Magnesium / B vitamins aid liver's estrogen clearance

B vitamins (B6 in particular) and Magnesium have important roles in estrogen metabolism/clearance by the liver

A deficiency in either reduces liver's estrogen clearance rate.    Contributes to ED by increasing imbalance of estrogen to PROGESTERONE .

-    B6 has a role in the metabolism of estrogens.

Biskind, M.S.: Nutritional deficiency in the etiology of menorrhagia, cystic mastitis and premenstrual tension. Treatment with vitamin B complex. J. clin. Endocr. Metab. 3: 227-234 (1943).

Biskind, M.S.; Biskind, G.R.: Effect of vitamin B complex deficiency on inactivation of estrone in the liver. Endocrinology 31: 109-114 (1942).

Biskind, M.S.; Biskind, G.R.: Inactivation of TESTOSTERONE propionate in the liver during vitamin B complex deficiency. Alteration of the estrogen-androgen equilibrium. Endocrinology 32: 97-102 (1945).

Biskind, MS.; Biskind, GR.: Biskind, L.H.: Nutritional deficiency in the etiology of menorrhagia, metrorrhagia, cystic mastitis, and premenstrual tension. Surgery Gynec. Obstet. 78: 49-57 (1944)

-   Magnesium influences estrogen conjugation directly.   By increasing glucuronyl transferase activity, an enzyme involved in the hepatic glucuronidation of estrogens.

Brown, R.C.; Bidlack, W.R.: Regulation of glucuronlyl transferase by intracellular magnesium. Proc. Int. Symp. Magnesium and Its Relationship to Cardiovascular, Renal and Metabolic Disorders, Los Angeles1985.

B6 activation needs Magnesium and B2

Magnesium deficiency may lower liver's estrogen metabolism/clearance by decreasing the biological activity of B6

-   B6 (Pyridoxine) activation depends on magnesium and B2.    Pyridoxine  requires phosphorylation (requiring magnesium) and oxidation of pyridoxine phosphate (requiring B2) to become active.

-   In self preservation, Vitamin B6 increases active transport of minerals (such as magnesium) across cell membranes.    Study showed significant increase of magnesium transfer and therefore its utilization.

Abraham, G.E.; Schwartz, U.D.; Libran, M.M.: Effect of vitamin B-6 on plasma and red blood cell magnesium levels in premenopausal women. Ann. clin. Lab. Sci. 11: 333 (1981) [PubMed]

Lack of B6 may be responsible for the infamous "PMSing"

PMT-A is the most common of the premenstrual tension syndromes (PMTS).    Characterized by a premenstrual increase in anxiety, nervous tension, irritability and mood swings;

B6 increases DOPAMINE (the calming neurotransmitter).   As a cofactor in the conversion of CNS-active excitatory amino acids to the corresponding inhibitory amino acids. If B6 activation is blocked, an alternate pathway converts pyridoxine to pyridoxic acid, which is excreted in the urine . . . increased excretion of pyridoxic acid has been reported during the luteal (post ovulation/pre-menstrual) phase of the menstrual cycle.

Abraham, G.E.: Bioavailability of selected nutrients from a dietary supplement. Optivite for women. J. appl. Nutr. 37: 67 (1985).