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ESTRIOL - The Weak Protective estrogen

ESTRIOL (E3) - The WEAK, Protective Estrogen

How to supplement ESTRIOL

Estriol is available as an oral supplement.   However, via this route, the ESTRIOL must navigate through the digestive system and the liver will "dump" approximately 75% of the estriol into the body's elimination channels. A typical 2-5mg dose will thus yield only about 0.5mg. of ESTRIOL whilst also burdening the liver.

Estriol is better delivered topically or intravaginally using an estriol cream.   The skin does not absorb ESTRIOL quite as well as ESTRADIOL or ESTRONE, but studies have shown that topical delivery is about 20 times more efficient than oral delivery. The skin and vaginal membranes also provide quite a steady supply of ESTRIOL until it clears the body - usually in 2 days.

Where to apply estriol cream?

It would make sense to apply cream in the area where it is needed.   If in the reproductive area, then rubbed inside the vagina or into the testicle skin. Alternatively, if using it to treat facial wrinkles, then apply to the face and neck.

Estrogen receptors have been identified in the vulva, vagina, bladder, urethra, pelvic floor musculature, and endopelvic fascia.    ESTRIOL has a binding affinity to vaginal ERs equal to ESTRADIOL,

-   Number of ERs varies by location:

•  Vaginal epithelium has highest ER concentration.    Also, the vagina has a high ER : PR ratio; in contrast,the vulva has high PR : ER ratio;

•  Cervix, uterine body and fallopian tubes.     Have high ER density

-    ER and PR concentration remains stable postmenopause.    However, AR (androgen receptor) concentration decreases by about half ;

Combine ESTRIOL therapy with . . .

PROGESTERONE.    To prevent hormone imbalance, any supplemental estrogen should be used together withwith Natural PROGESTERONE . According to Dr. Lee, most women become deficient in PROGESTERONE long before estrogen levels drop to the point of causing symptoms.

Vitamin E.    Administered at 400 IU / day with ESTRIOL therapy will improve ESTRIOL activity and effectiveness

How much and how often?

Use 0.5 mg - 0.75 mg topical or intravaginal ESTRIOL  cream every other day or just a few times a week  (responding to amount needed to control symptoms)     See ESTRIOL Health Benefits for doses used in studies for specific problems.

-   Why every other day?    ESTRIOL does not clear the body as fast as the other estrogens, usially taking 2 days. Thus, one dose will last  2 days for most women. Using more could result in excessively high doses in your body.

-   Example Cream: Life-Flo ® Estriol cream.    One full press of the pump contains 0.75mg natural ESTRIOL USP;

Take a break from using ESTRIOL at the same time you take a break from PROGESTERONE.    E.g. If you are postmenopausal or have had a hysterectomy, you use PROGESTERONE for only 3 weeks out of the month


Attend to Diet, Lifestyle & Emotional State

N E W  S T A R T S

C-Reactive Protein - Reliable Inflammation Marker
hot flame


Chronic low-level inflammation (CLII) involved in almost all health problems

How to treat CLII

Pulsed Electromagnetic Field Therapy (PEMFT)


       "The medical kit of the future"

The Body Electric

General electrotherapy health benefits.   Used systemically and/or locally at specific problem areas of the body, its effective application has many benefits:

Detoxification Wellness / Healthy aging Pain relief 
Relief from insomnia Immune system restoral Anti-Inflammatory
Maximizes cellular energy production Accelerated tissue /bone
/scar healing
Stress Reduction
Muscle relaxation / rehabilitation Increased blood oxygen
/ circulation

There are several reasonably affordable electrotherapy devices available for personal use. The following electrotherapies are those that have received a significant amount of positive feedback:

Cranial Electrotherapy Stimulation (CES) applies specific frequency patterns to the head area, with the following benefits:

Balances neurotransmitters Relieves pain Treats depression
Substance abuse withdrawal Relieves insomnia Relieve stress / anxiety
Anti-Inflammatory Fibromyalgia +++