
Cranial Electrotherapy Stimulation (CES) applies specific frequency patterns to the head area, with the following benefits:
|Balances neurotransmitters||Relieves pain||Treats depression|
|Substance abuse withdrawal||Relieves insomnia||Relieve stress / anxiety|