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CANCER MENUbar CANCER MENUbar Iodine Health - Iodine against Cancer

1-2-3 CANCER PLAN

(1) Cancer NOT Allowed

Iodine against Cancer

Iodine deficiency is strongly implicated in cancers of organs normally having a high iodine presence - including thyroid, breast,ovarian , prostate, stomach, pancreatic, colon and lung cancer.

 

Iodine sufficiency may be the most important preventative measure against reproductive organ cancers

Iodine has been found particularly effective against cancer of the breast, uterus, ovaries, endometrium, prostate and thyroid;

Stadel B, Dietary iodine and risk of breast, endometrial, and ovarian cancer, The Lancet, 19

Cancer is theorized to be roughly divided into two phases, and iodine plays a beneficial role in both phases

(especially in organs usually having high iodine presence)

This information sourced from http://thyroid.about.com/library/derry/bl1a.htm

(1) The pre-cancerous phase

(The development of abnormal, benign cells)

 

The first, long-term, pre-cancerous phase, is when normal cells gradually become abnormal cells – E.g. the discovered breast cancer lump represents the end stage of a slow development over ~20-30 years. The pre-cancerous lesions (lumpy, tender breasts) are known as FDB (Fibrocystic Disease of the Breast).

FDB - Link to breast cancer

APOPTOSIS

Appropriate and natural destruction of cells that represent a threat to the integrity of the organism – E.g. cancer cells and virus-infected cells.

Essential to growth and development - E.g. Fingers form in the fetus by apoptosis of the tissue between them;

When normal cells are damaged beyond repair, they are appropriately eliminated by apoptosis - the programmed or natural death of damaged, infected or malfunctioning cells.

Cancer cells avoid apoptosis and continue to multiply in an unregulated manner

Adequate Iodine stops and reverses the pre-cancerous stage of the cancer process by causing the natural death of abnormal cells (i.e apoptosis) – preventing them from becoming cancer cells. Sites of rapid apoptosis in the body are also sites with high iodine levels.

Inadequate iodine in a tissue allows abnormal cells to persist, allows cysts to grow, and may eventually lead to cancer

Dose to Prevent and Eliminate Pre-cancer cells? – An adequate dose of iodine to prevent pre-cancer phase (abnormal cells) may be defined as more than 3-4 mg / day. One drop of Lugol's in water, juice or milk or ½an Iodoral tablet (6.5 mg iodine / iodide) should both prevent cells from changing into cancer cells and gradually eliminate pre-cancer cells, so no new cancers can start. It will also kill abnormal cells floating around in the body at remote sites from the original cancer.

Ghent W R et al, Iodine replacement in fibrocystic disease of the breast. Can J Surg 1993; Ghent WR et al, Iodine deficiency breast syndrome. Frontiers in Thyroidology, 1986

(2) The multiplying phase of cancer

(a) Cancer cells can multiply and just stay where they are (carcinoma in situ)

or (b) Cancer cells can multiply and spread (metastasis)

 

On average, breast cancer cells double every 100 days, and it takes ~9 years before mammograms can pick them up.

Adequate thyroid hormone (produced by a normal thyroid with sufficient iodine), prevents the spread of cancer cells to other organs -The amount of thyroid hormone present in tissues controls the strength of connective tissue, which forms a strong sieve-like barrier to the passage of cancer cells trying to spread.

Clark WH, Tumour progression and the nature of cancer. J Cancer 1991;Smith,T.J. et al, Connective tissue, glycosaminoglycans, and diseases of the thyroid, Endocr.Rev, 1989

Iodine –Supplementation

When there is sufficient thyroid hormone present, then the cancer cannot spread – Conversely . . .

A low level of thyroid hormone in the tissues (especially connective tissues) allows cancer cells to spread

Adequate Iodine Dose to Prevent Cancer Spread? – You should do your own research on this. However, this author has so far found that the available literature indicates a dose of about 50mg iodine/iodide (8 drops 5% Lugol's Solution or 4 Iodoral ®) /day in split doses) according to tolerance, with the goal of achieving whole body iodine sufficiency (~1.5 g) in about 3-6 months.

–   Dr. Brownstein was using 200 to 300 mg with his prostate and breast cancer patients - with those who have metastases needing the highest dosages.

 

There is some overlapping of the two iodine defense systems - in the pre-cancer and multiplying phases.

How does iodine eliminate abnormal cells?

1. δ-Iodolactone is the main mediator for preventing cancer - this iodinated form of lactone (produced when iodide oxidizes polyunsaturated lipids) seems to be the main iodocompound which can inhibit growth and induce apoptosis in human thyroid carcinoma cell lines (B-CPAP cells, FTC-133 cells and 8505C cells) as well as on human breast cancer cells (MCF-7). Also, human lung cancer cells with genes spliced into them that enhance iodine uptake and utilization undergo apoptosis and shrink when given iodine, both in vitro and implanted in mice.

Cann Stephen A., van Netten Johannes P.,Glover David W. , Iodide Accumulation in Extrathyroidal Tissues, Journal of Clin. Endocrinology & Metabolism, 1999 ; Vol. 84, No. 2821

2. Iodine may also kill abnormal cells by the same method it destroys single-celled microbes – by reacting with exposed tyrosine. Once the thyroid gland has become iodine-saturated, most of the rest of the available iodine in the body then circulates throughout the body bathing the extracellular fluids found between body cells. If cell surface proteins have the amino acid tyrosine on the outside, the passing iodine reacts with this tyrosine. This reaction denatures the protein, and by disturbing the cell membrane, it thus kills the cell (This is the same chemical reaction by which iodine in dilute solutions causes the death of single-celled microbes – bacteria, viruses, fungi, and protozoa).

Healthy vertebrate cell membranes do not have tyrosine on the portion of the protein sticking out into the extracellular fluid. However, the intra membrane proteins may have tyrosine which is only exposed when the membrane is distorted by abnormal cell development such as we see in the pre-cancerous forms of Fibrocystic Disease of the Breast (FDB). This would then expose the tyrosine to the iodine passing in the extracellular fluid, enabling the iodine to do its work and kill off the cell.

Additional iodine roles in preventing cancer

Any excess iodine flows into the urine -preventing the development of abnormal cells in the bladder and kidney system, and thus also prevents cancers in those locations.

The antioxidant properties of iodides have a role in cancer prevention by their ability to markedly quench the high-energy, excited singlet oxygen to its less reactive triplet form, thus preventing singlet oxygen from causing oxidative damage to DNA.

Kasha M, Collisional Perturbation of Spin-Orbital Coupling and the Mechanism of Fluorescence Quenching. A Visual Demonstration of the Perturbation. The Journal of Chemical Physics, 1952.

Venturi S et al, Role of Iodine in Evolution and Carcinogenesis of Thyroid, Breast and Stomach, Adv. Clin. Path, 2000

Iodine is a powerful deactivator of environmental chemical toxinscancer-causing suspects, E.g. xenoestrogens, pesticides, herbicides, industrial chemicals;

The Overwhelming Evidence of iodine against Cancer

Spontaneous regression of breast cancer seen in 3 cases supplementing iodine

Please visit the following site to read information on these cases where iodine supplementation has shrunk tumors in the breast:

Jeffreydach.com

Supporting evidence for iodine deficiency involvement in breast cancer, fibrosis and painful breasts in FDB patients

Please see information at breastcancerchoices.org

-    Breastcancerchoices.org lists several of iodine's impressive abilities against cancer:

✔  Desensitizes estrogen receptors in the breast;

✔ Reduces estrogen production in overactive ovaries;

✔ Reduces fibrocystic breast disease which often precedes
breast cancer;

✔ Causes more cell death than the chemo drug, Fluorouracil;

✔ Prevents rats from getting cancer when fed the breast cancer causing toxin DMBA.

A deficiency of iodine is a known factor in the development of prostate cancer

1950's article links deficient thyroid activity with cancer rates

Data from 15 countries in four continents give support to the importance of local factors to account for the known local variations of cancer incidence - Iodine availability, traced by goiter incidence, appears to be one of such factors. Closer scrutiny of some of these countries corroborates these conclusions.

Presence of thyroxine in the tissues has been amply demonstrated in animal experiments to bring about a tissue environment that is unfavorable to tumor growth and development - at least as long as tumors remain in the dependent phase.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2007963/pdf/brjcancer00388-0003.pdf

Estrogen/Iodine Connection

Iodine metabolizes carcinogenic ESTRONE and estrogen metabolite 16-α-hydroxyestrone ==►  “anti-carcinogenic” estriol;

Iodine desensitizes estrogen receptors in the breast;

Iodine reduces estrogen production in overactive ovaries;

Mainstream medical treatments are not working

Breast cancer incidence worldwide has increased from 1 in 23 in the mid-1960s to currently 1 in 8, and is increasing by ~1% each year

Mortality rates not improved with today's technology surgery, chemotherapy, mammography, and radiation have not altered the mortality rate since record-keeping began in the 1920's. 85% of women who develop breast cancer will die of causes directly related to breast cancer.

Radiation and chemotherapy to the breast can affect the thyroid gland radiation to the breast for prevention of local recurrences can affect the thyroid gland. The thyroid gland in your neck is in close proximity to your breast and depending on the angle used by the radiation machine, the dosage used and also how good the machine is at preventing radiation scatter, the radiation can have both short and long term effect on your thyroid gland health. Chemotherapy (including Tamoxifen) delivers toxic compounds and can have side effects on many organs including the thyroid gland. The combination of chemotherapy and radiation can lead to clinically obvious low thyroid

Links JM, Radiation physics (ch16) and Williams ED, Biologic effects of radiation on the thyroid (ch17), Werner and Ingbar's The Thyroid, 1991.

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