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Health Effects of Estrogen

Health effects of estrogen

effects of estrogen


Estrogen (mainly ESTRADIOL) has numerous effects in the body

Sex Differentiation

▪ Promotes formation of female secondary sex characteristics: growth of a girl's sex organs, breasts and pubic hair.

▪ Effeminization when estrogen to TESTOSTERONE ratio increases. E.g.  Breast growth, higher voice, loss of body hair, decrease in muscle mass, increase in fatty tissue, prostate enlargement, change in sex drive;

Protein Synthesis

Estrogen action: The role of specific RNA and protein synthesis;   

Reproductive Functions

▪ Decreases libido (sex drive);

▪ Helps regulate menstrual cycle;

Stimulates endometrial growth;

increases uterine growth;

ESTRIOL produced by placenta is involved with maintaining pregnancy and initiating labor.

Breast-feeding stimulates estrogen production - which stimulates production of the PROLACTIN hormone to increase milk production.

ESTRADIOL modulates sex drive, erectile function and spermotogenesis in men - for libido, estrogen is to men what TESTOSTERONE is to women.

Estrogen receptors and aromatase (enzyme that converts testosterone to estrogen) are abundant in brain, penis, and testes, organs important for sexual function. In the brain, estradiol synthesis is increased in areas related to sexual arousal. PubMed


Reproductive organ cancers

Promotes hormone-sensitive reproductive organ cancers - treatment of endometrial and breast cancer involves suppression of estrogen production; ESTRADIOL promotes an oncogene, Bcl-2 (expressed at high levels, oncogenes help turn a normal cell into a tumor cell).

ESTRADIOL increases expression of genes that are responsible for directing production of both androgen and estrogen hormone receptors.

Regulates Fluid balance

▪Regulates salt / water retention;

▪ Increases growth hormone;

Increases CORTISOL, SHBG (Sex-Hormone Binding Globulin) -binds ESTRADIOL (and TESTOSTERONE) in blood and thus inhibits their bioavailability, since only “free”hormones are active)


Accelerates height growth;

Reduces muscle mass;

Maintains blood vessels /skin;

Shortened height

▪ Can cause early epiphseal closure near the end of puberty - thus limiting height

Protects against heart disease / Blood Clotting

Increases HDL & triglycerides / Decrease LDL & fat deposition in coronary arteries;

▪ Blood Coagulation - Increase circulating level of factors 2, 7, 9, 10, antithrombin III, plasminogen / Increase platelet adhesiveness

GI Tract

Reduces bowel motility;

Increases cholesterol in bile;


Promotes lung function by supporting avioli

Preserves bone density

Helps decrease bone loss slightly - by slowing bone resorption (osteoclast activity); antagonizes the effects of PTH, minimizing the loss of calcium from bones,

Decreases fat burning

Increases subcutaneous fat deposits/decreases fat-burning by stimulating SNS.  As an Alpha 2 adrenergic agonist, estrogen increases/activates Alpha2 adrenoceptors (A2As), which inhibit fat burning (A2As react to neurotransmitters EPINEPHRINE, NOREPINEPHRINE, and isoprenaline, for a sympathetic effect; NOREPINEPHRINE is one of the body's primary fat burning agents), but when estrogen binds to the A2A (taking NOREPINEPHRINE's “seat”), it creates a negative feedback loop inhibiting the release of fat-burning NOREPINEPHRINE.


▪ Increases pheomelanin, reduces eumelanin

Anti-aging for Skin

Prevents decrease in skin collagen in post-menopausal women.    Topical and systemic estrogen therapy increases skin collagen content / skin thickness/ skin moisture (increases acid mucopolysaccharides and hyaluronic acid, and possibly maintains stratum corneum barrier function); Possible anti-wrinkle effect on elastic fibers;

See: ESTRIOL-The WEAK, Protective Estrogen


Attend to Diet, Lifestyle & Emotional State

N E W  S T A R T S

C-Reactive Protein - Reliable Inflammation Marker
hot flame


Chronic low-level inflammation (CLII) involved in almost all health problems

How to treat CLII

Pulsed Electromagnetic Field Therapy (PEMFT)


       "The medical kit of the future"

The Body Electric

General electrotherapy health benefits.   Used systemically and/or locally at specific problem areas of the body, its effective application has many benefits:

Detoxification Wellness / Healthy aging Pain relief 
Relief from insomnia Immune system restoral Anti-Inflammatory
Maximizes cellular energy production Accelerated tissue /bone
/scar healing
Stress Reduction
Muscle relaxation / rehabilitation Increased blood oxygen
/ circulation

There are several reasonably affordable electrotherapy devices available for personal use. The following electrotherapies are those that have received a significant amount of positive feedback:

Cranial Electrotherapy Stimulation (CES) applies specific frequency patterns to the head area, with the following benefits:

Balances neurotransmitters Relieves pain Treats depression
Substance abuse withdrawal Relieves insomnia Relieve stress / anxiety
Anti-Inflammatory Fibromyalgia +++