ESTRIOL may not have its purported protective role if CONTINUOUSLY supplied

(E.g. by implants)

Potency of ESTRADIOL is not much different to ESTRONE and ESTRIOL WHEN THEY ARE CONTINUOUSLY SUPPLIED (E.g. by implants or a patch) - Earlier work from the Clark laboratory maintained that physiological Estrogens, other than ESTRADIOL, were not weak when their concentrations were maintained continuously by implants (as opposed to single injections), in which case, they could actually elicit tissue growth of the uterus.

Anderson, J. N., Peck, E. J., Jr., and Clark, J. H. (1975) estrogen-induced uterine responses and growth: relationship to receptor estrogen binding by uterine nuclei. Endocrinology 96, 160-167

Also, continuous administration of ESTRIOL was shown to induce breast tumors in rodents, whereas a single injection failed to induce tumors in susceptible rodent strains and appeared to block such induction by ESTRADIOL and ESTRONE.

In the 1940's, Alexander Lipshuts demonstrated that a CONTINUOUS, WEAK estrogenic stimulus was immensely effective in producing first fibromas, then cancer, in one organ after another.   The effect was not limited to the reproductive system. For example, the brain and liver, which also have estrogen receptors, may grow tumors too.

Townsend Letters for Doctors and Patients (January, 1997 issue), Ray Peat, a renowned biologist in the U.S.

ESTRIOL has been suggested as having a protective role in breast cancer based on the observation that oriental women who have a high ESTRIOL / (ESTRADIOL + ESTRONE) ratio in their blood also have a low incidence of breast cancer.

-   Soy bean (containing phytoestrogens) has also been suggested as being protective in breast cancer.   On the basis that Japanese women who consume much more soy bean than Western women have lower incidence of breast cancer.

-   However, in the past, oriental women took much less medical drugs including painkillers compared to women in Western societies.   Today, oriental breast cancer incidence has gone up significantly in recent years even though soy bean products are still consumed there much more than in Western societies - a trend that may in part be due to increased consumption of medications. The American Liver Foundation stated that the amount of medicine consumed has increased greatly with resulting dangers to the liver. The elevated estrogen level caused by a weak liver may not be detected in blood tests because blood estrogen levels do not necessarily reflect estrogen levels in tissues and estrogen levels in the tissues cannot be measured