Magnesium against estrogen dominance

High estrogen levels linked to deficiency in magnesium and B vitamins

Magnesium activates vitamin B6 needed for clearing estrogen from the liver.    Magnesium is needed for a phosphate transfer reaction that activates vitamin B6 (Pyridoxine). Thus a magnesium deficiency may affect hepatic  estrogen clearance by decreasing the biological activity of the B vitamins.

Reduce estrogen / Help liver better eliminate estrogen

Magnesium directly influences estrogen conjugation (in this bound form, estrogen can be eliminated from the body).    Magnesium increases activity of an enzyme (glucuronyl transferase) involved in the hepatic glucuronidation of estrogens (Estrogen is commonly bound to glucuronic acid forming a compound that can be excreted into bile and removed from the liver, and then excreted into the intestines for elimination from the body).