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Binding affinity of different estrogens

•   ESTRADIOL binds equally well to both ER-α and ER-β

•   ESTRONE binds preferentially to ER-α

•   ESTRIOL (postmenopausal estrogen) and genistein (Isoflavones) bind preferentially to ER-β

ER amounts decrease significantly after menopause

ESTRADIOL increases number of ER-α and AR receptors

-   ESTRADIOL stimulates production of both ER-αreceptors and androgen receptors (Ars) - promoting a greater hormonal effect for estrogen and androgens;

-   Also, even a low dose of the synthetic estrogen bisphenol A (prolific in our world and bodies today - see xenoestrogens) has the same effect as natural ESTRADIOL.

Richter CA, JA Taylor, RL Ruhlen, WV Welshons and FS vom Saal. 2007. ESTRADIOL and bisphenol a stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells,. Environmental Health Perspectives, in press. Link

-   Stimulation is blocked by estrogen receptor antagonists - E.g. PROGESTERONE , tamoxifen,

ESTRADIOL is a relatively potent androgen receptor (AR) binder;

Nakla AM, Romas NA, Rosner W. ESTRADIOL Activates the Prostate Androgen Receptor and Prostate-specific Antigen Secretion through the Intermediacy of Sex Hormone-binding Globulin March 14, 1997 The Journal of Biological Chemistry, 272, 6838-6841. Jbc Abstract

RichterCA, JA Taylor, RL Ruhlen, WV Welshons and FS vom Saal. 2007. ESTRADIOL and bisphenol a stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells,. Environmental Health Perspectives, in press. Link

References

Leslie Baumann. Cosmetic Dermatology: Principles and Practice, Second EditionMcGraw Hill Professional,Apr 8, 2009


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