Hormone menubar
Estrogens - The Female Hormones
Estrogens - Reduce - Mg and B6 Aid liver's estrogen clearance
Magnesium / B vitamins aid liver's
estrogen clearance
B vitamins
(B6 in particular )
and
Magnesium
have important roles in
estrogen
metabolism/clearance by the liver
A deficiency in either reduces
liver's
estrogen
clearance rate. Contributes to ED by increasing
imbalance of estrogen to
PROGESTERONE .
-
B6
has a role in the metabolism of
estrogens .
Biskind, M.S.: Nutritional deficiency in the etiology of
menorrhagia, cystic mastitis and premenstrual tension. Treatment with vitamin B
complex. J. clin. Endocr. Metab. 3: 227-234 (1943).
Biskind, M.S.; Biskind, G.R.: Effect of vitamin B complex
deficiency on inactivation of estrone in the liver. Endocrinology 31: 109-114
(1942).
Biskind, M.S.; Biskind, G.R.: Inactivation of TESTOSTERONE
propionate in the liver during vitamin B complex deficiency. Alteration of the
estrogen-androgen equilibrium. Endocrinology 32: 97-102 (1945).
Biskind, MS.; Biskind, GR.: Biskind, L.H.: Nutritional
deficiency in the etiology of menorrhagia, metrorrhagia, cystic mastitis, and
premenstrual tension. Surgery Gynec. Obstet. 78: 49-57 (1944)
- Magnesium
influences estrogen
conjugation directly. By increasing glucuronyl transferase
activity, an enzyme involved in the hepatic glucuronidation of estrogens.
Brown, R.C.; Bidlack, W.R.: Regulation of glucuronlyl
transferase by intracellular magnesium. Proc. Int. Symp. Magnesium and Its
Relationship to Cardiovascular, Renal and Metabolic Disorders, Los Angeles1985.
B6 activation needs
Magnesium and B2
Magnesium
deficiency may lower liver's estrogen
metabolism/clearance by decreasing the biological activity of
B6
- B6
(Pyridoxine)
magnesium and
B2.
Pyridoxine requires phosphorylation (requiring magnesium) and oxidation of pyridoxine phosphate (requiring B2 ) to become active.
- In self preservation,
Vitamin B6
increases active transport of minerals
(such as
magnesium)
across cell membranes. Study showed significant increase of magnesium transfer and therefore its utilization.
Abraham, G.E.; Schwartz, U.D.; Libran, M.M.: Effect of
vitamin B-6 on plasma and red blood cell magnesium levels in premenopausal
women. Ann. clin. Lab. Sci. 11: 333 (1981) [ PubMed ]
Lack of B6 may be
responsible for the infamous "PMSing"
PMT-A is the most
common of the premenstrual tension syndromes
(PMTS). Characterized by a premenstrual increase in anxiety, nervous tension, irritability and
mood swings;
B6
increases
DOPAMINE (the calming neurotransmitter). As a cofactor in the conversion of
CNS-active excitatory amino acids to the corresponding inhibitory amino acids.
If B6 activation is blocked, an alternate pathway converts pyridoxine to
pyridoxic acid, which is excreted in the urine . . . increased excretion of
pyridoxic acid has been reported during the luteal (post
ovulation/pre-menstrual) phase of the menstrual cycle.
Abraham, G.E.:
Bioavailability of selected nutrients from a dietary supplement. Optivite for
women. J. appl. Nutr. 37: 67 (1985).
